Keywords: 15-PGDH; Molecular dynamics simulation; Molecular docking; PGE2; MM-GBSA;
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Keywords: 15-PGDH; 15-hydoxyprostaglandin dehydrogenase; AA; arachidonic acid; AF; atrial fibrillation; AKI; acute kidney injury; Akt; alpha serine/threonine-protein kinase; ALA; alpha-linolenic acid; AMD; age-related macular degeneration; Ang II; angiotensin II; B
Keywords: Anti-diabetic; PPARγ; Gene expression; Molecular docking; Thiazolidinedione; Pyrazole; ALP; alkaline phosphatase; ALT; alanine transaminase; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase is an enzyme; AST; aspartate transaminase; DMEM; Dulb
Keywords: COX; cyclooxygenase; AA; arachidonic acid; HETE; hydroxyeicosatetraenoic acids; HPETE; hydroperoxyeicosatetraenoic acid; 15-PGDH; 15-prostaglandin dehydrogenase; oxo-ETE; oxo-eicosatetraenoic acid; PGE2; prostaglandin E2; EP; prostaglandin E receptor; FBS
Keywords: COX-2; 15-PGDH; HCC; Apoptosis; Tumor growth;
Targeting the 15-keto-PGE2-PTGR2 axis modulates systemic inflammation and survival in experimental sepsis
Keywords: 15k-PGE2; 15-keto-PGE2; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; ARE; anti-oxidant response element; BMDM; bone marrow-derived macrophages; CLP; cecum ligation/puncture; COX2; cyclooxygenase2; G6pd; glucose-6-phosphate dehydrogenase; HO-1; hemeoxyg
Prostaglandin E2 Activates YAP and a Positive-Signaling Loop to Promote Colon Regeneration After Colitis but Also Carcinogenesis in Mice
Keywords: Inflammation; Tumorigenesis; Villus Regeneration; Mouse Model; ANKRD1; ankyrin repeat domain 1; APC; adenomatous polyposis coli; ChIP; chromatin immunoprecipitation; COX-2; cyclooxygenase 2; CREB; cyclic adenosine monophosphate response element binding pr
Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells
Keywords: 15-PGDH; WNT-5A; JNK; β-Catenin; Colon cancer; rWNT-5a; recombinant WNT-5A; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; JNK; c-Jun N-terminal kinase;
Research reportChronic unpredictable mild stress induces parallel reductions of 15-PGDH in the hypothalamus and lungs in rats
Keywords: Stress; Anhedonia; Prostaglandin E2; 15-PGDH; Hypothalamus;
Genetics and Genetic Biomarkers in Sporadic Colorectal Cancer
Keywords: Genomic Instability; Microsatellite Instability; Chromosomal Instability; CIMP; ACF; aberrant crypt focus; CIMP; CpG island methylator phenotype; CIN; chromosomal instability; Cox-2; cyclo-oxygenase-2; CRC; colorectal cancer; EGFR; epithelial growth facto
Structure-activity relationship studies and biological characterization of human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase inhibitors
Keywords: HPGD; 15-PGDH; Prostaglandin; PGE2; Inhibitor;
Research ArticlemPGES-2 deletion remarkably enhances liver injury in streptozotocin-treated mice via induction of GLUT2
Keywords: mPGES-2; microsomal prostaglandin E synthase 2; STZ; streptozotocin; WT; wild type; KO; knockout; GLUT2; glucose transporter 2; GSH; glutathione; COX; cyclooxygenase; HO-1; haem oxygenase 1; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; SREBP-1c; sterol
15-PGDH/15-KETE plays a role in hypoxia-induced pulmonary vascular remodeling through ERK1/2-dependent PAR-2 pathway
Keywords: PH; pulmonary hypertension; PVR; pulmonary vascular remodeling; 15-HETE; 15-hydroxyeicosatetraenoic acid; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; 15-KETE; 15-ketoeicosatetraenoic acid; PAR-2; protease-activated receptor 2; PAs; pulmonary arteries;
The multi-faceted roles of prostaglandin E2 in cancer-infiltrating mononuclear phagocyte biology
Keywords: 13-PGR; Î13-15-ketoprostaglandin reductase; 15-PGDH; 15-prostaglandin dehydrogenase; APC; adenomatous polyposis coli; BM; bone marrow; cAMP; cyclic adenosine monophosphate; cDC; conventional DC; COX; cyclooxygenase; CTL; cytotoxic lymphocyte; DC; dendrit
Abnormal prostaglandin E2 production blocks myogenic differentiation in myotonic dystrophy
Keywords: DM; Myotonic dystrophy; DM1; Myotonic dystrophy type 1; cDM1; Congenital myotonic dystrophy type 1; DM2; Myotonic dystrophy type 2; DM1exp; DM1 cells carrying (CTG)n alleles where n > 3000; PGE2; Prostaglandin E2; PGF2; Prostaglandin F2; EP; E-prostanoi
MicroRNA-26a Promotes Cholangiocarcinoma Growth by Activating β-catenin
Keywords: Biliary Tract; Prostaglandin; COX-2; Post-Transcription Gene Regulation; COX-2; cyclooxygenase-2; CTD; C-terminal domain; GSK-3β; glycogen synthase kinase-3β; LEF; lymphoid enhancer factor; miRNA; microRNA; mRNA; messenger RNA; 15-PGDH; 15-hydroxyprosta
Regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) by non-steroidal anti-inflammatory drugs (NSAIDs)
Keywords: NSAIDs; 15-PGDH; MMPs; Protein expression; Protein turnover
Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH
Keywords: PG; prostaglandin; cPGES; cytosolic PGE synthase; 15-PGDH; 15-hydroxyprostaglandin dehydrogenase; mPGES; membrane-bound PGE synthase; COX; cyclooxygenase; PLA2; phospholipase A2; IL-1β; interleukin-1β; Prostaglandin E2; Cytosolic prostaglandin E synthas
Vitamin D and breast cancer: Inhibition of estrogen synthesis and signaling
Keywords: Calcitriol; Anti-proliferative effects; Breast cancer; Aromatase; Prostaglandins; 15-PGDH; COX-2; Aromatase inhibitors
Synthesis and SAR of thiazolidinedione derivatives as 15-PGDH inhibitors
Keywords: 15-PGDH, NAD+-dependent 15-hydroxyprostaglandin dehydrogenase; DTT, dithiothreitol; SDS, sodium dodecylsulfate; EDTA, ethylenediamine-N,N,N′,N′-tetraacetic acid; GST, glutathione S-transferase; THF, tetrahydrofuranThiazolidinediones; 15-PGDH; Ulcer healin
Molecular characterization of apocrine carcinoma of the breast: Validation of an apocrine protein signature in a well-defined cohort
Keywords: Breast cancer subtypes; Apocrine carcinoma; Protein signature; 15-PGDH; ACSM1; Patient stratificationIHC, Immunohistochemistry; 2-D PAGE, Two-dimensional polyacrylamide gel electrophoresis
Novel pathways that contribute to the anti-proliferative and chemopreventive activities of calcitriol in prostate cancer
Keywords: VDR; cDNA arrays; Target genes; IGFBP-3; Prostaglandins; 15-PGDH; COX-2; NSAIDs; MKP5; p38; IL-6; MIS
Differential expression and regulation of prostaglandin transporter and metabolic enzymes in mouse uterus during blastocyst implantation
Keywords: Embryo implantation; mouse; uterus; PGT; 15-PGDH; CBR1
Characterization of breast precancerous lesions and myoepithelial hyperplasia in sclerosing adenosis with apocrine metaplasia
Keywords: Breast precancerous lesions; Sclerosing adenosis; Apocrine carcinomas; Proteomics; 15-PGDH; CK15 positive myoepithelial and luminal cellsIHC, immunohistochemistry; 2D PAGE, two-dimensional polyacrylamide gel electrophoresis
IL-4 regulates COX-2 and PGE2 production in human non-small cell lung cancer
Keywords: NSCLC; IL-4; COX-2; PGE2; mPGES-1; 15-PGDH
Histone deacetylase inhibitors and transforming growth factor-β induce 15-hydroxyprostaglandin dehydrogenase expression in human lung adenocarcinoma cells
Keywords: 15-PGDH; COX-2; HDAC Inhibitors; TGF-β; Wnt; Tumor suppressor
15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line
Keywords: CAY 10397; 5-[[4-(ethoxycarbonyl)phenyl]azo]-2hydroxy-benzeneacetic acid; CHAPS; 3-[(3-cholamidopropyle) dimethyl ammonio]-1 propanesulfonate; COX; cyclooxygenase; DAPI; 4â²,6-diamidino-2-phenylindole; FCS; fetal calf serum; MTC; medullary thyroid carcin
Molecular mechanisms mediating the anti-proliferative effects of Vitamin D in prostate cancer
Keywords: CYP24; CYP27B1; VDR; cDNA arrays; Target genes; Prostaglandins; 15-PGDH; COX-2; NSAIDs;