Prolonged Cold Ischemia in Rat Cardiac Allografts Promotes Ischemia-Reperfusion Injury and the Development of Graft Coronary Artery Disease in a Linear Fashion

These data indicate that the degree of cardiomyocyte apoptosis and inflammatory response in cardiac allografts during ischemia-reperfusion injury depends on the duration of cold ischemia. More important, that prolonged cold ischemia correlates with increased GCAD.