کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9933615 | 1568468 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Quantitative analysis of the postnatal development of Purkinje neurons in the cerebellum of the cat
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کلمات کلیدی
PBSPCLEGLweek of gestationmGluR1αBSA - BSAbovine serum albumin - آلبومین سرم گاوIGL - ایگلphosphate buffer - بافر فسفاتPurkinje cell - سلول پورکنژ، یاخته پورکینیهNeuronal number - شماره عصبیinternal granular layer - لایه داخلی دانه ایPurkinje cell layer - لایه سلولی Purkinjeexternal granular layer - لایه گرانشی خارجیPhosphate-buffered saline - محلول نمک فسفات با خاصیت بافریCerebellum - مخچه
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have studied the postnatal quantitative changes of cortical Purkinje neurons in the cerebellum of the cat at the following postnatal groups of age: P0, P42, P72 and adults. An unbiased counting method, the optical fractionator was used for the estimation of Purkinje cell numbers. A significant increase of Purkinje cell number was found between P0 (1.097 Ã 106) and P42/P72 (1.805 Ã 106 and 1.895 Ã 106) declining to 1.429 Ã 106 in the adult, still 30% higher than in the newborn. It was also observed that during the first few postnatal weeks large “gaps” were present in the Purkinje monolayer as revealed by Nissl staining and metabotropic glutamate receptor 1α immunocytochemistry. These Purkinje cell gaps were observed most frequently in well-definable areas, especially in the intermediate zone of the neocerebellum. Simultaneously with the numerical increase of Purkinje neurons between the P0 and P72 age groups, these gaps disappeared after the third postnatal week resulting in the completion of the Purkinje monolayer in the whole cerebellum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 23, Issue 1, February 2005, Pages 27-35
Journal: International Journal of Developmental Neuroscience - Volume 23, Issue 1, February 2005, Pages 27-35
نویسندگان
Cs. Vastagh, J. VÃg, J. Takács, J. Hámori,