Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants
Keywords: 1AP, 1-aminopyrene; 2AA, 2-aminoanthracene; ADMET, absorption, distribution, metabolism, excretion and toxicity; ADR, adverse drug reaction; CPR, cytochrome P450 oxidoreductase; δ-Ala, δ-aminolevulinic acid; DMEs, drug metabolizing enzymes; FI, Induction