Keywords: Autophagy; Inflammatory bone loss; LPS; 4-PBA; Osteoclast;
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Keywords: 4-PBA; 4-phenylbutyric acid; ARA; arachidonic acid; ATF6; activating transcription factor 6; BiP or Grp78; 78-kDa glucose regulated protein; COX; cyclooxygenase; CYP; cytochrome P450; DHA; docosahexaenoic acid; eIF2α; eukaryotic translation initiation fa
Keywords: 4-Phenylbutyric acid; 4-PBA; UPR; ER stress
Keywords: 4-PBA; 4-phenylbutyrate; CC3; cleaved Caspase-3; CXCR4; chemokine (C-X-C motif) receptor 4; DMEM; Dulbecco's modified Eagle medium; EDTA; ethylenediaminetetraacetic acid; EM; electronic microscopic; ER; endoplasmic reticulum; FBS; fetal bovine serum; GR
Keywords: PFOA; perfluorooctanoic acid; ER stress; endoplasmic reticulum stress; 4-PBA; sodium 4-phenylbutyrate; ROS; reactive oxygen species; Cat; catalase; Sod1; superoxide dismutase 1; Sod2; superoxide dismutase 2; Sesn1; sestrin 1; LC3; microtubule-associated p
Keywords: 4-PBA; 4-phenylbutyric acid; CF; cardiac fibroblasts; ER; endoplasmic reticulum; FBS; fetal bovine serum; FCS; fetal calf serum; PBS; phosphate buffer saline; ROS; reactive oxygen species; UPR; unfolded protein response; Cardiac fibroblast; ER stress; Tha
Targeting the enhanced ER stress response in Marinesco-Sjögren syndrome
Keywords: Marinesco-Sjögren syndrome; ER stress; Lymphoblastoid cell line; Tunicamycin; Apoptosis; Tauroursodeoxycholic acid; 4-PBA; sodium phenylbutyrate; ATF6α; activating transcription factor 6α; CASP3; caspase-3; DEXA; dexamethasone; EBV; Epstein-Barr virus;
Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78
Keywords: 4-PBA; Aggregation; Degradation; GRP78; Protein secretion; Surfactant protein A2 mutations;
Aberrant endoplasmic reticulum stress mediates coronary artery spasm through regulating MLCK/MLC2 pathway
Keywords: ER; endoplasmic reticulum; CAS; coronary artery spasm; MLCK; myosin light chain kinase; MLC2; myosin II regulatory light chain; VSMCs; vascular smooth muscle cells; 4-PBA; 4-phenylacetic acid; Tm; tunicamycin; UPR; unfolded protein reaction; IRE1; inosito
Chemical chaperone 4-phenylbutylate reduces mutant protein accumulation in the endoplasmic reticulum of arginine vasopressin neurons in a mouse model for familial neurohypophysial diabetes insipidus
Keywords: FNDI; familial neurohypophysial diabetes insipidus; AVP; arginine vasopressin; ER; endoplasmic reticulum; 4-PBA; 4-phenylbutylate; SON; supraoptic nucleus; PVN; paraventricular nucleus; NPII; neurophysin II; ERAC; endoplasmic reticulum-associated compartm
Binge ethanol exposure induces endoplasmic reticulum stress in the brain of adult mice
Keywords: Alcohol use isorder; Brain damage; Endoplasmic reticulum tress; mTOR signaling; Neurodegeneration; Oxidative stress; ATF6; Activating transcription factor 6; IRE1α; Inositol-requiring kinase.; PERK; Protein kinase RNA-like endoplasmic reticulum kinase.;
Endoplasmic reticulum stress-dependent ROS production mediates synovial myofibroblastic differentiation in the immobilization-induced rat knee joint contracture model
Keywords: ATF6; activating transcription factor 6; ATF6α; activating transcription factor 6 alpha; CHOP; C/EBP homology protein; DMSO; dimethylsulphoxide; DCHF-DA; 2â²,7â²-dichlorofluorescein diacetate; DPI; diphenyleneiodonium; ER; endoplasmic reticulum; GAPDH;
Comparative hepatic transcriptome analyses revealed possible pathogenic mechanisms of fasiglifam (TAK-875)-induced acute liver injury in mice
Keywords: Fasiglifam (TAK-875); Drug-induced liver injury (DILI); Microarray; Comparative hepatic transcriptome analysis; Gene set enrichment analysis; ALT; Alanine aminotransferase; Bsep; Bile salt export pump; CCl4; Carbon tetrachloride; ConA; Concanavalin A; DAM
4-Phenyl butyric acid increases particulate hexokinase activity and protects against ROS injury in L6 myotubes
Keywords: 4-PBA; Hexokinase; L6 myotubes; Glucose uptake; GLUT4; Reactive oxygen species;
4-PBA reverses autophagic dysfunction and improves insulin sensitivity in adipose tissue of obese mice via Akt/mTOR signaling
Keywords: Akt/mTOR signaling; Autophagy; Insulin resistance; 4-PBA;
β-elemene regulates endoplasmic reticulum stress to induce the apoptosis of NSCLC cells through PERK/IRE1α/ATF6 pathway
Keywords: NSCLC; non-small-cell lung cancer; ER; endoplasmic reticulum; ERs; endoplasmic reticulum stress; 4-PBA; 4-phenylbutyric acid; WB; western blotting; q-PCR; quantitative reverse transcription polymerase chain reaction; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-
Original ArticleSensitivity towards the GRP78 inhibitor KP1339/IT-139 is characterized by apoptosis induction via caspase 8 upon disruption of ER homeostasis
Keywords: Sodium trans-[tetrachlorobis(1H-indazole)ruthenate(III)]; Ruthenium; Extrinsic pathway of programmed cell death; GRP78; Caspase 8; 4-PBA; 4-phenylbutyric acid; CHOP; C/EBP-homologous protein; CI; combination index; CFTR; cystic fibrosis transmembrane cond
The activation of autophagy protects neurons and astrocytes against bilirubin-induced cytotoxicity
Keywords: UCB; unconjugated bilirubin; TFP; trifluoroperazine; Bf; free bilirubin; 4-PBA; 4-phenyl-butyric acid; 4EBP; eukaryotic initiation factor 4E-binding protein; mTORC1; mammalian target of rapamycin complex 1; SQSTM1/p62; sequestosome-1 or ubiquitin-binding
Both nitric oxide and nitrite prevent homocysteine-induced endoplasmic reticulum stress and subsequent apoptosis via cGMP-dependent pathway in neuronal cells
Keywords: Nitric oxide; Nitrite; Endoplasmic reticulum stress; Apoptosis; cGMP; Neuronal cells; 7-AAD; 7-aminoactinomycin D; AD; Alzheimer's disease; ATF6; activating transcription factor 6; Br-cGMP; 8-bromo-cyclic cyclic guanosine 3â²,5â²-monophosphate; cGMP; cy
Ubiquitin-proteasome system and ER stress in the retina of diabetic rats
Keywords: Diabetic retinopathy; UCHL1; ERAD; Apoptosis; Autophagy; 4-PBA;
Functional Rescue of ABCC6 Deficiency by 4-Phenylbutyrate Therapy Reduces Dystrophic Calcification in Abcc6-/- Mice
Keywords: 4-PBA; 4-phenylbutyrate; DCC; dystrophic cardiac calcification; GACI; generalized arterial calcification of infancy; PPi; inorganic pyrophosphate; PXE; pseudoxanthoma elasticum;
Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response
Keywords: RFP; rifampicin; TUDCA; tauroursodeoxycholic acid; Nrf2; nuclear factor erythroid 2-related factor; DILI; drug-induced liver injury; ALF; acute liver failure; TB; tuberculosis; INH; isoniazid; GSH; glutathione; BAs; bile acids; ER; endoplasmic reticulum;
Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism
Keywords: AUDA; 12-[[(tricyclo[3.3.1.13,7]dec-1ylamino)carbonyl]amino]dodecanoic acid; 4-PBA; 4-phenylbutyric acid; GRP78; 78-kDa glucose-regulated protein; ATF6; Activating transcription factor 6; Ang-II; Angiotensin-II; CYP; Cytochrome P450; ER stress; Endoplasmi
Nox4 regulates the eNOS uncoupling process in aging endothelial cells
Keywords: eNOS; endothelial nitric oxide synthase; HUVEC; human umbilical vein endothelial cells; NO; nitric oxide; Nox4; NADPH oxidase 4; ROS; reactive oxygen species; NAC; N-acetyl cysteine; TUDCA; tauroursodeoxycholic acid; 4-PBA; 4-phenylbutyric acid; ER; endop
Targeted pharmacotherapies for defective ABC transporters
Keywords: 4-PBA; 4-phenylbutyrate; ABC; ATP-Binding Cassette; BRIC2; Benign Recurrent Intrahepatic Cholestasis type 2; BSEP; Bile Salt Export Pump; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane conductance Regulator; CsA; Cyclosporin A; DMSO; DiMethylSul
4-Phenylbutyric acid reduces mutant-TGFBIp levels and ER stress through activation of ERAD pathway in corneal fibroblasts of granular corneal dystrophy type 2
Keywords: ER stress; UPR; ERAD; 4-Phenylbutyric acid; TGFBIp; GCD2; Corneal fibroblasts; 4-PBA; Sodium 4-phenylbutyric acid; ATF6; Activating transcription factor 6; BiP; Binding immunoglobulin protein; CHOP; C/EBP homologous protein; ER; Endoplasmic reticulum; ERA
Research ArticleRescue of defective ATP8B1 trafficking by CFTR correctors as a therapeutic strategy for familial intrahepatic cholestasis
Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; 4-PBA; 4-phenyl butyric acid; SAHA; suberoylanilide hydroxamic acid; NB-DNJ; N-butyldeoxynojirimycin; BRIC; benign recurrent intrahepatic cholestasis; PFIC; progressive familial intrahepatic chole
Palmitic acid aggravates inflammation of pancreatic acinar cells by enhancing unfolded protein response induced CCAAT-enhancer-binding protein β-CCAAT-enhancer-binding protein α activation
Keywords: AP; acute pancreatitis; ATF6; activating transcription factor 6; BSA; bovine serum albumin; CCK-8; cholecystokinin-8; C/EBP; CCAAT-enhancer-binding protein; CHOP; CCAAT/enhancer binding protein (C/EBP) homologous protein; eIF2; αeukaryotic translation in
Palmitate-induced Endoplasmic Reticulum stress and subsequent C/EBPα Homologous Protein activation attenuates leptin and Insulin-like growth factor 1 expression in the brain
Keywords: 4-PBA; 4-phenyl butyric acid; 6-OHDA; 6-hydroxydopamine; Aβ; amyloid beta; AD; Alzheimer's disease; ATF3; activating transcription factor 3; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; BACE1; β-site APP cleaving enz
Single Amino Acid Deletion in Kindlin-1 Results in Partial Protein Degradation Which Can Be Rescued by Chaperone Treatment
Keywords: FA; focal adhesion; FERM; 4.1 protein, ezrin, radixin, moesin; F0-F3; FERM subdomains; FERMT1; kindlin-1 gene; KS; Kindler syndrome; K1; wild-type kindlin-1; K1R100del; mutant kindlin-1 p.R100del; KSKR100del; KS keratinocytes of patient 1 bearing the ho
Terpene glycoside component from Moutan Cortex ameliorates diabetic nephropathy by regulating endoplasmic reticulum stress-related inflammatory responses
Keywords: TCM; traditional Chinese Medicine; MC; Moutan Cortex; TG; terpene glycoside; DN; diabetic nephropathy; STZ; streptozotocin; AGEs; advanced glycation end-products; ER; endoplasmic reticulum; 4-PBA; 4-phenylbutyric acid; AG; amino guanidine; TEM; transmissi
9-Norbornyl-6-chloropurine (NCP) induces cell death through GSH depletion-associated ER stress and mitochondrial dysfunction
Keywords: NCP; 9-norbornyl-6-chloropurine; GST; glutathione-S-transferase; GSH; L-glutathione reduced; MMP; mitochondrial membrane potential; GR; glutathione reductase; PI; propidium iodide; 4-PBA; sodium phenylbutyrate; QUER; quercetin; ALLO; allopurinol; ABT; 1-a
Novel triterpenoid AECHL-1 induces apoptosis in breast cancer cells by perturbing the mitochondria-endoplasmic reticulum interactions and targeting diverse apoptotic pathways
Keywords: AECHL-1; Ailanthus excelsa chloroform extract-1; ER; Endoplasmic reticulum; PERK; Protein Kinase R-like ER kinase; eIF2α; eukaryotic Initiation Factor 2α; ROS; Reactive Oxygen Species; Nrf2; Nuclear factor (erythroid-derived 2)-like factor 2; GSH; Gluta
ER stress induced by the OCH1 mutation triggers changes in lipid homeostasis in Kluyveromyces lactis
Keywords: Fatty acids; Lipid droplets; 4-PBA; N-glycosylation; ER stress
Selective multifaceted E3 ubiquitin ligases barricade extreme defense: Potential therapeutic targets for neurodegeneration and ageing
Keywords: AAD; active adenylation domain; 4-PBA; 4-phenylbutyric acid; 6-OHDA; 6-hydroxydopamine; ABCG5/8; ATP-binding cassette sub-family G member 5/8; AD; Alzheimer's disease; AIB1; amplified in breast cancer 1; AIP4; atrophin-1 interacting protein 4; AMPA; α-
ER stress is associated with reduced ABCA-1 protein levels in macrophages treated with advanced glycated albumin - Reversal by a chemical chaperone
Keywords: ABCA-1; ATP binding cassette transporter class A type I; ABCG-1; ATPbinding cassette transporter class G type I; AGE; advanced glycation end products; AGE-alb; advanced glycated albumin; Apo A-I; apolipoprotein A-I; ATF6; activating transcription factor 6
Carbon monoxide, a reaction product of heme oxygenase-1, suppresses the expression of C-reactive protein by endoplasmic reticulum stress through modulation of the unfolded protein response
Keywords: ATF6; activating transcription factor 6; CRP; C-reactive protein; CO; carbon monoxide; CORM-2; CO-releasing molecule-2 (tricarbonyl dichlororuthenium dimer); CORM-3; CO-releasing molecule-3 (tricarbonylchliro(glycinate)ruthenium); CREBH; cyclic AMP respon
Cellular abnormalities linked to endoplasmic reticulum dysfunction in cerebrovascular disease-therapeutic potential
Keywords: Degenerative diseases; Endoplasmic reticulum; Ischemia; Stroke; Unfolded protein response; 4-PBA; 4-phenylbutyric acid; Aβ; amyloidogenic β-peptide; ATF; activating transcription factor; eIF2α; alpha subunit of the eukaryotic initiation factor 2; ER; e