کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9030723 | 1130940 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Genotoxicity studies on dietary diacylglycerol (DAG) oil
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کلمات کلیدی
2AA, 2-aminoanthracenePCE, polychromatic erythrocyteNCE, normochromatic erythrocyteB(a)P, benzo(a)pyrene - B (a) P، benzo (a) پیرنهCP, Cyclophosphamide - CP، سیکلوفسفامیدMMC, mitomycin C - MMC، میتومایسین CNaN3, sodium azide - NaN3، سدیم آیزیدTAG, triacylglycerol - TAG، تریآسیل گلیسرولdiacylglycerol - دیسیل گلیسیرینDAG, diacylglycerol - دیسیل گلیسیرینDMSO, dimethyl sulfoxide - دیمتیل سولفواکسیدDeep-frying - سرخ کردن عمیقGenotoxicity - سمیت ژنتیکیFat - چربی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم کشاورزی و بیولوژیک
دانش تغذیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Dietary diacylglycerol (DAG) oil is an edible oil enriched in DAG (more than 80%). A recent investigation indicated that DAG oil or its components may have beneficial effects on the prevention and management of obesity. We evaluated the genotoxic potential of DAG oil using standard genotoxicity tests. Bacterial reverse mutation assay (Ames test), the chromosomal aberration assay in cultured Chinese hamster lung cells (CHL/IU), and a bone marrow micronucleus assay in ICR CD mice were employed in the present study. In addition we have tested the possibility that genotoxic substances may be formed during cooking, heated DAG oil (HDG) was prepared by batch frying potato slices in the oil at 180 °C for 8 h/day for three consecutive days. Therefore, genotoxicity tests were also performed on HDG. Results obtained did not show any genotoxic effect on either unheated DAG oil (UDG) or HDG. We conclude that there are no safety concerns on the genotoxicity of DAG oil under the conditions for normal use.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food and Chemical Toxicology - Volume 43, Issue 2, February 2005, Pages 253-260
Journal: Food and Chemical Toxicology - Volume 43, Issue 2, February 2005, Pages 253-260
نویسندگان
T. Kasamatsu, R. Ogura, N. Ikeda, O. Morita, K. Saigo, H. Watabe, Y. Saito, H. Suzuki,