Childhood adversity as a transdiagnostic risk factor for affective disorders in adulthood: A systematic review focusing on biopsychosocial moderating and mediating variables

- The relationship between childhood adversity and affective disorders seems to be moderated and mediated biopsychosocially
- More research is needed to clarify whether a given moderator/mediator acts disorder-specific or transdiagnostically
- Overall, the quality of studies in this line of research is moderate according to the proposed quality criteria
- It is recommended to include transdiagnostic and biopsychosocial conceptualizations in future research