Induction of ABCG2/BCRP restricts the distribution of zidovudine to the fetal brain in rats
Keywords: HIV; ABCG2; Zidovudine; Bioavailability; Placenta; Fetal brain;
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Modulating the function of ATP-binding cassette subfamily G member 2 (ABCG2) with inhibitor cabozantinib
Keywords: MDR; multidrug resistant; ABC transporter; ATP binding cassette transporter; ABCG2; ATP binding cassette subfamily G member 2; Cabozantinib; Breast cancer resistant protein; Multidrug resistance; ABC transporter;
Dual effects of the PI3K inhibitor ZSTK474 on multidrug efflux pumps in resistant cancer cells
Keywords: ZSTK474 (PubChem CID: 11647372); Vinblastine (PubChem CID: 241903); Mitoxantrone (PubChem CID: 4212); Calcein-AM (PubChem CID: 4126474); Nicardipine (PubChem CID: 4474); Fumetrimorgen C (PubChem CID: 403923); P-glycoprotein; ABCG2; ZSTK474; Multidrug resi
Cancer stem cells: Radioresistance, prediction of radiotherapy outcome and specific targets for combined treatments
Keywords: ABCG2; cATP-binding cassette sub-family G member 2; ALDH1A1; aldehyde dehydrogenase 1A1; ATM; ataxia telangiectasia mutated protein kinase; ATR; ATM-Rad-3-related protein kinase; CD; cluster of differentiation; CSC(s); cancer stem cell(s); Chk; checkpoint
Pyrrolopyrimidine derivatives and purine analogs as novel activators of Multidrug Resistance-associated Protein 1 (MRP1, ABCC1)
Keywords: ABC; ATP-binding cassette; ABCB1; synonymous for P-gp; ABCC1; synonymous for MRP1; ABCG2; synonymous for BCRP; APT; attached proton test; ATP; adenosine 5â²-triphosphate; BCECF; 2â².7â²-bis(2-carboxyethyl)-5-(and-6)-carboxyfluorescein; BCPCF; 3-carboxy
Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism
Keywords: ABCG2; chronic kidney disease; parathyroid hormone; secondary hyperparathyroidism; urate;
Effect of abemaciclib (LY2835219) on enhancement of chemotherapeutic agents in ABCB1 and ABCG2 overexpressing cells in vitro and in vivo
Keywords: MDR; multidrug resistance; DOX; doxorubicin; Rho 123; rhodamine 123; ABC; adenosine triphosphate (ATP)-binding cassette; ABCB1; ABC transporter subfamily B member 1; ABCG2; ABC transporter subfamily G member 2; CDK; cyclin D-cyclin dependent kinase; Rb; r
From ancient herb to modern drug: Artemisia annua and artemisinin for cancer therapy
Keywords: ABCB6; ATP-binding cassette transporter B6; ABCG2; ATP binding cassette transporter G2; AIF; apoptosis inducing factor; AKT; v-Akt murine thymoma viral oncogene homologue; AMPK; AMP-activated protein kinase; Ang-1; angiotensin 1; ARE; arteether; ARM; arte
The role of GLI2-ABCG2 signaling axis for 5Fu resistance in gastric cancer
Keywords: 5Fu; Gastric cancer; ABCG2; Hedgehog; Gli2;
R- and S-Warfarin Were Transported by Breast Cancer Resistance Protein: From In Vitro to Pharmacokinetic-Pharmacodynamic Studies
Keywords: ABC transporters; drug transport; mass spectrometry; preclinical pharmacokinetics; pharmacokinetics/pharmacodynamics; INR; international normalized ratio; BCRP; breast cancer resistance protein; ABCG2; ATP-binding cassette transporter G2; CYP450; cytochro
Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites
Keywords: ABC transporters; transporters; skin; P-glycoprotein; tissue partition; ABCB1; ATP binding cassette subfamily B member 1; ABCG2; ATP binding cassette subfamily G member 2; BCRP; breast cancer resistance protein; CRC; colorectal cancer; CYP3A4; cytochrome
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2)
Keywords: ABC transporter; Inhibitor; ABCG2; Quinazolines; BCRP;
Specific OCT1 and ABCG2 polymorphisms are associated with Lamotrigine concentrations in Chinese patients with epilepsy
Keywords: Lamotrigine; Pharmacogenetics; OCT1; ABCG2; ABCC2; HNF4α;
Cancer stem-like cell behavior in anaplastic thyroid cancer: A challenging dilemma
Keywords: Anaplastic thyroid cancer; Cancer stem cells; CD133; Nestin; ABCG2
Characterization of rabbit limbal epithelial side population cells using RNA sequencing and single-cell qRT-PCR
Keywords: Corneal epithelial stem cells; Limbal epithelial side population; RNA sequencing; Gene expression profile; Single-cell qRT-PCR; SP; Side population; Abcg2; ATP-binding cassette transporter subfamily G;
ABCG2, Cytogenetics, and Age Predict Relapse after Allogeneic Stem Cell Transplantation for Acute Myeloid Leukemia in Complete Remission
Keywords: ABCG2; Acute myeloid leukemia; Transplantation; Relapse
Low ABCB1 and high OCT1 levels play a favorable role in the molecular response to imatinib in CML patients in the community clinical practice
Keywords: Chronic myeloid leukemia; Imatinib; Sokal score; ABCB1/P-glycoprotein; ABCG2; OCT1;
The ABCG2 efflux transporter from rabbit placenta: Cloning and functional characterization
Keywords: ABCG2/BCRP efflux transporter; Placenta barrier; Rabbit; developmental toxicity testing; Active drug transport; MDCKII in vitro model; ABCG2; ATP-binding cassette sub-family G member 2; cDNA; complementary DNA; DMEM; Dulbecco's modified Eagle's medium; d
Assessment of ABCG2-mediated transport of pesticides across the rabbit placenta barrier using a novel MDCKII in vitro model
Keywords: ABCG2; ATP-binding cassette sub-family G member 2; CPF; chlorpyrifos; DAPI; 4â²-6-diamidino-2-phenylindole; FTC; fumitremorgin C; MDCKII; Madin-Darby canine kidney type II cells; MRL; maximum residue limits; Papp; apparent permeability coefficient; TEER;
Plasma membrane dynamics and tetrameric organisation of ABCG2 transporters in mammalian cells revealed by single particle imaging techniques
Keywords: ABCG2; Oligomerisation; Fluorescence correlation spectroscopy; Photon counting histogram; Total internal reflection fluorescence; Stepwise photobleaching;
Gastrin regulates ABCG2 to promote the migration, invasion and side populations in pancreatic cancer cells via activation of NF-κB signaling
Keywords: Gastrin; ABCG2; Side population cell; Pancreatic cancer;
Functional characterization of the ABCG2 5â² non-coding exon variants: Stem cell specificity, translation efficiency and the influence of drug selection
Keywords: ABCG2; Noncoding exons; 5â² UTR; Alternative promoters; MCF-7; Stem cell;
Novel insights into the response of Atlantic salmon (Salmo salar) to Piscirickettsia salmonis: Interplay of coding genes and lncRNAs during bacterial infection
Keywords: Salmo salar; Piscirickettsia salmonis; RNA-Seq; SRS; lncRNAs; Abcg2; ATP-binding cassette sub-family G member 2; ARF6; ADP-ribosylation factor 6b; dpi; days post-injection; ISAv; infectious salmon anemia virus infection; lncRNAs; long non-coding RNAs; SRS
Phenyltetrazolyl-phenylamides: Substituent impact on modulation capability and selectivity toward the efflux protein ABCG2 and investigation of interaction with the transporter
Keywords: ABC-transporter; ABCG2; BCRP inhibitor; Synthesis; Structure-activity relationship; Enzyme kinetics; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein (ABCG2); CsA; cyclosporine A; FTC; fumitremorgin C; Imax; maximal inhibition; i-Pr; isop
The combination of quinazoline and chalcone moieties leads to novel potent heterodimeric modulators of breast cancer resistance protein (BCRP/ABCG2)
Keywords: ABC transporter; ABCG2; Multidrug resistance; Chalcones; Quinazolines; Quinazoline-chalcones; Pheophorbide A assay; ATPase; ABC; ATP-binding cassette; BCRP; breast cancer resistance protein;
Effects of the ABCG2 and ABCB1 drug transporter polymorphisms on the pharmacokinetics of bicalutamide in humans
Keywords: Bicalutamide; Prostate cancer; ABCB1; P-glycoprotein; BCRP; ABCG2;
Short communication: The gain-of-function Y581S polymorphism of the ABCG2 transporter increases secretion into milk of danofloxacin at the therapeutic dose for mastitis treatment
Keywords: ABCG2; polymorphism; danofloxacin; milk secretion;
Association of KEAP1 and NFE2L2 polymorphisms with temporal lobe epilepsy and drug resistant epilepsy
Keywords: AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ABCG2; ATP-binding cassette transporter protein; bal acc; balanced accuracy; CI; confidence interval; HER2CA; constitutively active human epidermal growth factor receptor 2; CV; cross validation
Polymorphisms of ABCG2, ABCB1 and HNF4α are associated with Lamotrigine trough concentrations in epilepsy patients
Keywords: Lamotrigine; Pharmacogenetics; ABCG2; HNF4α; ABCB1
Cholesterol reduces the sensitivity to platinum-based chemotherapy via upregulating ABCG2 in lung adenocarcinoma
Keywords: Cholesterol; Chemosensitivity; Lung adenocarcinoma; ABCG2;
Organic anion transporter 4 (OAT 4) modifies placental transfer of perfluorinated alkyl acids PFOS and PFOA in human placental ex vivo perfusion system
Keywords: PFAA; ABCG2; OAT4; Perfluoro octane sulphonate; Perfluoro octanoate; Fetal exposure
Relationship Among Gefitinib Exposure, Polymorphisms of Its Metabolizing Enzymes and Transporters, and Side Effects in Japanese Patients With Non–Small-Cell Lung Cancer
Keywords: ABCG2; CYP2D6; Gefitinib; Hepatotoxicity; Trough concentration
Elacridar enhances the cytotoxic effects of sunitinib and prevents multidrug resistance in renal carcinoma cells
Keywords: Sunitinib (Sutent) (PubChem CID: 5329102)Renal cell carcinoma; Drug resistance; Sunitinib; P-glycoprotein; ABCG2
Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44+/Musashi-1+ gastric cancer stem cells
Keywords: Chemoresistance; Gastric cancer xenograft; SHH-GLI; ABCG2;
ABCG2 Localizes to the Nucleus and Modulates CDH1 Expression in Lung Cancer Cells
Keywords: ABCG2; ATP-binding cassette subfamily G member 2; CDH1; E-cadherin; ChIP; chromatin immunoprecipitation; CSC; cancer stem cell; EMT; epithelial-mesenchymal transition; EMSA; electrophoretic mobility shift assay; MET; mesenchymal-epithelial transition; NLS
Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP/ABCB1) and breast cancer resistance protein (BCRP/ABCG2)
Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; AUC; area under the plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; Cmax; maximum drug concentration in plasma; EML4; echinoderm microtubule-ass
Collateral sensitivity: ABCG2-overexpressing cells are more vulnerable to oxidative stress
Keywords: ABCG2; BCRP; Oxidative stress; GSH; Multidrug resistance; Free radicals;
Association of genotypes and haplotypes of multi-drug transporter genes ABCB1 and ABCG2 with clinical response to imatinib mesylate in chronic myeloid leukemia patients
Keywords: ABCB1; ABCG2; Chronic myeloid leukemia; Imatinib mesylate; Single nucleotide polymorphisms
Impact of genetic variability in the ABCG2 gene on ABCG2 expression, function, and interaction with AT1 receptor antagonist telmisartan
Keywords: ATP-binding cassette (ABC) transporter; ABCG2; Telmisartan; AT1 receptor antagonists; Polymorphism;
AST1306, a potent EGFR inhibitor, antagonizes ATP-binding cassette subfamily G member 2-mediated multidrug resistance
Keywords: AST1306; ATP-binding cassette transporters; Multidrug resistance; ABCG2;
Baicalein decreases side population proportion via inhibition of ABCG2 in multiple myeloma cell line RPMI 8226 in vitro
Keywords: Baicalein; Multiple myeloma; Side population; ABCG2; Baicalein (PubChem CID: 5281605); Methyl sulfoxide (DMSO) (PubChem CID: 679); Fumitremorgin C (FTC) (PubChem CID: 403923); Propidium iodide (PI) (PubChem CID: 104981);
Identification and expression pattern of two novel alternative splicing variants of EEF1D gene of dairy cattle
Keywords: eEF1; eukaryotic elongation factor 1; eEF1A; eukaryotic elongation factor 1A; eEF1B; eukaryotic elongation factor 1B; eEF1Bγ; eukaryotic elongation factor 1γ; eEF1Bα; eukaryotic elongation factor 1α; eEF1Bδ; eukaryotic elongation factor 1Bδ; EEF1D;
Linsitinib (OSI-906) antagonizes ATP-binding cassette subfamily G member 2 and subfamily C member 10-mediated drug resistance
Keywords: Linsitinib; Multi-drug resistance; ABCG2; ABCC10; Tyrosine kinase inhibitor;
Characterization of 3-methoxy flavones for their interaction with ABCG2 as suggested by ATPase activity
Keywords: ABCG2; BCRP; Flavonoids; Substrate; ATPase;
Telatinib reverses chemotherapeutic multidrug resistance mediated by ABCG2 efflux transporter in vitro and in vivo
Keywords: ABC, ATP-binding cassette; ABCB1, ABC transporter-subfamily B member 1; ABCG2, ABC transporter-subfamily G member 2; MDR, multidrug resistance; VEGFR, vascular endothelial growth factor receptor; TKI, tyrosine kinase inhibitorABC transporter; ABCG2; Multi
Motesanib (AMG706), a potent multikinase inhibitor, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1
Keywords: MDR; multidrug resistance; ABC; ATP-binding cassette; ABCB1; ABC transporter subfamily B member 1; ABCG2; ABC transporter subfamily G member 2; VEGFR; vascular endothelial growth factor receptor; TKI; tyrosine kinase inhibitor; Multidrug resistance; ABC t
CEP-33779 antagonizes ATP-binding cassette subfamily B member 1 mediated multidrug resistance by inhibiting its transport function
Keywords: ABC; ATP-binding cassette; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; CSCs; Cancer stem cell; DOX; doxorubicin; FTC; fumitremorgin C; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; Rho123; Rhodamine 123; M
Multidrug resistance (MDR) reversers: High activity and efficacy in a series of asymmetrical N,N-bis(alkanol)amine aryl esters
Keywords: MDR reversers; P-gp inhibitors; N,N-bis(alkanol)amine aryl esters; Chemosensitizers; Doxorubicin-resistant erythroleukemia K562 cells (K562/DOX); Pirarubicin uptake; P-gp; P-glycoprotein; BCRP; breast cancer resistance protein; MRP1; multidrug resistance-
Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells
Keywords: ABC; ATP-binding cassette; ABCC1; ATP-binding cassette, Sub-family C, Member 1; ABCC2; ATP-binding cassette, Sub-family C, Member 2; ABCG2; ATP-binding cassette, Sub-family G, Member 2; BCRP; breast cancer resistance protein; CDDP; cisplatin (cis-diammine
The ABCG2 transporter is a key molecular determinant of the efficacy of sonodynamic therapy with Photofrin in glioma stem-like cells
Keywords: Sonodynamic therapy; Glioma stem-like cells; ABCG2; Photofrin; Antitumor efficiency;