Keywords: H2DCFDA; 2â²,7â²-dichlorofluorescein diacetate; 5-Aza-dC; 5-aza-2-deoxycytidine; CDCFDA; 5-(and-6)-carboxy-2â²,7â²-dichlorofluorescein diacetate; AdhSOD3; adenoviral vector containing human ECSOD cDNA; GFP; adenovirus containing green fluorescent prot
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Keywords: TME; tumour microenvironment; PD-1; programmed cell death 1; PD-L1; programmed death ligand 1; PD-L2; programmed death ligand 2; PTMs; post-translational histone modifications; DNMTi; DNA methyltransferase inhibitor; HDACi; histone deacetylase inhibitor;
Keywords: H. pylori; Helicobacter pylori; CGI; CpG islands; 5-Aza-dC; 5-aza-2â²-deoxycytidine; TSS; transcription start site; Epigenetics; Chromatin remodeling; DNA methylation; Field defect;
Keywords: HIF1/HIF-1; hypoxia inducible factor-1; VHL; von Hippel-Lindau; HRE; hypoxia response element; CBP; CREB binding protein; MBD; methyl-CpG binding domain; SRA; SET and RING finger-associated; KBS; Kaiso binding site; ANOVA; analysis of variance; FDR; fal
Keywords: ECMs; extracellular matrix; α-SMA; α-smooth muscle actin; TGF-β1; transforming growth factor-β1; Ang-II; angiotension II; DNMTs; DNA methyltransferases; 5-Aza-dC; 5-Aza-2â²-deoxycytidine; EZH2; Enhancer of zeste homolog 2; HDAC; histone deacetylases;
Reduced methylation downregulates CD39/ENTPD1 and ZDHHC14 to suppress trophoblast cell proliferation and invasion: Implications in preeclampsia
Keywords: DNA methylation; Preeclampsia; Trophoblast cells; 5-Aza-dC;
Hypericin inhibits hepatitis C virus replication via deacetylation and down-regulation of heme oxygenase-1
Keywords: Hepatitis C virus (HCV); Hypericin; Epigenetic; Deacetylation; HCV; Hepatitis C virus; NS5A; non-structure protein 5A; NS3; non-structure protein 3; HO-1; heme oxygenase 1; 5-Aza-dC; 5-aza-2â²-deoxycytidine; DAAs; direct acting antivirals; PCR; polymeras
Integrated data analysis identifies potential inducers and pathways during the endothelial differentiation of bone-marrow stromal cells by DNA methyltransferase inhibitor, 5-aza-2â²-deoxycytidine
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; ac-LDL; acetylated low-density lipoprotein; ANGPT; Angiopoietin; BMSCs; Bone-Marrow Stromal Cells; BSP; Bisulfite sequencing PCR; CD31/PECAM1; Platelet and endothelial cell adhesion molecule 1; CD105/ENG; Endoglin; eNOS
TRPM2 mediates mitochondria-dependent apoptosis of melanocytes under oxidative stress
Keywords: ROS; reactive oxygen species; MMP; mitochondrial membrane potential; TRPM2; transient receptor potential cation channel subfamily M member 2; H2O2; hydrogen peroxide; NHMs; Normal human melanocytes; NAC; N-acety-L-cysteine; Ru360; Ruthenium 360; 5-aza-dC;
NDRG2, suppressed expression associates with poor prognosis in pancreatic cancer, is hypermethylated in the second promoter in human gastrointestinal cancers
Keywords: NDRG2; Hypermethylation; Type II transcript; Gastrointestinal cancers; NDRG2; N-myc downstream regulated gene 2; 5-aza-dC; 5-Aza-2'deoxycytidine; TSA; Trichostatin A; qRT-PCR; quantitative reverse transcription polymerase chain reaction; cDNA; complementa
Cadmium-induced malignant transformation of rat liver cells: Potential key role and regulatory mechanism of altered apolipoprotein E expression in enhanced invasiveness
Keywords: IARC; International Agency for Research on Cancer; ApoE; Apolipoprotein E; LXR; liver X receptor; LXRE; liver X receptor response element; 5-aza-dC; 5-aza-2â²-deoxycytidine; ABCA1; ATP-binding cassette transporter; SREBP-1c; sterol regulatory element-bin
Inhibition of DNA Methylation in the COL1A2 Promoter by Anacardic Acid Prevents UV-Induced Decrease of Type I Procollagen Expression
Keywords: 5-AZA-dc; 5-AZA-2â²-deoxycytidine; AA; anacardic acid; bp; base pair; ChIP; chromatin immunoprecipitation; CPG; 5â²-cytosine-phosphate-guanine-3â²; DNMT; DNA methyltransferase; HAT; histone acetyltransferase; HDF; human dermal fibroblast; MMP; matrix m
Regulated expression of the TPβ isoform of the human T prostanoid receptor by the tumour suppressors FOXP1 and NKX3.1: Implications for the role of thromboxane in prostate cancer
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; AA; arachidonic acid; ADT; androgen deprivation therapy; AR; androgen receptor; BCR; biochemical recurrence; ChIP; chromatin immunoprecipitation; CNA; copy number alteration; COX; cyclooxygenase/prostaglandin G2/H2 synt
Frequent inactivation of MCC/CTNNBIP1 and overexpression of phospho-beta-cateninY654 are associated with breast carcinoma: Clinical and prognostic significance
Keywords: BC; breast carcinoma; ER; estrogen receptor; PR; progesterone receptor; TNBC; triple negative breast cancer; Her2; human epidermal growth factor receptor 2; UICC; International Union Against Cancer; TNM; tumor size, lymph node, metastasis; MA; microsatell
Increased expression of ApoE and protection from amyloid-beta toxicity in transmitochondrial cybrids with haplogroup K mtDNA
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; AD; Alzheimer's disease; AMD; Age-related Macular Degeneration; APOE; apolipoprotein E; ARPE-19; retinal pigmented epithelium cell line; ATP; adenosine triphosphate; BSA; bovine serum albumin; DMEM; Dulbecco's modified
High-glucose environment increased thrombospondin-1 expression in keratinocytes via DNA hypomethylation
Keywords: TSP1; thrombospondin-1; AGE; advanced glycation end-product; BSA; bovine serum albumin; 5-Aza-dC; 5-Aza-2'-deoxycytidine; MSP; methylation-specific PCR; ROS; reactive oxygen species; PBS; phosphate-buffered saline; PCR; polymerase chain reaction; Rluc; Re
EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82
Keywords: EGFR; epidermal growth factor receptor; LAC; lung adenocarcinoma; Del; deletion; WT; wild type; c-Cbl; casitas B-lineage lymphoma; GAK; cyclin G-associated kinase; NSCLC; non-small cell lung cancer; PKC; protein kinase C; SP-A; surfactant protein A; SP-C;
PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas
Keywords: HNSCC; Tumor suppressor gene; PHF21B; Epigenetic changes; Copy number alterations; 5-Aza-dC; 5-AZA-2â²-deoxicytidine; ENCODE; ENCyclopedia Of DNA Elements; HNSCC; head and neck squamous cell carcinoma; HPV; human papillomavirus; MS-HRM; Methylation Sensi
Genistein increases estrogen receptor beta expression in prostate cancer via reducing its promoter methylation
Keywords: 5-Aza-dC; 5-Aza-2â²-deoxycytidine; AR; androgen receptor; DMSO; dimethyl sulfoxide; DNMT; DNA methyltransferase; ER-β; estrogen receptor beta; FOXO-1; forkhead box O-1; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; MBD; methyl binding domain; MSP; me
Hypermethylation contributes to down-regulation of lysosomal β-hexosaminidase α subunit in prostate cancer cells
Keywords: Ceramide; Lysosomal glycohydrolases; Hexosaminidase A; Promoter methylation; BPH-1; hyperplasic prostate cell line; HexA; β-hexosaminidase A isoenzyme; HexB; β-hexosaminidase B isoenzyme; β-Hex; N-acetyl-β-d-hexosaminidase; MUβgala; 4 methylumbellife
Wnt inhibitory factor-1 functions as a tumor suppressor through modulating Wnt/β-catenin signaling in neuroblastoma
Keywords: WIF-1; Wnt inhibitory factor-1; MSP; methylation-specific PCR; 5-Aza-dC; 5-Aza-2â²-deoxycytidine; IHC; immunohistochemistry assay; IF; immunocytofluorescence assay; ICC; immunocytochemistry assay; Neuroblastoma; Wnt inhibitory factor-1 (WIF-1); Wnt/β-ca
Epigenetic Inactivation of KLF4 is Associated with Urothelial Cancer Progression and Early Recurrence
Keywords: urinary bladder; urothelium; carcinoma; genes; tumor suppressor; mortality; 5-AZA-dc; 5-aza-2-deoxycytidine; EMT; epithelial-to-mesenchymal transition; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; KLF4; Krüppel-like factor 4; NMIBC; nonmuscle invasiv
The methylation status of the platelet-derived growth factor-B gene promoter and its regulation of cellular proliferation following folate treatment in human glioma cells
Keywords: Glioma; PDGF-B; Gene methylation; Folate; 5-aza-dC
The role of DNA methylation in regulation of the murine Lhx3 gene
Keywords: 5-aza-dc; 5â²-aza-2â²-deoxycytidine; αGSU; alpha glycoprotein subunit; CpG; cytosine-phosphate bond-guanine; CPHD; combined pituitary hormone deficiency; DNMT; DNA methyltransferase; FSHβ; follicle-stimulating hormone; GnRH-R; gonadotropin-releasing h
Epigenetic genome-wide analysis identifies BEX1 as a candidate tumour suppressor gene in paediatric intracranial ependymoma
Keywords: Paediatric ependymoma; Pharmacological unmasking; 5-Aza-dC; DNA methylation; BEX1;
Re-expression and epigenetic modification of maspin induced apoptosis in MCF-7 cells mediated by myocardin
Keywords: DNMT; DNA methyltransferase; 5-aza-dc; 5-aza-2â²-deoxycytidine; HDAC; histone deacetylase; TSA; Trichostatin A; serpin; serine protease inhibitor; DMEM; Dulbecco's modified Eagle's medium; EB; ethidium bromide; PS; phosphatidylserine; TUNEL; terminal deo
DNA methylation: New therapeutic implications for hepatic fibrosis
Keywords: HSCs; hepatic stellate cells; ECMs; extracellular matrices; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; PDGF; platelet-derived growth factor; DNMTs; DNA methyltransferases; DNMT1; DNA methyltransferase 1; 5-Aza-dC; 5-Aza-2â²-de
Long-term cadmium exposure leads to the enhancement of lymphocyte proliferation via down-regulating p16 by DNA hypermethylation
Keywords: Cd; cadmium; LD; low dose; CFU-GM; colony forming unit-granulocyte and monocyte; WBC; while blood cells; 5-aza-dC; 5-aza-deoxycytidine; DNMT; DNA methyltransferase; MSP; methylation-specific PCR; Cadmium; Lymphoblast; Proliferation; p16; DNA methylation;
Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma
Keywords: 5-Aza-dC; 5-aza-2â²-deoxycytidine; ChIP; chromatin immunoprecipitation; Co-IP; co-immunoprecipitation; DNMT; DNA methyltransferase; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; MeCP2; methyl-CpG-binding protein 2; MIHA; immortalized non-tumo
Treatment of fetal fibroblasts with DNA methylation inhibitors and/or histone deacetylase inhibitors improves the development of porcine nuclear transfer-derived embryos
Keywords: Porcine nuclear transfer; Epigenetic modification; 5-aza-dC; TSA; Embryo development
DNA methyltransferases 1 and 3B are required for hepatitis C virus infection in cell culture
Keywords: Hepatitis C virus; Infection; Replication; DNMT1; DNMT3A; DNMT3B; 5-Aza-C; 5-Aza-dC
Amyloid protein-mediated differential DNA methylation status regulates gene expression in Alzheimer's disease model cell line
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; Aβ; beta amyloid; AD; Alzheimer's disease; APP; amyloid precursor protein; APP-sw; Swedish mutation of amyloid precursor protein; DMS; differentially methylated CpG site; MSP; methylation-specific PCR; qRT-PCR; quant
CpG methylation prevents YY1-mediated transcriptional activation of the vimentin promoter
Keywords: CpG methylation; Epigenetics; Intermediate filament; Transcriptional regulation; 5-aza-dC; 5-aza-2â²-deoxycytidine; ChIP; Chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IFP; int
Production of cloned calves by combination treatment of both donor cells and early cloned embryos with 5-aza-2/-deoxycytidine and trichostatin A
Keywords: Cloned calves; In vivo development; 5-aza-dC; Trichostatin A; Somatic cell nuclear transfer;
Aberrant up-regulation of LAMB3 and LAMC2 by promoter demethylation in gastric cancer
Keywords: 5-Aza-dC; 5-aza-2â²-deoxycytidine; ChIP; chromatin immunoprecipitation; mRNA; messenger RNA; qRT-PCR; quantitative reverse transcription-polymerase chain reaction; shRNA; short hairpin RNA; Demethylation; Malignant phenotype; Gastric carcinogenesis;
A glycobiology review: Carbohydrates, lectins and implications in cancer therapeutics
Keywords: Glycobiology review; Carbohydrates; Lectins; Cancer therapeutics; Cancer glycans; APC; antigen presenting cell; B4GALNT2; β-1,4-N-acetyl-galactosaminyltransferase; CDKL5; cyclin-dependent kinase-like 5; CNS; central nervous system; Con A; concanavalin A;
Analysis of expression and structure of the rat GH-secretagogue/ghrelin receptor (Ghsr) gene: Roles of epigenetic modifications in transcriptional regulation
Keywords: 5-aza-dC; 5-aza-2-deoxycytidine; ChIP; chromatin immunoprecipitation; ERK1/2; extracellular signal-regulated kinase 1/2; DMEM; Dulbecco's modified Eagle's medium; DNMT; DNA methyltransferase; EST; expressed sequence tag; FBS; fetal bovine serum; GH; g
Research ArticleEpigenetic inactivation of the tumor suppressor gene RIZ1 in hepatocellular carcinoma involves both DNA methylation and histone modifications
Keywords: HCC; hepatocellular carcinoma; LOH; loss of heterozygosity; TSG; tumor suppressor gene; RIZ1; retinoblastoma-interacting zinc finger; ChIP; chromatin immunoprecipitation; 5-Aza-dC; 5-aza-2-deoxycitidine; TSA; Trichostatin A; DNMT; DNA methyltransferase; H
Frequent Epigenetic Inactivation of Deleted in Lung and Esophageal Cancer 1 Gene by Promoter Methylation in Non–Small-Cell Lung Cancer
Keywords: 5-Aza-dC; Biomarker; DLEC1; Hypermethylation
The property of methylated APC gene promotor and its influence on lung cancer cell line
Keywords: APC; Epigenetic; 5-aza-dC; Methylation; Lung cancer
Distinct HIC1-SIRT1-p53 Loop Deregulation in Lung Squamous Carcinoma and Adenocarcinoma Patients
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; AD; adenocarcinoma; DBC1; deleted in breast cancer 1; H3K9me; histone H3 methylated at Lys9; H3K9ac; histone H3 acetylated at Lys9; HIC1; hypermethylation in cancer 1; MeCP2; methyl CpG binding protein 2; NSCLC; non-sma
Chemotherapeutic Drug-Induced ABCG2 Promoter Demethylation as a Novel Mechanism of Acquired Multidrug Resistance
Keywords: ABC; ATP-binding cassette; Act D; actinomycin D; ALL; acute lymphoblastic leukemia; COBRA; combined bisulfite restriction analysis; DNMT; DNA methyltransferase; DNR; daunorubicin; Dox; doxorubicin; FTC; fumitremorgin C; HDACi; histone deacetylase inhibito
ReviewRole of epigenetics in liver-specific gene transcription, hepatocyte differentiation and stem cell reprogrammation
Keywords: ADSC; adipose tissue-derived stem cells; ALB; albumin; AFP; alpha-fetoprotein; AhR; aryl hydrocarbon receptor; 5-AzaC; 5-Azacytidine or azacytidine; 5-Aza-dC; 5-Aza-2â²-deoxycytidine or decitabine; C/EBP; CCAAT/Enhancer Binding Protein; CYP; cytochrome P
Induction of MHC class I-related chain B (MICB) by 5-aza-2′-deoxycytidine
Keywords: 5-Aza-dC; DNA damage; DNA methyltransferase inhibitor; MICB
DNA Hypermethylation Contributes to Incomplete Synthesis of Carbohydrate Determinants in Gastrointestinal Cancer
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; COBRA; combined bisulfite restriction analysis; DNMT; DNA methyltransferase; EBV; Epstein-Barr virus; FUT; fucosyltransferase; Gal; galactose; GalNAc; N-acetylgalactosamine; GALNT; N-acetylgalactosaminyltransferase; GAP
Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter
Keywords: 5-aza-dC; 5-aza-2â²-deoxycytidine; BS; bisulfite sequencing; ChIP; chromatin immunoprecipitation; DNMT; DNA methyltransferase; GPx1; glutathione peroxidase 1; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; MAPK; mitogen-activated protein kinas
Epigenetic and functional analysis of IGFBP3 and IGFBPrP1 in cellular immortalization
Keywords: Immortalization; IGFBP3; IGFBP4; IGFBPrP1; DNA methylation; 5-aza-dC; CpG island; Epigenetic silencing; Interferon
A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns
Keywords: CpG; the DNA sequence “CG” where DNA methylation occurs; SINES; short interspersed transposable elements; LINES; long interspersed transposable elements; DNMT; DNA methyltransferase; siRNA; small interfering RNA; miRNA; Micro RNA; H; histone; HAT; his
p66shc is highly expressed in fibroblasts from centenarians
Keywords: Arg+; p53 codon 72 arginine allele homozygotes; 5-Aza-dC; 5-aza-2â²-deoxycytidine; DFO; deferoxamine; DFs; dermal fibroblasts; dRib2-deoxy-d-ribose; MEFs; mouse embryonic fibroblasts; PBMC; peripheral blood mononuclear cells; Pro+; p53 codon 72 proline a
Induction of clusterin/apoJ expression by histone deacetylase inhibitors in neural cells
Keywords: ApoE; apolipoprotein E; ApoJ; apolipoprotein J; 5-aza-dC; 5â²-aza-2â²-deoxycytidine; FBS; fetal bovine serum; CAPE; caffeic acid phenethyl ester; CLU; clusterin; EMSA; electrophoretic mobility shift assay; GRE; glucocorticoid/androgen response element;