Long-term Therapy with the Acorn Cardiac Support Device Normalizes Gene Expression of Growth Factors and Gelatinases in Dogs with Heart Failure

This study shows that preventing left ventricular dilation and myocardial stretch with the CSD promotes normalization of growth factor and MMP gene expression. These results suggest that modulation of gene activity may, in part, contribute to the improvement of left ventricular function observed with CSD therapy.