کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9955414 | 1571123 | 2018 | 25 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice
ترجمه فارسی عنوان
تأثیر سیتیکولین بر فعالیت ضد افسردگی ناشی از سیتالوپرام در علائم افسردگی در موش های نر
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کلمات کلیدی
آزمون اجباری شنا آزمایش میدان باز، تست ترجیحی ساکارز، سیتیکولین، سیتالوپرام، همکاری اداری،
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
فیزیولوژی
چکیده انگلیسی
Depression is associated with significant functional disabilities. Application of new drugs which could enhance the effectiveness of antidepressants drug and reduce side effects of their long-term use seems necessary. Citicoline is used as an effective chemical agent for improving the symptoms of some neurodegenerative diseases. Therefore, in this survey, the application of citicoline as an adjuvant drug was evaluated in mice model of depression. A total of 180 adult NMRI male albino mice were used in this study. All groups were exposed to chronic unexpected mild stress (CUMS) followed by treatment with various doses of citalopram or/and citicoline or saline for 21â¯days. Sucrose preference (SP), open field (OF), and forced swimming test (FST) were applied to evaluate depression symptoms in the groups. The results indicated that only citicoline at the 5â¯mg/kg dose had shifted its status from being noneffective to become significantly effective in the co-administered group. The means of SP, OFT, and FST of the treatment groups were significantly different in favor of co-administered group compared with the other groups as well as the control group. Based on the results, it can be concluded that administration of citicoline, as an adjuvant drug, in combination with citalopram, enhanced the effectiveness of selective serotonin reuptake inhibitors (SSRI) drugs for depression treatment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Physiology & Behavior - Volume 195, 15 October 2018, Pages 151-157
Journal: Physiology & Behavior - Volume 195, 15 October 2018, Pages 151-157
نویسندگان
Mahtab Roohi-Azizi, Anahita Torkaman-Boutorabi, Shahin Akhondzadeh, Ali-Akbar Nejatisafa, Mitra-Sadat Sadat-Shirazi, Mohammad-Reza Zarrindast,