کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4312809 | 1612990 | 2013 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation Swimming exercise ameliorates depression-like behavior in chronically stressed rats: Relevant to proinflammatory cytokines and IDO activation](/preview/png/4312809.png)
Chronic stress is involved in development of depression and causes immune alterations. Indoleamine-2,3-dioxygenase (IDO) plays a pivotal role in mediating the depression-like behaviors in response to immune activation. Physical exercise has been shown to reduce the stress impairment and ameliorate depressive symptoms. The objectives of present study were to confirm that chronic unpredictable mild stress (CUMS) induces depression-like behavior and inflammatory responses within the brain, and then investigate whether swimming exercise alleviates the depression-like behaviors induced by CUMS through proinflammatory cytokine-induced alteration of IDO in brain. It has been found that CUMS exposure induced depression-like behavior, increased serum corticosterone (CORT) level, decreased 5-HT level, increased IFN-γ and TNF-α levels and elevated IDO activity in prefrontal cortex. Moreover, the level of 5-HT was inversely correlated with IDO level. Regular swimming exercise ameliorated depressive symptoms induced by CUMS. The exercise reduced serum CORT level, increased 5-HT level as well as decreased levels of IFN-γ, TNF-α and IDO in prefrontal cortex in CUMS rats. These findings suggested that CUMS activate HPA axis and induce immune activation, which may stimulate IDO activity, leading to the reduction of 5-HT level in brain, thereby resulting in depression. Swimming exercise may inhibit activation of inflammation/IDO pathways induced by CUMS, thereby ameliorating depression.
► CUMS increased serum corticosterone level.
► CUMS induced depression-like behavior in rats.
► CUMS elevated IFN-γ, TNF-α and IDO levels in prefrontal cortex.
► Swim ameliorated depression-like behavior induced by CUMS.
► Swim decreased IFN-γ, TNF-α and IDO levels in prefrontal cortex in CUMS rats.
Journal: Behavioural Brain Research - Volume 242, 1 April 2013, Pages 110–116