کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921520 | 1559226 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Ethyl pyruvate protects PC12 cells from dopamine-induced apoptosis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
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چکیده انگلیسی
Pyruvate acid can protect cells against oxidative damage. However, its instability limits its usefulness as a therapeutic agent. In this study, we examined the effect of ethyl pyruvate, an aliphatic ester derived from pyruvate acid, on dopamine-induced cytotoxicity in rat pheochromocytoma PC12 cells. The results demonstrated that dopamine induced apoptosis in PC12 cells accompanied with increases of intercellular reactive oxygen species, nuclear translocation of nuclear transcription factor kappa B (NF-κB) and expression of p53 and decrease of mitochondrial transmembrane potential. Ethyl pyruvate markedly reduced the dopamine-induced production of reactive oxygen species, nuclear translocation of NF-κB, upregulation of p53, loss of mitochondrial transmembrane potential and apoptosis in PC12 cells. The results suggested that ethyl pyruvate might protect PC12 cells against dopamine by suppressing intercellular oxidative stress and modulating key signal pathways of apoptosis, and that ethyl pyruvate might be used as a potential therapeutic agent for Parkinson's disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 508, Issues 1â3, 31 January 2005, Pages 57-68
Journal: European Journal of Pharmacology - Volume 508, Issues 1â3, 31 January 2005, Pages 57-68
نویسندگان
Li-Zhen Wang, Wan-Chun Sun, Xing-Zu Zhu,