Endothelin-1 Receptor Antagonist Prevents Deterioration of Left Ventricular Function and Coronary Flow Reserve in Brain-Dead Canine Heart

TAK-044 can prevent the deterioration of left ventricular function and coronary flow reserve that follows induction of brain death, suggesting that endothelin-1 could play an important role in hemodynamic deterioration by impairment of coronary microcirculation after brain death.