کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921458 | 1559222 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Contrasting effects of estradiol and 17β-aminoestrogens on blood clotting time in rats and mice
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موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Contrasting effects of estradiol and 17β-aminoestrogens on blood clotting time in rats and mice Contrasting effects of estradiol and 17β-aminoestrogens on blood clotting time in rats and mice](/preview/png/9921458.png)
چکیده انگلیسی
Estrogens have been associated with thromboembolic events. Our group has described the anticoagulant effect of 17β-aminoestrogens in rodents, potentially new alternative estrogenic agents without thrombogenic risk. This work compares the contrasting effects of estradiol and the 17β-aminoestrogens (prolame, butolame, and pentolame) on blood clotting time. Ovariectomized CD1 mice received a single injection of 17β-aminoestrogens, estradiol (20 to 80 mg/kg), or vehicle. Estradiol decreased blood clotting time from â10% to â25% (48 h; P<0.01) and 17β-aminoestrogens increased it, differing in latency (â¼12 h; +48%, P<0.01) and duration (â¼72 h +58%, P<0.01). In male Wistar rats, similar effects (pentolame +45%; estradiol â31%; P<0.01) were observed 48 h after five consecutive daily injections of 1000 μg/animal/day. The maximum procoagulant effect of estradiol was obtained after 72 h with 10 μg/animal/day (â45%; P<0.01). 17β-Aminoestrogens always produced opposite effects to those of estradiol on blood coagulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 510, Issue 3, 14 March 2005, Pages 229-233
Journal: European Journal of Pharmacology - Volume 510, Issue 3, 14 March 2005, Pages 229-233
نویسندگان
Cristina Lemini, Yanira Franco, Ma. Estela Avila, Ruth Jaimez,