Post-Translational Modification of Manganese Superoxide Dismutase in Acutely Rejecting Cardiac Transplants: Role of Inducible Nitric Oxide Synthase

These results suggest that the decreased MnSOD enzyme activity in acutely rejecting cardiac allografts can be attributed to a post-translational modification related to nitration arising via an iNOS-dependent pathway. This could be a potential major source of amplified oxidative stress in acute graft rejection.