Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; cys-LTs, cysteinyl-leukotrienes; DMEM, Dulbecco's modified Eagle's medium; EIA, enzyme immunoassay; ERK, extracellular signal-regulated kinases; LTs, leukotrienes; MAPKs, mitogen-activated protein kinases; MPO,
مقالات ISI 5-LO، 5-lipoxygenase (ترجمه نشده)
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Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; BBB, blood–brain barrier; EB, Evan's blue; fEPSP, field excitatory post-synaptic potential; FLAP, 5-lipoxygenase activating protein; FPI, fluid percussion injury; Gd, gadolinium-diethylenetriamine pentaacetic acid; LTP, long-term pot
Analgesic potential of standardized methanol stem bark extract of Ficus platyphylla in mice: Mechanisms of action
Keywords: 5-LO، 5-lipoxygenase; AI, Analgesic Index; COX, Cyclooxygenase; FP, Ficus Platyphylla; HEK, Human Embryonic Kidney; HTP, Hot Plate Nociceptive Threshold; 5-LO, 5-Lipoxygenase; DOR, δ Opiod Receptor; KOR, κ Opioid Receptor; MOR, µ Opioid Receptor; sal, Saline; TPT, Hot-Plate Th
The hallucinogenic diterpene salvinorin A inhibits leukotriene synthesis in experimental models of inflammation
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; cys-LTs, cysteinyl-leukotrienes; DMSO, dimethyl sulfoxide; EIA, enzyme immunoassay; H&E, hematoxylin and eosin; HPLC, high-performance liquid chromatography; IL-10, interleukin 10; LPS, lipopolysaccharide; LT, l
5-Lipoxygenase inhibitors suppress RANKL-induced osteoclast formation via NFATc1 expression
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; LTs, leukotrienes; BMMs, bone marrow-derived macrophages; BMMCs, bone marrow-derived mast cells; LPS, lipopolysaccharide; M-CSF, macrophage-colony stimulating factor; RANK, a receptor of RANKL; RANKL, receptor activator of nuclear fa
Secretory Phospholipases A2 Are Secreted From Ciliated Cells and Increase Mucin and Eicosanoid Secretion From Goblet Cells
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; ALI, air-liquid interface; BALF, BAL fluid; cysLT, cysteinyl leukotriene; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HBE, human bronchial epithelial; LO, lipoxygenase; LTB4, leukotriene B4; LTC4, leukotriene C4; mRNA, messenger
Human cytomegalovirus infection induces leukotriene B4 and 5-lipoxygenase expression in human placentae and umbilical vein endothelial cells
Keywords: 5-LO، 5-lipoxygenase; Placenta; Human cytomegalovirus; Histoculture; 5-Lipoxygenase; Endothelial cells; LTB45-HETE, 5-hydroxyeicosatetraenoic acid; 5-LO, 5-lipoxygenase; HCMV, human cytomegalovirus; HUVECs, human umbilical vein endothelial cells; LTs, leukotrienes; LTB4, leuko
Leukotriene receptor antagonist as a novel tocolytic in an in vitro model of human uterine contractility
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; 12-LO, 12-lipooxygenase; AA, arachidonic acid; CysLTR1, cysteinyl leukotrienes receptor 1; COX, cyclooxygenase; CYP450, cytochrome P450; DAG, diacylglycerol; EETs, epoxy-eicosatrienoic acid regioisomers; IP3, inositol 1,4,5-triphosph
An experimental cell-based model for studying the cell biology and molecular pharmacology of 5-lipoxygenase-activating protein in leukotriene biosynthesis
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; 5-H(p)ETE, 5-hydro(pero)xy-6-trans 8,11,14-cis-eicosatetraenoic acid; 12-LO, 12-lipoxygenase; AA, arachidonic acid; cPLA2, cytosolic phospholipase A2; FLAP, 5-lipoxygenase-activating protein; HEK cells, human embryonic kidney cells;
Monitoring tissue inflammation and responses to drug treatments in early stages of mice bone fracture using 50 MHz ultrasound
Keywords: 5-LO، 5-lipoxygenase; 3D, three-dimensional; 5-LO, 5-lipoxygenase; AA, arachidonic acid; Asp, aspirin; BLT1, Leukotriene B4 receptor 1; COX, cyclooxygenase; COX-2, cyclooxygenase-2; DAB, 3,3′-Diaminobenzidine; ddH2O, double distilled H2O; EtOH, ethanol; FBS, fetal bovine serum
Exhaled breath condensate: Determination of non-volatile compounds and their potential for clinical diagnosis and monitoring. A review
Keywords: 5-LO، 5-lipoxygenase; 3-NT, 3-nitrotyrosine; 5-HPETE, 5-hydroperoxyeicosatetraenoic acid; 5-LO, 5-lipoxygenase; 8-IP, 8-isoprostane; ALF, airway lining fluid; BAL, bronchoalveolar lavage; CF, cystic fibrosis; COPD, chronic obstructive pulmonary disease; COX, cyclooxygenase; EB
Inhibition of 5-lipoxygenase by U73122 is due to covalent binding to cysteine 416
Keywords: 5-LO، 5-lipoxygenase; AA, arachidonic acid; 5-LO, 5-lipoxygenase; 12-LO, 12-lipoxygenase; 15-LO, 15-lipoxygenase; CAM, carbamidomethylation; CHCA, α-cyano-4-hydroxycinnamic acid; LTA4, leukotriene A4; NEM, N-ethylmaleinimide; PBS, phosphate-buffered saline; PB, phosphate buffe
New approaches to personalized medicine for asthma: Where are we?
Keywords: 5-LO، 5-lipoxygenase; Personalized medicine; asthma; genomics; pharmacogenomics; drug treatment; whole genome sequencingED, Emergency department; 5-LO, 5-Lipoxygenase; GWAS, Genome-wide association study; ICS, Inhaled corticosteroid; LABA, Long-acting β2-agonist; NAEPP, Nation
Emodin, a naturally occurring anthraquinone derivative, suppresses IgE-mediated anaphylactic reaction and mast cell activation
Keywords: 5-LO، 5-lipoxygenase; BMMC, bone marrow-derived mast cell; Syk, spleen tyrosine kinase; LAT, linker of activated T cells; PLCγ1, phospholipase Cγ1; cPLA2α, cytosolic phospholpase A2α; COX-2, cyclooxygenase-2; 5-LO, 5-lipoxygenase; PCA, passive cutaneous anaphylaxisEmodin; Pass
Reactive oxygen species in cardiovascular disease
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; 5-MTHF, 5-methyltetrahydrofolate; 12-LO, 12-lipoxygenase; 12/15-LO, 12/15-lipoxygenase; ACS, acute coronary syndrome; ApoA-I, apolipoprotein A-I; ApoE, apolipoprotein E; BH4, 5,6,7,8-tetrahydrobiopterin; CAD, coronary artery disease;
The activity of medicinal plants and secondary metabolites on eosinophilic inflammation
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; BALF, bronchoalveolar lavage fluid; CD, cluster of differentiation; Cys-LTs, cysteinyl leukotrienes; ECP, eosinophil cationic protein; EDN, eosinophil-derived neurotoxin; EGID, eosinophilic gastrointestinal diseases; EPO, eosinophil
Attenuated Th1 induction by dendritic cells from mice deficient in the leukotriene B4 receptor 1
Keywords: 5-LO، 5-lipoxygenase; Lipid mediator; Knockout mouse; Inflammation; Hypersensitivity; Arachidonic cascadeBLT, leukotriene B4 receptor; DTH, delayed-type hypersensitivity; GPCR, G-protein coupled receptor; LT, leukotriene; LTB4, leukotriene B4; 5-LO, 5-lipoxygenase; rmIL-12, re
Associations of genetic polymorphisms of arachidonate 5-lipoxygenase-activating protein with risk of coronary artery disease in a European–American population
Keywords: 5-LO، 5-lipoxygenase; AA, arachidonic acid; ALOX5AP, arachidonate 5-lipoxygenase-activating protein; CAD, coronary artery disease; EPA, eicosapenetenoic acid; 5-LO, 5-lipoxygenase; LTA4, leukotriene A4; LTC4, leukotriene C4; MI, myocardial infarctionALOX5AP; FLAP; Genetics; Co
4-Hydroxynonenal enhances CD36 expression on murine macrophages via p38 MAPK-mediated activation of 5-lipoxygenase
Keywords: 5-LO، 5-lipoxygenase; HNE, 4-hydroxynonenal; 5-LO, 5-lipoxygenase; oxLDL, oxidized low-density lipoprotein; LTB4, leukotriene B4; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; DiI, 1,1′-dioctadecyl-3,3,3′3′-tetramethylindocarbocyanine perc
5-Lipoxygenase plays a role in the control of parasite burden and contributes to oxidative damage of erythrocytes in murine Chagas’ disease
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; NDGA, nordihydroguaiaretic acid; TBH, tert-butyl hydroperoxide; NO, nitric oxide; TNF-α, tumor necrosis factor alpha; ROS, reactive oxygen species; LTs, leukotrienes; LTA4, leukotriene A4; LTB4, leukotriene B4; LTA4H, leukotriene A4
New pyridone, thioxopyridine, pyrazolopyridine and pyridine derivatives that modulate inflammatory mediators in stimulated RAW 264.7 murine macrophage
Keywords: 5-LO، 5-lipoxygenase; Pyridine; Pyridone; Thioxopyridine; Pyrazolopyridine; Anti-inflammatory; Cycloxygenase-2; 5-LipoxygenaseCOX-2, cycloxygenase-2; FITC, fluorescein isothiocyanate; 5-LO, 5-lipoxygenase; LPS, bacterial lipopolysaccharide; NO, nitric oxide; O2−, superoxide ra
Leukocyte lipid bodies — Biogenesis and functions in inflammation
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; ACAT, acyl-coenzyme A:cholesterol acyltransferase; ADRP, adipose differentiation related protein; BCG, Bacillus Calmett Guerrin; COX, cyclooxygenase; cPLA2, cytosolic phospholipase A2; EDAC, 1-ethyl-3 (3-dimethy
Vitamin E: The shrew waiting to be tamed
Keywords: 5-LO، 5-lipoxygenase; AVED, α-tocopherol deficiency; CEHC, carboxyethyl hydroxychroman; COX-2, cyclooxygenase-2; DAG, diacylglycerol; DGK, DAG kinase; L, lipid radical; 5-LO, 5-lipoxygenase; LOO, lipid peroxyl radical; 8-oxodG, 8-oxo-7,8-dihydroguanine; PA, phosphatidic acid;
Oxidative risk for atherothrombotic cardiovascular disease
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; Ab, antibodies; ABC, ATP-binding cassette; apoA-1, apolipoprotein A-1; apoB-100, apolipoprotein B-100; apoE, apolipoprotein E; BH2,, dihydrobiopterin; BH4, 5,6,7,8-tetrahydrobiopterin; BR, biliverdin reductase;
Corticosteroids as inhibitors of cysteinyl leukotriene metabolic and signaling pathways
Keywords: 5-LO، 5-lipoxygenase; Cysteinyl leukotrienes; corticosteroids; IL-4CCS, Corticosteroid; CysLT, Cysteinyl leukotriene; CysLT1R, Cysteinyl leukotriene receptor 1; CysLT2R, Cysteinyl leukotriene receptor 2; 5-LO, 5-Lipoxygenase; LT, Leukotriene; LTC4S, Leukotriene C4 synthase
The development of methodology for clinical measurement of 5-lipoxygenase pathway intermediates from human peripheral blood mononuclear cells
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; 5-HETE, 5-hydroxyeicosatetraenoic acid; 5-HPETE, 5-hydroperoxyeicosatetraeinoic acid; AA, arachidonic acid; cPLA2, cytosolic phospholipase A2; CPT, cell preparation tubes; CV, coefficient of variation; CysLTs, cysteinyl leukotrienes;
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; COX, cyclooxygenase; fMLP, n-formyl-Methionyl-Leucyl-Phenylalanine; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GM-CSF, granulocyte-macrophage colony-stimulating factor; HBSS, Hank's balanced salt solution;
Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress
Keywords: 5-LO، 5-lipoxygenase; 5-HEDH, 5-hydroxyeicosanoid dehydrogenase; 5-HETE, 5S-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5-LO, 5-lipoxygenase; 5-oxo-ETE, 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid; 5R-HETE, 5R-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid; 12-HEDH, 12-hydroxyeico
Sodium nitroprusside decreased leukotriene C4 generation by inhibiting leukotriene C4 synthase expression and activity in hepatic ischemia-reperfusion injured rats
Keywords: 5-LO، 5-lipoxygenase; SNP, sodium nitroprusside; NO, nitric oxide; eNOS, constitutively expressed endothelial NO synthase; iNOS, inducible NO synthase; I/R, ischemia and reperfusion; LT, leukotriene; 5-LO, 5-lipoxygenase; LTC4S, leukotriene C4 synthase; mGST, microsomal glutat
CD8+ T lymphocytes and leukotriene B4: Novel interactions in the persistence and progression of asthma
Keywords: 5-LO، 5-lipoxygenase; CD8; T cells; leukotriene B4; IL-13; asthmaAHR, Airway hyperresponsiveness; BAL, Bronchoalveolar lavage; BLT1, Receptor for leukotriene B4; 5-LO, 5-Lipoxygenase; LTB4, Leukotriene B4; TCM, Central memory CD8+ T cells; TEFF, Effector memory CD8+ T cells
Differential production of leukotriene B4 or prostaglandin E2 by WKYMVm or serum amyloid A via formyl peptide receptor-like 1
Keywords: 5-LO، 5-lipoxygenase; AA, arachidonic acid; LTB4, leukotriene B4; PGE2, prostaglandin E2; GPCR, G-protein coupled receptor; PLA2, phospholipase A2; cPLA2, cytosolic PLA2; iPLA2, calcium independent PLA2; sPLA2, secretory PLA2; 5-LO, 5-lipoxygenase; COX, cyclooxygenase; FPRL1,,
Therapeutic options for 5-lipoxygenase inhibitors
Keywords: 5-LO، 5-lipoxygenase; 5-LO, 5-lipoxygenase; AA, arachidonic acid; COX, cyclooxygenase; cPLA2, cytosolic phospholipase A2; CVD, cardiovascular disease; ERK, extracellular signal-regulated kinase; FLAP, 5-lipoxygenase-activating protein; fMLP, N-formyl-methionyl-leucyl-phenylala
Adenosine 5′-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation
Keywords: 5-LO، 5-lipoxygenase; 2-MeS-ATP, 2-methylthio-ATP; 5-LO, 5-lipoxygenase; AA, arachidonic acid; ABC, ATP-binding cassette; ADA, adenosine deaminase; Ado, adenosine; ADPβS, adenosine 5′-O-(2-thiodiphosphate); AP-1, activator protein-1; ATL-146e, 4-{3-[6-amino-9-(5-ethylcarbamoyl