Keywords: ABCB1; ATP-binding cassette subfamily B member 1; ABCC2; ATP-binding cassette subfamily C member 2; CDS; clinical decision support; CPIC; clinical pharmacogenetics implementation consortium; CYP; cytochrome P450; MDR 1; multidrug resistance 1 gene; EHR; e
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Keywords: neonatal cholestasis; ABCC2; MRP2; black liver; molecular genetic analysis; ABCC2; ATP-binding cassette sub-family C member 2; BSEP; Bile salt export pump; D Bil; Direct bilirubin; GGT; γ-glutamyltransferase; MRP2; Multidrug resistance-associated protein
Keywords: HHC; Human Hepatocellular Carcinoma; LCSLC; sliver cancer stem-like cells; TRPV2; Transient Receptor Potential Vanilloid-type 2 channel; TRP; Transient Receptor Potential; SCID; severe combined immunodeficiency; ALDH1; aldehyde dehydrogenase 1; GFP; green
Keywords: 5-FU; 5-Fluorouracil; ABCB5; ATP-binding cassette sub-family B member 5; ABCC2; ATP-binding cassette sub-family C member 2; ABCG2; ATP-binding cassette sub-family G member 2; ACs; Anthocyanins; ALDH; aldehyde dehydrogenase; AML; acute myeloid leukemia; AP
Association of Allelic Interaction of Single Nucleotide Polymorphisms of Influx and Efflux Transporters Genes With Nonhematologic Adverse Events of Docetaxel in Breast Cancer Patients
Keywords: ABCB1; ABCC2; Pharmacogenetics; SLCO1B3; SNPs;
Cellular Pharmacokinetic Model-Based Analysis of Genistein, Glyceollin, and MK-571 Effects on 5 (and 6)-Carboxy-2â²,7â²-Dichloroflourescein Disposition in Caco-2 Cells
Keywords: active transport; Caco-2 cells; drug transport; efflux pumps; intestinal secretion/transport; membrane transport; pharmacokinetics; transcellular transport; transporters; ABCC2; ATP binding cassette sub-family C, member 2; ABCC3; ATP binding cassette sub-
Farmacogenética de reacciones adversas a fármacos antiepilépticos
Keywords: Farmacogenética; Reacciones adversas a medicamentos; Fármacos antiepilépticos; CYP2C9; ABCC2; AntÃgeno leucocitario humano (HLA); Pharmacogenetics; Adverse drug reactions; Antiepileptic drugs; CYP2C9; ABCC2; Human leukocyte antigen (HLA);
Effects of UGT2B7, SCN1A and CYP3A4 on the therapeutic response of sodium valproate treatment in children with generalized seizures
Keywords: VPA; sodium valproate; FABP2; fatty acid binding protein 2; ABCB1; ATP binding cassette subfamily B member 1; ABCC2; ATP binding cassette subfamily C member 2; GABA; gamma-aminobutyric acid; ABAT; 4-aminobutyrate aminotransferase; GABR; GABA receptor; SCN
Digital gene-expression profiling analysis of the fatty liver of Landes geese fed different supplemental oils
Keywords: ABCA1; ATP-binding cassette, sub-family A, member 1; ABCB4; ATP-binding cassette, sub-family B, member 4; ABCC2; ATP-binding cassette, sub-family C, member 2; ABCG5; ATP-binding cassette, sub-family G, member 5; ABCG8; ATP-binding cassette, sub-family G,
Identification of Bacillus thuringiensis Cry1AbMod binding-proteins from Spodoptera frugiperda
Keywords: ABCC2; ATP binding cassette subfamily C member 2; ALP; alkaline phosphatase; APN; aminopeptidase-N; BBMV; brush border membrane vesicles; Bt; Bacillus thuringiensis; CNBr; Cyanogen bromide; GPI; glycophosphatidylinositol; kDa; Kilodalton; LC-MS/MS; liqu
The ABCC2 c.-24CÂ >Â T polymorphism increases the risk of resistance to antiepileptic drugs: A meta-analysis
Keywords: ABCC2; Epilepsy; Antiepileptic drugs; Polymorphism; Meta-analysis;
A structure-activity relationship study of ABCC2 inhibitors
Keywords: ABC; ATP binding cassette; ABCC2; ATP binding cassette protein subfamily C member 2; CDCF; 5(6)-Carboxy-2â²,7â²-dichlorofluorescein; SAR; Structure-activity relationship; Transporter; MRP2; Modulator; Vesicle assay; Pharmacophore;
The domain II loops of Bacillus thuringiensis Cry1Aa form an overlapping interaction site for two Bombyx mori larvae functional receptors, ABC transporter C2 and cadherin-like receptor
Keywords: ABC; ATP-binding cassette; ABCC2; ABC transporter subfamily C2; BtR175-TBR; toxin binding region of Bombyx mori cadherin-like receptor; APN; Amino peptidase N; SPR; Surface plasmon resonance; Bacillus thuringiensis; Cry toxin; Receptor interaction site; A
Single nucleotide polymorphisms of ABCC2 modulate renal secretion of endogenous organic anions
Keywords: Multidrug resistance-associated protein 2; Endogenous substrates; ABCC2; Single nucleotide polymorphisms; Metabolomics;
Effects of ABCB1, ABCC2, UGT2B7 and HNF4α genetic polymorphisms on oxcarbazepine concentrations and therapeutic efficacy in patients with epilepsy
Keywords: Oxcarbazepine; Pharmacogenetics; ABCB1; ABCC2; UGT2B7; HNF4α;
Deletion of liver-specific STAT5 gene alters the expression of bile acid metabolism genes and reduces liver damage in lithogenic diet-fed mice
Keywords: STAT5; signal transducer and activator of transcription 5; GH; growth hormone; IGF-1; insulin-like growth factor-1; LDLR; low-density lipoprotein receptor; STAT5 LKO; liver-specific STAT5 knock-out; STAT5 fl/fl; STAT5 flox/flox; TG; triacylglycerol; ChMCs
Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy
Keywords: Lamotrigine; Pharmacogenetics; OCT1; ABCG2; ABCC2; HNF4α;
Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study
Keywords: ABC; ATP-binding cassette; ABCB1; ATP-Binding Cassette Sub-Family B (MDR/TAP) Member 1; ABCC1; ATP-Binding Cassette Sub-Family C (CFTR/MRP) Member 1; ABCC2; ATP-Binding Cassette Sub-Family C (CFTR/MRP) Member 2; BSID-II; Bayley scales of infant developmen
Osteomalacia induced by long-term low-dose adefovir dipivoxil: Clinical characteristics and genetic predictors
Keywords: Adefovir dipivoxil; Hypophosphatemic osteomalacia; Clinical characteristic; SLC22A6; ABCC2; Risk genotype;
Single amino acid insertions in extracellular loop 2 of Bombyx mori ABCC2 disrupt its receptor function for Bacillus thuringiensis Cry1Ab and Cry1Ac but not Cry1Aa toxins
Keywords: Bt; Bacillus thuringiensis; ABCC2; ABC transporter C2; BtR175; cadherin-like receptor in Bombyx mori; BBMV; brush border membrane vesicles; Bacillus thuringiensis; ABC transporter C2; BmABCC2; Receptor; Cry1A; Domain II; Bombyx mori;
Nanoencapsulated curcumin and praziquantel treatment reduces periductal fibrosis and attenuates bile canalicular abnormalities in Opisthorchis viverrini-infected hamsters
Keywords: OV; Opisthorchis viverrini; CCA; cholangiocarcinoma; NEC; nanoencapsulated curcumin; PZQ; praziquantel; PDF; periductal fibrosis; BC; bile canaliculi; Cur; curcumin; ALT; alanine transaminase; MMP; matrix metalloproteinases; TIMP; tissue inhibitors of MMP
Homologs to Cry toxin receptor genes in a de novo transcriptome and their altered expression in resistant Spodoptera litura larvae
Keywords: Spodoptera litura; Bacillus thuringiensis; Transcriptome; Cry1Ca receptor; Resistance; Bt; Bacillus thuringiensis; APN; aminopeptidase-N; GPI; glycosylphosphatidyl-inositol; ALP; alkaline phosphatase; ABCC2; ATP-binding cassette transporter subfamily C2;
Agonist of farnesoid X receptor protects against bile acid induced damage and oxidative stress in mouse placenta - A study on maternal cholestasis model
Keywords: Farnesoid X receptor; Intrahepatic cholestasis of pregnancy; Oxidative stress; Placenta; Farnesoid X receptor agonist; WAY-362450; Abcb11; ATP-binding cassette, sub-family B (MDR/TAP), member 11; Abcc2; ATP-binding cassette, sub-family C (CFTR/MRP), membe
The recessive model of MRP2 G1249A polymorphism decrease the risk of drug-resistant in Asian Epilepsy: A systematic review and meta-analysis
Keywords: ABCC2; Epilepsy; Drug-resistance; Meta-analysis; Asian
Transcriptomics profiling and steroid production in mummichog (Fundulus heteroclitus) testes after treatment with 5α-dihydrotestosterone
Keywords: 11KT; 11-ketotestosterone; ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; ABCC3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; ABCG8; ATP-binding cassette, sub-family G (WHITE), member 8; ACY1; aminoacylase 1; ADAR; adenosine d
Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells
Keywords: ABC; ATP-binding cassette; ABCC1; ATP-binding cassette, Sub-family C, Member 1; ABCC2; ATP-binding cassette, Sub-family C, Member 2; ABCG2; ATP-binding cassette, Sub-family G, Member 2; BCRP; breast cancer resistance protein; CDDP; cisplatin (cis-diammine
Impact of probe compound in MRP2 vesicular transport assays
Keywords: Drug transport; ABC transporter; Efflux; Membrane vesicle; MRP2; ABCC2
Common variants in ABCB1, ABCC2 and ABCG2 genes and clinical outcomes among women with advanced stage ovarian cancer treated with platinum and taxane-based chemotherapy: A Gynecologic Oncology Group study ★★★
Keywords: ABCB1; ABCC2; GOG; Advanced stage ovarian cancer; Common variants
The association of the UGT1A8, SLCO1B3 and ABCC2/ABCG2 genetic polymorphisms with the pharmacokinetics of mycophenolic acid and its phenolic glucuronide metabolite in Chinese individuals
Keywords: Mycophenolic acid; Pharmacokinetics; SLCO1B3; UGT1A8; ABCC2; ABCG2
Rat Mrp2 gene expression is regulated by an interleukin-1β-stimulated biphasic response with enhanced transcription and subcellular shuttling of YB-1
Keywords: IL-1β; interleukin 1β; YB-1; Y-box protein-1; LPS; lipopolysaccharide; RT; reverse transcriptase; Mrp2; multidrug-resistance protein 2; MMP-2; matrix metalloproteinase 2; TNFα; tumor necrosis factor α; CFP; cyan fluorescent protein; YFP; yellow fluore
Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment
Keywords: A - B; apical-to-basolateral; ABC transporters; ATP-binding cassette transporters; ABCB1; ATP-binding cassette transporter B1 gene (Pgp); ABCC2; ATP-binding cassette transporter C2 gene (MRP2); B - A; basolateral-to-apical; BCRP; breast cancer resista
Association of ABCC2 polymorphisms with platinum-based chemotherapy response and severe toxicity in non-small cell lung cancer patients
Keywords: Non-small cell lung cancer; Polymorphisms; ABCC2; Platinum; Response; Toxicity
Molecular characterization and functions of zebrafish ABCC2 in cellular efflux of heavy metals
Keywords: MRP; ABCC2; Heavy metals; Detoxification; Zebrafish;
Development of a fluorescence-based assay for drug interactions with human Multidrug Resistance Related Protein (MRP2; ABCC2) in MDCKII-MRP2 membrane vesicles
Keywords: MRP2; ABCC2; Fluorescence assay; ABC protein; Carboxydichlorofluorescein (CDF)
Genetic polymorphisms influence mycophenolate mofetil-related adverse events in pediatric heart transplant patients
Keywords: mycophenolate mofetil; adverse events; multidrug resistance protein 2; ABCC2; inosine monophosphate dehydrogenase 1; inosine monophosphate dehydrogenase 2; genetic polymorphism;
Synergistic influence of Abcb1 and Abcc2 on disposition and sterol lowering effects of ezetimibe in rats
Keywords: ezetimibe; disposition; ABCB1; ABCC2; MRP2; P-gp; transporter; PSC833;
Hyperbilirubinemia syndromes (Gilbert-Meulengracht, Crigler-Najjar, Dubin-Johnson, and Rotor syndrome)
Keywords: Hepatobiliary transport; Gilbert syndrome; Glucuronidation; Genotyping; Drug toxicity; ABCC2; UGT1A1; Jaundice
Integrated pharmacogenetic prediction of irinotecan pharmacokinetics and toxicity in patients with advanced non-small cell lung cancer
Keywords: UGT1A; ABCB1; ABCC2; ABCG2; OATP1B1; Irinotecan; NSCLC
Polymorphisms of MRP2 (ABCC2) are associated with susceptibility to nonalcoholic fatty liver disease
Keywords: Bile; Liver; MRP2; Multidrug-resistance-associated protein; Gene variant; ABCC2; Fatty liver disease; NASH
Cholesterol but not association with detergent resistant membranes is necessary for the transport function of MRP2/ABCC2
Keywords: ABCC2; HepG2; Raft; Triton X-100 insoluble fraction; Detergent resistant membrane
Compound profiling for ABCC2 (MRP2) using a fluorescent microplate assay system
Keywords: MRP2; ABCC2; CMFDA; Fluorescence assay; ABC-protein
RNA interference-triggered reversal of ABCC2-dependent cisplatin resistance in human cancer cells
Keywords: RNAi; ABCC2; MRP2; cMOAT; ABC-transporter; Cisplatin; Paclitaxel; Drug resistance
Bilirubin metabolism: Applied physiology
Keywords: Bilirubin; Bilirubin glucuronides; UGT1A1; ABCC2
Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response
Keywords: ABCB1; ABCC2; ABC transporter; SNP; Tumorigenesis; Xenobiotics
Pharmacogenetics of irinotecan metabolism and transport: An update
Keywords: CPT-11; SN-38; CYP3A; CES; UGT1A; ABCB1; ABCC1; ABCC2; ABCG2
Dual Hereditary Jaundice: Simultaneous Occurrence of Mutations Causing Gilbert's and Dubin-Johnson Syndrome
Keywords: ABCC2; ATP-binding cassette protein C2; BSP; bromosulphthalein; CEACAM1; CEA-related adhesion molecule 1; DAPI; 4',6-diamidino-2-phenylindole; DJS; Dubin-Johnson syndrome; GS; Gilbert's syndrome; HIDA; 2,6-dimethylacetanilido-iminodiacetic acid; MRP2;