Keywords: Cholinesterase; 2-PAM; HI-6; Sarin; Nerve agent; Ellman assay;
مقالات ISI (ترجمه نشده)
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Keywords: 2-PAM; 2-pyridine aldoxime methylchloride; ACh; acetylcholine; AChE; acetylcholinesterase; Avp; arginine vasopressin; Bcat1; branched chain amino-acid transaminase; Btg2; B-cell translocation gene 2; Dbp; D site of albumin promoter binding protein; DEG; d
Oxime-assisted reactivation of tabun-inhibited acetylcholinesterase analysed by active site mutations
Keywords: Nerve agents; Cholinesterase; Antidotes; 2-PAM; HI-6; K-oximes;
Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model
Keywords: AChE; acetylcholinesterase; BBB; blood brain barrier; OP; organophosphorus agent; BChE; butyrylcholinesterase; 2-PAM; pralidoxime chloride; SNC; central nervous system; DHDAB; dihexadecyldimethylammonium bromide; DHDHAB; dihexadecylmethylhydroxyethylammon
An easy method for the determination of active concentrations of cholinesterase reactivators in blood samples: Application to the efficacy assessment of non quaternary reactivators compared to HI-6 and pralidoxime in VX-poisoned mice
Keywords: Organophosphorus-nerve agents; Oxime; Cholinesterase; Reactivation; Blood clearance; OPNA; organophosphorus-nerve agents; AChE; acetylcholinesterase; CNS; central nervous system; BBB; blood brain barrier; LD50; lethal dose 50%; 2-PAM; pralidoxime; MRT; Me
Conjugates of salicylaldoximes and peripheral site ligands: Novel efficient nonquaternary reactivators for nerve agent-inhibited acetylcholinesterase
Keywords: OP; organophosphate; hAChE; human acetylcholinesterase; ACh; acetylcholine; 2-PAM; pralidoxime; MINA; monoisonitrosoacetone; BBB; bloodbrain barrier; CNS; central nervous system; P-site; peripheral anionic site; PSL; peripheral site ligand; TIQ; tetrahydr
HI-6 assisted catalytic scavenging of VX by acetylcholinesterase choline binding site mutants
Keywords: Antidotes; Cholinesterase; Nerve agents; Organophosphates; Oximes; Reactivation; 2-PAM;
A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase
Keywords: ChE; cholinesterase; AChE; acetylcholinesterase; BChE; butyrylcholineserase; OP; organophosphate; CHO; Chinese Hamster Ovary; DMSO; dimethyl sulfoxide; 2-PAM; pralidoxime; ATC; acetylthiocholine iodide; BTC; butyrylthiocholine iodide; PDB; Protein Data Ba
Kinin-B2 receptor exerted neuroprotection after diisopropylfluorophosphate-induced neuronal damage
Keywords: 2-PAM; pralidoxime; AChE; acetylcholinesterase; ACSF; artificial cerebrospinal fluid; B1BKR; kinin-B1 receptor; B2BKR; kinin-B2 receptor; BK; bradykinin; DFP; diisopropylfluorophosphate; MEK/MAPK; mitogen-activated protein kinase; NMDA; N-methyl-d-asparta
In vitro reactivation of sarin-inhibited human acetylcholinesterase (AChE) by bis-pyridinium oximes connected by xylene linkers
Keywords: AChE, acetylcholinesterase; 2-PAM, 2-(hydroxyiminomethyl)-1-methylpyridinium chlorideBis-pyridinium oximes; Reactivators; 2-PAM; Organophosphorus nerve agents; Acetylcholinesterase; Obidoxime
Synthesis of some fluorine-containing pyridinealdoximes of potential use for the treatment of organophosphorus nerve-agent poisoning
Keywords: Fluoropyridines; Fluorinated pyridinecarboxaldehydes; Nerve agent; Oximes; 2-PAM; Sarin
Absence of tolerance to the anticonvulsant and neuroprotective effects of imidazenil against DFP-induced seizure and neuronal damage
Keywords: Imidazenil; Diazepam; Benzodiazepine; Organophosphates; Neuropathology; Seizure; Tolerance; GABA; γ-aminobutyric acid; DFP; diisopropyl fluorophosphate; OP; organophosphates; CWNA; chemical warfare nerve agent; AT; atropine sulfate; 2-PAM; pyridine-2-ald
Synthesis and in vitro evaluation of xylene linked carbamoyl bis-pyridinium monooximes as reactivators of organophosphorus (OP) inhibited electric eel acetylcholinesterase (AChE)
Keywords: Bis-pyridinium oximes; Reactivators; 2-PAM; Acetylcholinesterase; Xylene linkersAChE, Acetylcholinesterase; 2-PAM, 2-(hydroxyiminomethyl)-1-methylpyridinium chloride; DFP, diisopropyl flurophosphate
In vitro evaluation of bis-pyridinium oximes bearing methoxy alkane linker as reactivators of sarin inhibited human acetylcholinesterase
Keywords: AChE, Acetylcholinesterase; 2-PAM, Pralidoximechloride; TLC, Thin Layer ChromatographyAChE; Reactivators; Bis-pyridinium oximes; Nerve agents; 2-PAM; Obidoxime
New series of monoquaternary pyridinium oximes: Synthesis and reactivation potency for paraoxon-inhibited electric eel and recombinant human acetylcholinesterase
Keywords: Organophosphorus; Acetylcholinesterase; Reactivators; Monoquaternary pyridinium oximes; Pralidoxime; 2-PAM
Effects of oximes on mitochondrial oxidase activity
Keywords: 2-PAM; Oxime; Choline oxidase; Cytochrome c oxidase; Reactive oxygen species
In-vitro regeneration of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing xylene linker
Keywords: Bis-pyridinium oximes; Reactivators; 2-PAM; Organophosphorus nerve agents; Sarin; Acetylcholinesterase; Xylene linkers; AChE; acetylcholinesterase; 2-PAM; 2-(hydroxyiminomethyl)-1-methylpyridinium chloride;
Toxicity and characterization of cholinesterase-inhibition induced by diisopropyl fluorophosphate in Artemia salina larvae
Keywords: Diisopropyl fluorophosphate; Artemia salina; Atropine; Physostigmine; Pyridostigmine; 2-PAM
Synthesis and evaluation of novel bis-pyridinium oximes as reactivators of DFP-inhibited acetylcholinesterase
Keywords: Bis-pyridinium oximes; Reactivators; 2-PAM; Organophosphorus pesticides; Nerve agents; Acetylcholinesterase; DFP
Brain cholinesterase response in the snakehead fish (Channa striata) after field exposure to diazinon
Keywords: Channa striata; Cholinesterase; Biomarker Diazinon; 2-PAM
In vitro reactivation of sarin inhibited electric eel acetylcholinesterase by bis-pyridinium oximes bearing methoxy ether linkages
Keywords: AChE; acetylcholinesterase; GC; gas chromatography; IR; infrared spectroscopy; NMR; nuclear magnetic resonance spectroscopy; TLC; thin layer chromatography; VX; military code coined by British army; Bis-pyridinium oximes; Reactivators; 2-PAM; Sarin; Nerve
Characterization of asymmetric fluorogenic phosphonates as probes for developing organophosphorus hydrolases with broader stereoselectivity
Keywords: Flurogenic organophosphates; PON1; AChE; Oximes; 2-PAM; Toxogonin; Stereoselectivity
Computational study of the molecular complexes between cholesterol and two isomers of the pralidoxime (PAM)
Keywords: Cholesterol; 2-PAM; MP2; B3LYP; NBO;
Protective effect induced by atropine, carbamates, and 2-pyridine aldoxime methoiodide Artemia salina larvae exposed to fonofos and phosphamidon
Keywords: Atropine; Physostigmine; Pyridostigmine; 2-PAM; Acetylcolinesterase protection; Artemia; Fonofos; Phosphamidon
Hydrolysis of an acetylthiocholine by pralidoxime iodide (2-PAM)
Keywords: 2-PAM; AChE; ASCh; ACh; VX
Active site mutant acetylcholinesterase interactions with 2-PAM, HI-6, and DDVP
Keywords: Antidotes; Acetylcholinesterase; Butyrylcholinesterase; Reactivation; Reversible inhibition; 2-PAM; HI-6; Phosphorylation
Quaternary salts of 4,3′ and 4,4′ bis-pyridinium monooximes: Synthesis and biological activity
Keywords: Organophosphate; Pesticide; TEPP; Brain acetycholinesterase; 2-PAM; Bis-pyridinium monooximes; Reactivation