Involvement of the constitutive prostaglandin E synthase cPGES/p23 in expression of an initial prostaglandin E2 inactivating enzyme, 15-PGDH

► The absence of cPGES/p23 results in decrease in expression of 15-PGDH. ► The absence of cPGES/p23 leads to accumulation of PGE2 in the culture supernatants. ► 15-PGDH gene expression is transcriptionally regulated by cPGES/p23. ► Introduction of 15-PGDH into cPGES/p23-null cells reverses extracellular PGE2 levels.