کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9978991 1578718 2005 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mitral valve stiffening in end-stage heart failure: Evidence of an organic contribution to functional mitral regurgitation
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی کاردیولوژی و پزشکی قلب و عروق
پیش نمایش صفحه اول مقاله
Mitral valve stiffening in end-stage heart failure: Evidence of an organic contribution to functional mitral regurgitation
چکیده انگلیسی
Mitral valves in congestive heart failure have significantly altered mechanics that suggest that the tissue is permanently distended and fibrotic and might be unable to stretch sufficiently to cover the valve orifice. These material changes in the valve tissues accompany the biochemical alterations in extracellular matrix composition that we have previously reported. Our finding of leaflet and chordal remodeling suggests that mitral regurgitation in patients experiencing heart failure might not be purely functional and that these mitral valves should not be considered normal. Moreover, there are implications for strategies of mitral valve surgery or percutaneous approaches in this patient population.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The Journal of Thoracic and Cardiovascular Surgery - Volume 130, Issue 3, September 2005, Pages 783-790
نویسندگان
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