کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9952821 | 1469057 | 2018 | 42 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Scalable novel PVDF based nanocomposite foam for direct blood contact and cardiac patch applications
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موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Scalable novel PVDF based nanocomposite foam for direct blood contact and cardiac patch applications Scalable novel PVDF based nanocomposite foam for direct blood contact and cardiac patch applications](/preview/png/9952821.png)
چکیده انگلیسی
Scalable novel beta phase polyvinylidene fluoride-poly(methyl methacrylate) (PVDF-PMMA) polymer blend based nanocomposite foam with hydroxyapatite (HAp) and titanium dioxide (TiO2) as nanofillers (β-PVDF-PMMA/HAp/TiO2) (β-PPHT-f), was prepared by using salt etching assisted solution casting method. The prepared β-PPHT-f nanocomposite material was characterized using XRD, FT-IR, SEM-EDS. The XRD and FTIR results confirmed the formation of β phase of β-PPHT-f. The SEM and EDS results confirmed the formation of high porous structured closed cell type morphology of β-PPHT-f. It also, confirmed the uniform distribution of Ti, Ca, P, N and O, in β-PPHT-f. Contact angle measurements performed using sessile drop method with water and EDTA treated blood (EDTA blood) as probe liquids revealed that β-PPHT-f is hydrophilic with contact angle of 48.2° as well as hemophilic with contact angle of 13.7°. Porosity, fluid absorption and retention investigation by gravimetric analysis revealed that β-PPHT-f was 89.2% porous and can absorb and retain 139.15% and 87.05% of water and blood, respectively. The hemolysis assay performed as per ASTM F756 procedure revealed that β-PPHT-f is non hemolytic. Also, the Leishman stained blood smears prepared from whole blood incubated with β-PPHT-f for 3, 4, 5 and 6â¯h at 37â¯Â°C revealed that the blood cells were not affected by β-PPHT-f, its surface morphology and elemental composition. H9c2 cell line studies on a transparent film prepared using β-PPHT-f revealed that the elemental composition of the nanocomposite favored H9c2 cell adhesion and differentiation. All the characterization results indicate that the newly developed scalable novel β-PPHT-f is hemocompatible and cardiomyocyte compatible, suggesting it as a useful material for direct blood contact and cardiac patch applications.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 88, December 2018, Pages 270-280
Journal: Journal of the Mechanical Behavior of Biomedical Materials - Volume 88, December 2018, Pages 270-280
نویسندگان
Ratnakar Arumugam, Raj Kumar Chinnadurai, Bala Nehru Subramaniam, Bhuvaneshwar Devaraj, Veni Subramanium, Srinadhu Endu Sekhar, Satyanarayana Nallani,