FK778 and Tacrolimus Prevent the Development of Obliterative Airway Disease After Heterotopic Rat Tracheal Transplantation

Although both agents proved effective to prevent OAD development, histology revealed major differences. The anti-proliferative potency of FK778 on SMC may be an important mechanism of action. Combination regimens showed favorable drug interaction and allowed dose reduction of both agents to achieve maximal immunosuppressive efficacy.