A step toward the reactivation of aged cholinesterases - Crystal structure of ligands binding to aged human butyrylcholinesterase

► Molecules designed to realkylate aged cholinesterases are proposed. ► Their X-ray structure in complex with aged butyrylcholinesterase was solved. ► The structures show an orientation of the molecules incompatible with realkylation. ► Better designs based on the X-ray structures are proposed.