Non-Invasive Detection of Acute Allograft Rejection in Children by Tissue Doppler Imaging: Myocardial Velocities and Myocardial Acceleration During Isovolumic Contraction

Regional myocardial velocities change significantly during acute allograft rejection in children. However, many children already have wall motion abnormalities at baseline, so results are often difficult to interpret. In contrast, isovolumic acceleration was normal without rejection and selectively decreased during the event. IVA is a promising non-invasive rejection marker for pediatric patients.