کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2579767 1561583 2016 10 صفحه PDF سفارش دهید دانلود رایگان
عنوان انگلیسی مقاله ISI
Gastroprotective xanthones isolated from Garcinia achachairu: Study on mucosal defensive factors and H+, K+-ATPase activity
ترجمه فارسی عنوان
xanthones Gastroprotective جدا شده از achachairu عجیب: مطالعه عوامل دفاعی مخاط و فعالیت H +، K + -ATPase
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کلمات کلیدی
Xanthones؛ زخم معده؛ موسین؛ استرس اکسیداتیو؛ آنتی اکسیدانی، طیفی analysisAA، اسید اسکوربیک؛ CBX،
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Xanthones isolated from Garcinia achachairu display gastroprotective activity.
• Anti-ulcer effect is due the ability of increase protective factors of gastric mucosa.
• H+,K+-ATPase activity inhibition can explain xanthones anti-secretory effect.
• Efficacy of xanthones can contribute to improve the management of gastric diseases.

The present study was designed to investigate the gastroprotective effect of xanthones 7-preniljacareubin (PJB), 1,3,5,6-tetrahydroxy xanthone (THX), 3-demethyl-2-geranyl-4-prenylbellidypholine (DGP) and 1,5,8-trihydroxy-4′, 5′-dimethyl-2H-pyrane (2,3:3,2)-4-(3-methylbut-2-enyl) xanthone (TDP) isolated of branches from G. achachairu. Their structures were identified through the spectroscopic analysis in comparison with previously reported data. The xanthones were tested at dose of 10 mg/kg against ethanol 60%/HCl 0.3 N-induced gastric ulcer in female swiss mice. The xanthones PJB, THX, DGP and TDP exhibit gastroprotective effect after intraperitoneal treatment, but only the first two displayed anti-ulcer activity after oral administration. Both PJB and THX augmented the antioxidative capacity of tissue by an increase in glutathione levels, as well as were able to prevent an increase in myeloperoxidase activity and tumor necrosis factor level. On the other hand, only THX showed an in vitro free radical scavenger activity, and only PJB avoided mucus depletion on gastric mucosa, which was not associated with an increase in mucin production at glandular level. In addition, PJB and THX inhibited the in vitro H+K+-ATPase activity at similar range as omeprazole. Together, these results demonstrate the anti-ulcer efficacy of xanthones isolated from G. achachairu, which can contribute for future directions in the development of effective strategies to improve gastric diseases.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chemico-Biological Interactions - Volume 258, 25 October 2016, Pages 30–39
نویسندگان
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