کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3203767 | 1202016 | 2006 | 6 صفحه PDF | دانلود رایگان |
The contribution of CD8+ T cells to the development of airway hyperresponsiveness and airway inflammation has received increased attention recently. CD8+ T cells, which are capable of secreting TH2 cytokines, including IL-4, IL-5, and IL-13, have been described in asthmatic subjects and in animals sensitized and challenged with allergen. A subset of these IL-13–producing CD8+ T cells, effector memory CD8+ T cells in the mouse, express a high-affinity receptor for leukotriene B4 (BLT1), and expression of this receptor is essential for their accumulation in the lung and development of airway hyperresponsiveness and airway inflammation. A similar subset of CD8+/BLT1+/IL-13+ T cells has also been identified in the bronchoalveolar lavage fluid of asthmatic subjects, suggesting a pathogenic role for this unique subset of CD8+ T cells in asthma.
Journal: Journal of Allergy and Clinical Immunology - Volume 117, Issue 3, March 2006, Pages 577–582