دانلود مقالات ISI درباره جذب، توزیع، متابولیسم و ​​دفع + ترجمه فارسی

کشف بنزیدیازول آمید به عنوان آنتی باکتری های قوی

Discovery of benzothiazole amides as potent antimycobacterial agents

Keywords: جذب، توزیع، متابولیسم و ​​دفع; NTM; nontuberculous mycobacteria; Mtb; Mycobacterium tuberculosis; SAR; structure activity relationship; Mbs; Mycobacterium abscessus ATCC 19977; MIC; minimum inhibitory concentration; RHS; right hand side; LHS; left hand side; ADME; absorption, distribut

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2018 سفارش ترجمه

تعیین حداکثر دوز تحمل شده برای یک مطالعه 2 ساله موش صحرایی / سرطان زا، با استفاده از تفاوت جنسیتی سم زدایی و سمیت

Establishing maximum tolerated doses for a 2-year combined chronic/carcinogenicity rat study based on toxicokinetic and toxicity gender differences

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Maximum tolerated dose; Chronic toxicity; Carcinogenicity; Toxicokinetics; Gender difference; ADME; absorption, distribution, metabolism, and excretion; AUCs; areas under the curve; Cmax; maximum concentration; KMD; kinetically-derived maximum dose; MTD;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

مقاله پژوهشی طراحی، سنتز و ارزیابی بیولوژیکی مشتقات آمینو فسفونات به عنوان فعال کننده گلوکوکیناز انسانی مبتنی بر ساختار

Research ArticleStructure based design, synthesis and biological evaluation of amino phosphonate derivatives as human glucokinase activators

Keywords: جذب، توزیع، متابولیسم و ​​دفع; GK; Glucokinase; GKA; glucokinase activators; QSAR; Quantitative Structure Activity Relationship; RMSE; root mean square error; RMSD; root mean square devaition; ADME; absorption, distribution, metabolism, and excretion; IR; infra red; NMR; nuclear magnet

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

طراحی، سنتز و ارزیابی بیولوژیکی مهار کننده های رنین با هدایت شبیه سازی شده شبیه سازی شبیه سازی پتانسیل شیمیایی

Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations

Keywords: جذب، توزیع، متابولیسم و ​​دفع; SACP; simulated annealing of chemical potential; CFA; constrained fragment analysis; FE Pred; predicted relative free energy; ΔΔGs; relative solvation change; D5W; 5% dextrose (glucose) in water; Vdss; steady-state volume of distribution; Cl; clearance;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

ارزیابی حمل و نقل در توسعه دارویی: وضعیت فعلی و مسائل معاصر

Evaluation of transporters in drug development: Current status and contemporary issues

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; AUC; area under concentration-time curve; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CFTR; cystic fibrosis transmembrane conductance regulator; Cmax; maximal plasma conce

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

ایمنی نانوذرات در تحویل دارو

Safety of nanosuspensions in drug delivery

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Nanosuspension; Safety; Nanotoxicology; Sterilization; Drug delivery; NCEs; new chemical entities; MTD; maximum tolerated doses; IV; intravenous; MPS; mononuclear phagocyte system; EPR; enhanced permeability and retention; HPMC; hydroxy propyl methyl cell

دانلود رایگان متن کامل مقاله ISI 64 صفحه سال انتشار : 2017 سفارش ترجمه

متابولومیک و پتانسیل آن در توسعه دارو

Metabolomics and its potential in drug development

Keywords: جذب، توزیع، متابولیسم و ​​دفع; MS; mass spectrometry; UPLC; ultraperformance liquid chromatography; UPLC-ESI-QTOFMS; UPLC-electrospray ionization-quadrupole time-of-flight MS; LCMS; liquid chromatography-mass spectrometry; GCMS; gas chromatography-mass spectrometry; NMR; nuclea

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

An integrated computational hierarchy for identification of potent inhibitors against Shikimate Kinase enzyme from Shigella sonnei, a major cause of global dysentery

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ATP; adenosine triphosphate; SK; Shikimate Kinase; PDB; Protein Data Bank; GOLD; Genetic Optimization for Ligand Docking; VMD; Visual Molecular Dynamics; DS; Discovery Studio; PRDOS; Protein DisOrder prediction System; PK; pharmacokinetics; BBB; blood-bra

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11760 loaded polylactic acid-polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Nanoparticles; PLA-PEG; Oxazolidinone; Staphylococcus aureus; Antibacterial; Nanomedicine; ATCC; American type culture collection; ATR-FTIR; attenuated total reflectance-Fourier transforms infrared spectroscopy; ACN; acetonitrile; ADME; absorption, dist

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Breath research; Exhaled breath condensate (EBC); Exhaled breath aerosol (EBA); Volatile organic compounds (VOCs); Analytical techniques; Biomarkers; 1D; one-dimensional; ADME; absorption, distribution, metabolism, and excretion; AOP; adverse outcome path

دانلود رایگان متن کامل مقاله ISI 70 صفحه سال انتشار : 2018 سفارش ترجمه

Drug-likeness prediction of chemical constituents isolated from Chinese materia medica Ciwujia

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; AS; Acanthopanax senticosus harms; BBB; blood-brain barrier; CMM; Chinese materia medica; CNS; central nervous system; CWJ; Ciwujia; ERK; extracellular signal-regulated kinase; HIA; human intestin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Ac; acetyl; ADME; absorption, distribution, metabolism, and excretion; aq.; aqueous; AUC; total area under the blood concentration-time curve; bid; bis in die (twice per day); Boc; (tert-butoxy)carbonyl; Bu; butyl; Bz; benzoyl; cLogP; calculate logarith

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of the hypoglycemic potential of a black bean hydrolyzed protein isolate and its pure peptides using in silico, in vitro and in vivo approaches

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Black bean; Hydrolyzed protein isolate; Diabetes; Glucose absorption; Glucose transporters; Hyperglycemic rats; Glibenclamide: PubChem CID: 3488.; Glucose: PubChem CID: 10954115.; Metformin: PubChem CID: 4091.; Phloretin: PubChem CID: 4788.; Streptozotoci

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study

Keywords: جذب، توزیع، متابولیسم و ​​دفع; 17β-Hydroxysteroid dehydrogenase type 1; Enzyme inhibitor; Steroidogenic enzymes; Estrogen-dependent disease; Intracrinology; (h)17β-HSD1; (human) 17β-hydroxysteroid dehydrogenase type 1; (h)17β-HSD2; (human) 17β-hydroxysteroid dehydrogenase type 2;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Timosaponin BII; Toxicity; Toxicokinetics; NOAEL; Rats; 1H NMR; 1H nuclear magnetic resonance; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism, and excretion; ADP; adenosine diphosphate; ALB; albumin; ALP; alkaline phosphatase; ALT; al

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

The silymarin composition… and why does it matter???

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; ASTM; American Society for Testing and Materials; NHDF; normal human dermal fibroblasts; NHEK; normal human epidermal keratinocytes; PE; petroleum ether; LC-MS; liquid chromatography-mass spectr

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

A 90-day oral toxicity study of glycolipids from Dacryopinax spathularia in CD® rats

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Oral; Subchronic toxicity; Rat; Jelly mushroom glycolipids; Natural preservative; Absorption, distribution, metabolism, and excretion; (ADME); activated partial thromboplastin time; (aPTT); alanine amino-transferase; (ALAT); alkaline phosphatase; (AP); as

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; AML; acute myelogenous leukemia; AUC; area under the blood concentration time curve; b.i.d.; twice a day; CDK; Cyclin-dependent kinase; CLtotal; clearance; Cmax; maximum drug concentration; CRC; c

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; AMS; accelerator mass spectrometry; AUC; area under the plasma concentration-time curve from zero to infinity; AUC[0-t]; area under the plasma concentration-time curves from zero to time t;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Mtb; Mycobacterium tuberculosis; TB; Tuberculosis; MDR-TB; Multidrug-resistant tuberculosis; RIF; Rifampicin; INH; Isoniazid; PZA; Pyrazinamide; ETH; Ethambutol; WHO; World Health Organization; CYP; Cytochrome P450; ADME; Absorption, distribution, metabol

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EMSA; Electrophoretic Mobility Shift Assay; Erk; extracellular-signal-related kinase; FBS; foetal bovine serum; GAPDH; glyce

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Keywords: جذب، توزیع، متابولیسم و ​​دفع; 17β-Hydroxysteroid dehydrogenase type 1; Interspecies differences; Estrogen-dependent diseases; Estrogen mimetics; Non-steroidal inhibitors; 17β-HSD1; 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2; 17β-hydroxysteroid dehydrogenase type 2; E1; est

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative in vitro to in vivo extrapolation of tissues toxicity

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part II: Importance of physicochemical properties and dose in animal and in vitro studies as a basis for risk assessment

Keywords: جذب، توزیع، متابولیسم و ​​دفع; MoM; Metal-on-metal; CoCr; Cobalt-chromium-molybdenum alloy; Co; Cobalt; Cr; Chromium; ADME; Absorption, distribution, metabolism, and excretion; ALVAL; Aseptic lymphocyte dominated vasculitis associated lesion; NAS; National Academy of Sciences; LOAEL; L

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

Estimation of the chemical-induced eye injury using a weight-of-evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): Part I: Irritation potential

Keywords: جذب، توزیع، متابولیسم و ​​دفع; 3Rs; refinement, reduction and replacement; AD; applicability domain; ADME; absorption, distribution, metabolism, and excretion; ANN; artificial neural network; ANNE; artificial neural network ensemble; Architecture; particular combination of neurons and

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; AMLV; amphotropic murine leukemia virus; BBB; blood-brain barrier; BIF; bioisostere factor; CNS; central nervous system; DCM; dichloromethane; DiEA; diisopropylethylamine; DIPEA; N,N-diisopropyl

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

The Combination of MK-5172, Peginterferon, and Ribavirin Is Effective in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection Without Cirrhosis

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Response-Guided Therapy; Sustained Virologic Response; Chronic HCV; Protease Inhibitor; ADME; absorption, distribution, metabolism, and excretion; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BOC; boceprevir; cEVR; complete early virolo

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2014 سفارش ترجمه

An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; COX; cyclooxygenase; DPPD; N,N′-diphenyl-p-phenylenediamine; HPV; high production volume; NSAID; non-steroidal anti-inflammatory drug; OECD; Organisation for Economic Co-operation and Developmen

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Identification and validation of bioactive small molecule target through phenotypic screening

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; CsA; cyclosporin A; HBC; 4-[3,5-bis-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-4,5-dihydro-pyrazol-1-yl]-benzoic acid; HDAC; histone deacetylase; HUVEC; human umbilical vascular endothelial cell; KF;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Keywords: جذب، توزیع، متابولیسم و ​​دفع; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors

Keywords: جذب، توزیع، متابولیسم و ​​دفع; ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه