کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921507 | 1559225 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse Differentiation of opioid receptor preference by [Dmt1]endomorphin-2-mediated antinociception in the mouse](/preview/png/9921507.png)
چکیده انگلیسی
The potent opioid [Dmt1]endomorphin-2 (Dmt-Pro-Phe-Phe-NH2) differentiated between the opioid receptor subtypes responsible for the antinociception elicited by endomorphin-2 in mice. Antinociception, induced by the intracerebroventricular administration of [Dmt1]endomorphin-2 and inhibited by various opioid receptor antagonists [naloxone, naltrindole, β-funaltrexamine, naloxonazine], was determined by the tail-flick (spinal effect) and hot-plate (supraspinal effect) tests. The opioid receptor subtypes involved in [Dmt1]endomorphin-2-induced antinociception differed between these in vivo model paradigms: naloxone (non-specific opioid receptor antagonist) and β-funaltrexamine (irreversible μ1/μ2-opioid receptor antagonist) blocked antinociception in both tests, although stronger inhibition occurred in the hot-plate than the tail-flick test suggesting involvement of other opioid receptors. Consequently, we applied naloxonazine (μ1-opioid receptor antagonist) that significantly blocked the effect in the hot-plate test and naltrindole (δ-opioid receptor antagonist), which was only effective in the tail-flick test. The data indicated that [Dmt1]endomorphin-2-induced spinal antinociception was primarily mediated by both μ2- and δ-opioid receptors, while a supraspinal mechanism involved only μ1/μ2-subtypes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 509, Issue 1, 10 February 2005, Pages 37-42
Journal: European Journal of Pharmacology - Volume 509, Issue 1, 10 February 2005, Pages 37-42
نویسندگان
Yunden Jinsmaa, Yoshio Fujita, Kimitaka Shiotani, Anna Miyazaki, Tingyou Li, Yuko Tsuda, Yoshio Okada, Akihiro Ambo, Yusuke Sasaki, Sharon D. Bryant, Lawrence H. Lazarus,