Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HT4, 5-HT receptor type 4; HPA, hypothalamic–pituitary–adrenal; ACTH, adrenocorticotropic hormone, corticotropin; CRH, corticotropin-releasing hormone; MC, mast cells; SCF, stem cell factor; PPNAD, primary pigmented
مقالات ISI 5-HT، 5-hydroxytryptamine، serotonin (ترجمه نشده)
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Agomelatine affects rat suprachiasmatic nucleus neurons via melatonin and serotonin receptors
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; ACSF, artificial cerebrospinal fluid; cAMP, cyclic adenosine monophosphate; DMSO, dimethyl sulfoxide; PLC, phospholipase C; MT, melatonin; SCN, suprachiasmatic nucleusSuprachiasmatic nucleus; Melatonin; Agomelatine; 5
Contrasting regional Fos expression in adolescent and young adult rats following acute administration of the antidepressant paroxetine
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; ACTH, adrenocorticotropic hormone; AVP, arginine vasopressin; BNST, bed nucleus of the stria terminalis; CEA, central amygdala; CRF, corticotrophin-releasing factor; DR, dorsal raphe; ELISA, enzyme-linked immunosorben
ERK1/2: Function, signaling and implication in pain and pain-related anxio-depressive disorders
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; ACC, anterior cingulate cortex; AMY, amygdala; BBB, blood–brain barrier; BD, bladder distension; BDNF, brain-derived neurotrophic factor; CCAN, capsular central amygdaloid nucleus; CCI, chronic constriction injury; CD
Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; CNS, central nervous system; CORT, corticosterone; CSF, cerebrospinal fluid; CUMS, chronic unpredictable mild stress; FST, forced swim test; HPA, hypothalamic-pituitary adrenal; 5-HT, 5-hydroxytryptamine, serotonin; IDO, indoleamine-2,3-dioxygenase; IFN-γ
Neuropeptide S inhibits release of 5-HT and glycine in mouse amygdala and frontal/prefrontal cortex through activation of the neuropeptide S receptor
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; NPS, neuropeptide S; NPSRs, neuropeptide S receptors; SHA 68, 3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamideNeuropeptide S; 5-HT release; Glycine release; Amygdala; Frontal
Serotonin receptors involved in antidepressant effects
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; Antidepressant drugs; Major depression; Serotonin transporter; Serotonin receptors; SSRI; SNRI5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine, serotonin; BDNF, brain-derived neurotrophic factor; CREB, cyclic AMP response element-binding; CNS
Effect of delta-9-tetrahydrocannabinol on behavioral despair and on pre- and postsynaptic serotonergic transmission
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; CB1R, cannabinoid CB1 receptor; Delta-9-THC, (-)-trans-delta(9)-tetrahydrocannabinol; DR, dorsal raphe; FAAH, fatty acid amide hydrolase; MAGL, monoacylglycerol lipase; FST, forced swim test; OFT, open field test; WAY
An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; BALB/c; C57BL/6J; TPH; Serotonin; Tryptophan depletionBALB/c, BALB/cOlaH; C57BL/6J, C57BL6JOlaHsd; TPH, tryptophan hydroxylase; 5-HT, 5-hydroxytryptamine, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; FST, forced swim test; TST, tail suspension test; EPM
The genetics of selective serotonin reuptake inhibitors
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTT, 5-hydroxytryptamine transporter, serotonin transporter; 5-HTTLPR, 5-hydroxytryptamine transporter-linked polymorphic region; AC, adenylyl cyclase; ACTH, adrenocorticotropic hormone; AMPA, α-amino-3-hydroxy-5-me
Serotonin transporter deficiency protects mice from mechanical allodynia and heat hyperalgesia in vincristine neuropathy
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTT, serotonin transporter; ATF 3, activating transcription factor 3; CNS, central nervous system; DRG, dorsal root ganglia; HPLC, high performance liquid chromatography; ko, knock out; MAC1, mouse macrophages; PNS,
The effects of cocaine on light-induced activity
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; DA, dopamine; LIA, light-induced activity; NA, noradrenalinLight-induced activity; Cocaine; Locomotion; Rearing; Grooming
Evidence for in vivo thermosensitivity of serotonergic neurons in the rat dorsal raphe nucleus and raphe pallidus nucleus implicated in thermoregulatory cooling
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-CT, 5-carboxamidotryptamine; 5-HT, 5-hydroxytryptamine, serotonin; 8-OH-DPAT, (±)-8-hydroxy-dipropylaminotetraline; AH/POA, anterior hypothalamic area/preoptic area; ANOVA, analysis of variance; B4, B4 serotonergic cell group; CNS, central nervous syste
Serotonin transporter gene promoter polymorphism affects the severity of binge eating in general population
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTT, serotonin transporter; 5-HTTLPR, serotonin transporter linked polymorphic region; AN, anorexia nervosa; ANOVA, analysis of variance; AN-R, anorexia nervosa restrictive type; BED, binge eating diorder; BIS-11, B
Activation of serotonin 1A receptors in ventrolateral orbital cortex depresses persistent nociception: A presynaptic inhibition mechanism
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 8-OH-DPAT, 8-hydro-2-(di-n-propylamino) tetralin; ABC, avidin–biotin-peroxidase; ACSF, artificial cerebrospinal fluid; CNQX, 6-cyano-7-nitroquinoxaline-2,3-dione; DAB, 3,3-diaminobenzidine tetrahydrochloride; DL-AP5,
Subclinical effects of saxitoxin and domoic acid on aggressive behaviour and monoaminergic turnover in rainbow trout (Oncorhynchus mykiss)
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine, serotonin; AMPA, α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; ASP, amnesic shellfish poisoning; bw, body weight; Cg, granular layer of corpus cerebelli; Cm, molecular layer of corpus cere
Organic cation transporter inhibition increases medial hypothalamic serotonin under basal conditions and during mild restraint
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine, serotonin; aCSF, artificial cerebrospinal fluid; CNS, central nervous system; CORT, corticosterone; DA, dopamine; D-22, 1,11-diethyl-2,22-cyanine iodide, decynium 22; DMH, dorsomedial hypothal
5-HT3 receptors: Role in disease and target of drugs
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; BPAD, bipolar affective disorder; CB, cannabinoid; CINV, chemotherapy-induced nausea and vomiting; CNS, central nervous system; GABA, γ-aminobutyric acid; GERD, gastroesophagal reflux disease; GI, gastrointestinal; 5-HT, 5-hydroxytryptamine, serotonin; IB
Fast intra-axonal transport: Beginning, development and post-genome advances
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; CA, catecholamine(s); CFS, cytofluorimetric scanning; CNS, central nervous system; DA, dopamine; 5-HT, 5-hydroxytryptamine, serotonin; NA, noradrenaline; PNS, peripheral nervous system; NPY, neuropeptide Y; SP, substance P; TH, tyrosine hydroxylaseIntra-a
A genetic rat model of depression, Flinders sensitive line, has a lower density of 5-HT1A receptors, but a higher density of 5-HT1B receptors, compared to control rats
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 8-OH-DPAT, 8-hydroxy-2-(di-n-propylamino)tertraline; A, amygdala; Acb, nucleus accumbens; AM, posterior medial nucleus of amygdala; ANOVA, analysis of variance; AOM, medial anterior olfactory nucleus; Au, auditory cor
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; aCSF, artificial cerebrospinal fluid; AUC, area under the curve; CNS, central nervous system; HPLC, high-pressure liquid chromatography; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTP, 5-hydroxy-l-tryptophan; LD50, lethal dose at 50% death rate; LD100, letha
Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTTLPR, serotonin transporter-linked polymorphic region; AFR, animal facility rearing; ANOVA, analysis of variance; CLi, caudal linear nucleus of the raphe; DR, dorsal raphe nucleus; DRD, dorsal raphe nucleus, dorsa
Ethnic differences in the serotonin transporter polymorphism (5-HTTLPR) in several European populations
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTT, serotonin transporter, 5-HTTLPR, serotonin transporter gene-linked polymorphic region; 5-HTT or SLC6A4, 5-HTT gene; L, long allele; NS, non-significant; PCR, polymerase chain reaction; S, short alleleBashkirs;
Serotonergic approaches in the development of novel antipsychotics
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; Schizophrenia; Serotonin; 5-HT1A; 5-HT2C; 5-HT6; 5-HT7; SSRI; Antipsychotic; D28-OH-DPAT, 8-hydroxy-2-(di-N-propylamino)-tetralin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HTP, 5-hydroxytryptophan; ACh, acetylcholine; CAR, conditioned avoidance response; D
Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HIAA, 5-hydroxyindoleacetic acid, serotonin metabolite; AP, anterior–posterior; EDTA, ethylenediaminetetraacetic acid; CV, coefficient of variation; DMSO, dimethylsulfoxide; ECF, extracellular fluid; i.p., intraperi
Animal models of human psychopathology based on individual differences in novelty-seeking and anxiety
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; BrdU, 5-bromo-2′-deoxyuridine; 5-HIAA, 5-hydroxyindole acetic acid; 5-HT, 5-hydroxytryptamine, serotonin; 8-OH-DPAT, 8-hydroxy-2-di-N-propylaminotetralin; ACTH, adrenocorticotropic hormone; AHA, Australian high avoidance; ALA, Australian low avoidance; AP
Caveolin-1 affects serotonin binding and cell surface levels of human 5-HT7(a) receptors
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-MeOT, 5-metoxytryptamine; GPCR, G protein coupled receptor; Cav-1, caveolin-1; siRNA, small interfering RNA; KD, dissociation constant; MβCD, methyl-β-cyclodextrinCaveolae; Lipid rafts; Receptor trafficking; GPCR; 5
A unique role for striatal serotonergic systems in the withdrawal from adolescent nicotine administration
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HIAA, 5-hydroxyindoleacetic acid; 5-HT, 5-hydroxytryptamine, serotonin; ANOVA, analysis of variance; DA, dopamine; PN, postnatal; SSRIs, serotonin-specific reuptake inhibitors.Adolescence; Dopamine; Nicotine withdrawal; Serotonin; Striatum
Pharmacokinetic–pharmacodynamic modeling of the effect of fluvoxamine on p-chloroamphetamine-induced behavior
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; Bmax, maximal SERT occupancy; CL, systemic clearance; DMSO, dimethylsulfoxide; EC50, fluvoxamine plasma concentration at half of the maximal inhibitory effects of fluvoxamine on PCA-induced behavior; ECF, extracellula
Exogenous Serotonin Regulates Proliferation of Interstitial Cells of Cajal in Mouse Jejunum Through 5-HT2B Receptors
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; ICC, interstitial cells of Cajal; PCR, polymerase chain reaction; RT, reverse transcriptase; RT-qPCR, real-time quantitative PCR
Retrograde labeling reveals extensive distribution of genioglossal motoneurons possessing 5-HT2A receptors throughout the hypoglossal nucleus of adult dogs
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; IV, 4th ventricle; XII, Hypoglossal nucleus; 5-HT, 5-hydroxytryptamine, serotonin; 5-HT2AR, Serotonin receptor subtype 2A; CTB, Cholera toxin B subunit; Cy2, Cyanine dye 2; d, depth; DAB, Diaminobenzidine; (DAB-Ni)-H2O2, Diaminobenzidine-nickel peroxidase
Differentiating antidepressants of the future: Efficacy and safety
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; ACh, acetylcholine; AD, Alzheimer's Disease; AV, atrio-ventricular; BDNF, brain derived neurotrophic factor; CCI, chronic constriction injury; CeA, central amygdala; CPPC, chronic painful physical conditions; CRF, cor
No effect of prolonged corticosterone over-exposure on NCAM, SGK1, and RGS4 mRNA expression in rat hippocampus
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; Kir, inwardly rectifying potassium channel; NCAM, neural cell adhesion molecule; RGS4, regulator of G-protein signaling 4; SGK1, serum- and glucocorticoid-regulated kinase 1Corticosterone; Hippocampus; Rat; Neural cel
Somato-dendritic distribution of 5-HT1A and 5-HT1B autoreceptors in the BDNF- and cAMP-differentiated RN46A serotoninergic raphe cell line
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; BDNF, brain-derived neurotrophic factor; dBcAMP, N6-2′-O-dibutyryladenosine 3′:5′-cyclic monophosphate; R5-HT1A, type 1A serotonin receptor; R5-HT1B, type 1B serotonin receptorSerotoninergic neuronal phenotype; RN46A;
Role of the conserved NPxxY motif of the 5-HT2A receptor in determining selective interaction with isoforms of ADP-Ribosylation Factor (ARF)
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; 5-HT, 5-hydroxytryptamine, serotonin; 5-HT2AR, 5-hydroxytryptamine 2A receptor; i2, second intracellular loop domain; i3, third intracellular loop domain; TM7, 7th transmembrane domain; CT, carboxy-terminal tail domain; GPCR, G protein-coupled receptor; A
The four-plates test: Anxiolytic or analgesic paradigm?
Keywords: 5-HT، 5-hydroxytryptamine، serotonin; AD(s), antidepressant(s); BZD(s), benzodiazepine(s); FPT, four-plate test; GABA, gamma-aminobutyric acid; 5-HT, 5-hydroxytryptamine, serotonin; NA, noradrenaline; PAG, periaqueductal gray; SSRI(s), selective serotonin reuptake inhibitor(s); SNRI, serotoni