Dual inhibition of 5-LOX and COX-2 suppresses esophageal squamous cell carcinoma
Keywords: ESCC; COX-2; 5-LOX; Nude mice;
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Inhibition of 5-lipoxygenase triggers apoptosis in prostate cancer cells via down-regulation of protein kinase C-epsilon
Keywords: 5-LOX; 5-Lipoxygenase; 5-oxoETE; 5-oxoeicosatetraenoic acid; PKCε; Protein Kinase C-epsilon; PARP; poly-ADP ribose polymerase; ELISA; enzyme-linked immunosorbent assay; 5-Lipoxygenase; Prostate cancer; Apoptosis; PKC-epsilon;
Pharmacophore modeling and virtual screening for designing potential 5-Lipoxygenase inhibitors
Keywords: 5-LOX; Asthma; Pharmacophore modeling; Docking; Virtual screening; Lipoxygenase inhibitor
5-Lipoxygenase in mouse cerebellar Purkinje cells
Keywords: 5-Lipoxygenase; cerebellum; Purkinje cell; Dicer; DNA methylation; FLAP; CaBP-28; calbindin 28-kDa protein; DEPC; diethylpyrocarbonate; DIG; digoxigenin; FLAP; 5-lipoxygenase activating protein; LCM; laser capture microdissection; LTB4; leukotriene B4; M-
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors
Keywords: UJVFAMUGBPTESE-DHZHZOJOSA-NPrenylated chalcone; 5-LOX; Docking; LUDI; Claisen–Schmidt condensation reaction; Anti-proliferative
Activation of 5-lipoxygenase is required for nicotine mediated epithelial–mesenchymal transition and tumor cell growth
Keywords: 5-LOX; EMT; Nicotine; Gastric cancer; E-cadherin; Snail
A Mutant of Hepatitis B Virus X Protein (HBxÎ127) Promotes Cell Growth through A Positive Feedback Loop Involving 5-Lipoxygenase and Fatty Acid Synthase
Keywords: 5-LOX; 5-lipoxygenase; COX; cyclooxygenase; FAS; fatty acid synthase; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; Indo; indomethacin; LTB4; leukotriene B4; p-ERK1/2; phosphorylated extracellular signal-regulated protein kinases 1/2; S
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans
Keywords: Lauraceae; Neolignans; Bicyclo[3.2.1]octane; Benzofuran; COX; 5-LOX; Platelet aggregation;
The anti-inflammatory pharmacology of Pycnogenol® in humans involves COX-2 and 5-LOX mRNA expression in leukocytes
Keywords: Flavonoids; 5-LOX; COX-2; Gene expression
A novel ex vivo skin model for the assessment of the potential transcutaneous anti-inflammatory effect of topically applied Harpagophytum procumbens extract
Keywords: Skin; Transcutaneous delivery; Inflammation; Devil's Claw; H. procumbens; COX-2; PGE-2; 5-LOX; iNOS
Increased urinary leukotriene E4 excretion in obstructive sleep apnea: Effects of obesity and hypoxia
Keywords: Leukotriene E4; obstructive sleep apnea syndrome; nocturnal oxygen desaturation; obesity; AHI; Apnea-hypopnea index; BMI; Body mass index; CPAP; Continuous positive air pressure; CRP; C-reactive protein; cysLT; Cysteinyl leukotriene; 11-DehydroTXB2; 11-De
Diaryl-dithiolanes and -isothiazoles: COX-1/COX-2 and 5-LOX-inhibitory, OH scavenging and anti-adhesive activities
Keywords: COX-1/2; 5-LOX; Dual inhibitors; Hydroxyl radical scavenging; Anti-adhesive activities; Leukocyte–endothelial interactions
An in vitro screening cascade to identify neuroprotective antioxidants in ALS
Keywords: 5-LOX; 5-lipoxygenase; AAPH; 2,2â²-azobis(2-methylpropionamidine) dihydrochloride; ALS; amyotrophic lateral sclerosis; ARE; antioxidant response element; BBB; blood-brain barrier; CAPE; caffeic acid phenethyl ester; CNS; central nervous system; DCF; di
5-LOX, 12-LOX and 15-LOX in immature forms of human leukemic blasts
Keywords: Lipoxygenase; 5-LOX; 12-LOX; 15-LOX; Human leukemic blasts; LTB4; 12-HETE; 15-HETE
Investigations concerning the COX/5-LOX inhibiting and hydroxyl radical scavenging potencies of novel 4,5-diaryl isoselenazoles
Keywords: COX-1/2; 5-LOX; Dual inhibitors; Hydroxyl radical scavenging; Isoselenazoles
In vitro 5-lipoxygenase inhibition and anti-oxidant activity of Eriocephalus L. (Asteraceae) species
Keywords: 5-LOX; 5-lipoxygenase enzyme; DMSO; dimethylsulfoxide; DPPH; 2,2-diphenyl-1-picrylhydrazyl; NDGA; nordihydroguaiaretic acid; SANBI; South African National Biodiversity Institute; NBRI; National Botanical Research Institute; DPP; Department of Pharmacy and
Synthesis, stereochemical assignments, and biological activities of homoisoflavonoids
Keywords: Homoisoflavonoids; Synthesis; Stereochemical assignments; Antioxidant activity; 5-LOX
Molecular modeling of the non-covalent binding of the dietary tomato carotenoids lycopene and lycophyll, and selected oxidative metabolites with 5-lipoxygenase
Keywords: 5-HETE; 5-oxo-EET; 5-Lipoxygenase; 5-LOX; Astaxanthin; Blind docking; Homology modeling; Lycopene; Lycophyll; Oxidative metabolites
Essential structural profile of a dual functional inhibitor against cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX): Molecular docking and 3D-QSAR analyses on DHDMBF analogues
Keywords: COX-2; 5-LOX; Dual inhibitor; NSAIDs; DHDMBF; Homology modeling; Docking; 3D-QSAR; CoMFA; CoMSIA
Increased expression of cysteinyl leukotriene receptor-1 in the brain mediates neuronal damage and astrogliosis after focal cerebral ischemia in rats
Keywords: cysteinyl leukotriene receptor; cerebral ischemia; neuronal damage; astrogliosis; pranlukast; cysteinyl leukotriene receptor antagonist; ANOVA; analysis of variance; CysLTs; cysteinyl leukotrienes; CysLT1 receptor; cysteinyl leukotriene receptor-1; ECA; e
A mechanistic study of colon cancer growth promoted by cigarette smoke extract
Keywords: 5-LOX; Colon cancer; Cigarette smoke; Angiogenesis; MMP; VEGF1;
Urinary leukotriene E4 excretion is increased in type 1 diabetic patients
Keywords: ACE inhibitor; angiotensin converting enzyme inhibitor; GMC; diabetic patients with good metabolic control; LC-MS/MS; liquid chromatography-tandem mass spectrometry; 5-LOX; 5-lipoxygenase; LTE4; leukotriene E4; PMC; diabetic patients with poor metabol