کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9921569 | 1559227 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Halothane sensitizes the canine heart to pharmacological IKr blockade
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Halothane sensitizes the canine heart to pharmacological IKr blockade Halothane sensitizes the canine heart to pharmacological IKr blockade](/preview/png/9921569.png)
چکیده انگلیسی
The effects of halothane and pentobarbital on the cardiovascular system were compared using the in vivo canine models. The ventricular repolarization process was longer under the halothane-anesthesia than pentobarbital-anesthesia. Intravenous administration of a selective blocker of rapidly activating delayed rectifier K+ currents (IKr) sematilide prolonged the ventricular repolarization period without affecting the intraventricular conduction under both anesthesia; however, the potency was about 1.5-folds greater under the halothane-anesthesia than pentobarbital-anesthesia. These results suggest that halothane can more effectively sensitize the heart to pharmacological IKr blockade, resulting in the excessive QT interval prolongation. Thus, the halothane-anesthetized canine model can be useful for predicting the in vivo IKr blocking property of new drugs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Pharmacology - Volume 507, Issues 1â3, 10 January 2005, Pages 169-177
Journal: European Journal of Pharmacology - Volume 507, Issues 1â3, 10 January 2005, Pages 169-177
نویسندگان
Akira Takahara, Atsushi Sugiyama, Yoshioki Satoh, Kai Wang, Sachiko Honsho, Keitaro Hashimoto,