Keywords: جذب، توزیع، متابولیسم و دفع; NTM; nontuberculous mycobacteria; Mtb; Mycobacterium tuberculosis; SAR; structure activity relationship; Mbs; Mycobacterium abscessus ATCC 19977; MIC; minimum inhibitory concentration; RHS; right hand side; LHS; left hand side; ADME; absorption, distribut
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Keywords: جذب، توزیع، متابولیسم و دفع; Maximum tolerated dose; Chronic toxicity; Carcinogenicity; Toxicokinetics; Gender difference; ADME; absorption, distribution, metabolism, and excretion; AUCs; areas under the curve; Cmax; maximum concentration; KMD; kinetically-derived maximum dose; MTD;
Keywords: جذب، توزیع، متابولیسم و دفع; GK; Glucokinase; GKA; glucokinase activators; QSAR; Quantitative Structure Activity Relationship; RMSE; root mean square error; RMSD; root mean square devaition; ADME; absorption, distribution, metabolism, and excretion; IR; infra red; NMR; nuclear magnet
Keywords: جذب، توزیع، متابولیسم و دفع; SACP; simulated annealing of chemical potential; CFA; constrained fragment analysis; FE Pred; predicted relative free energy; ÎÎGs; relative solvation change; D5W; 5% dextrose (glucose) in water; Vdss; steady-state volume of distribution; Cl; clearance;
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; AUC; area under concentration-time curve; BCRP; breast cancer resistance protein; BSEP; bile salt export pump; CFTR; cystic fibrosis transmembrane conductance regulator; Cmax; maximal plasma conce
Keywords: جذب، توزیع، متابولیسم و دفع; Nanosuspension; Safety; Nanotoxicology; Sterilization; Drug delivery; NCEs; new chemical entities; MTD; maximum tolerated doses; IV; intravenous; MPS; mononuclear phagocyte system; EPR; enhanced permeability and retention; HPMC; hydroxy propyl methyl cell
Keywords: جذب، توزیع، متابولیسم و دفع; MS; mass spectrometry; UPLC; ultraperformance liquid chromatography; UPLC-ESI-QTOFMS; UPLC-electrospray ionization-quadrupole time-of-flight MS; LCMS; liquid chromatography-mass spectrometry; GCMS; gas chromatography-mass spectrometry; NMR; nuclea
An integrated computational hierarchy for identification of potent inhibitors against Shikimate Kinase enzyme from Shigella sonnei, a major cause of global dysentery
Keywords: جذب، توزیع، متابولیسم و دفع; ATP; adenosine triphosphate; SK; Shikimate Kinase; PDB; Protein Data Bank; GOLD; Genetic Optimization for Ligand Docking; VMD; Visual Molecular Dynamics; DS; Discovery Studio; PRDOS; Protein DisOrder prediction System; PK; pharmacokinetics; BBB; blood-bra
In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11760 loaded polylactic acid-polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus
Keywords: جذب، توزیع، متابولیسم و دفع; Nanoparticles; PLA-PEG; Oxazolidinone; Staphylococcus aureus; Antibacterial; Nanomedicine; ATCC; American type culture collection; ATR-FTIR; attenuated total reflectance-Fourier transforms infrared spectroscopy; ACN; acetonitrile; ADME; absorption, dist
Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols
Keywords: جذب، توزیع، متابولیسم و دفع; Breath research; Exhaled breath condensate (EBC); Exhaled breath aerosol (EBA); Volatile organic compounds (VOCs); Analytical techniques; Biomarkers; 1D; one-dimensional; ADME; absorption, distribution, metabolism, and excretion; AOP; adverse outcome path
Drug-likeness prediction of chemical constituents isolated from Chineseâmateriaâmedica Ciwujia
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; AS; Acanthopanax senticosus harms; BBB; blood-brain barrier; CMM; Chinese materia medica; CNS; central nervous system; CWJ; Ciwujia; ERK; extracellular signal-regulated kinase; HIA; human intestin
Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents
Keywords: جذب، توزیع، متابولیسم و دفع; Ac; acetyl; ADME; absorption, distribution, metabolism, and excretion; aq.; aqueous; AUC; total area under the blood concentration-time curve; bid; bis in die (twice per day); Boc; (tert-butoxy)carbonyl; Bu; butyl; Bz; benzoyl; cLogP; calculate logarith
Evaluation of the hypoglycemic potential of a black bean hydrolyzed protein isolate and its pure peptides using in silico, in vitro and in vivo approaches
Keywords: جذب، توزیع، متابولیسم و دفع; Black bean; Hydrolyzed protein isolate; Diabetes; Glucose absorption; Glucose transporters; Hyperglycemic rats; Glibenclamide: PubChem CID: 3488.; Glucose: PubChem CID: 10954115.; Metformin: PubChem CID: 4091.; Phloretin: PubChem CID: 4788.; Streptozotoci
Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17β-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study
Keywords: جذب، توزیع، متابولیسم و دفع; 17β-Hydroxysteroid dehydrogenase type 1; Enzyme inhibitor; Steroidogenic enzymes; Estrogen-dependent disease; Intracrinology; (h)17β-HSD1; (human) 17β-hydroxysteroid dehydrogenase type 1; (h)17β-HSD2; (human) 17β-hydroxysteroid dehydrogenase type 2;
Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats
Keywords: جذب، توزیع، متابولیسم و دفع; Timosaponin BII; Toxicity; Toxicokinetics; NOAEL; Rats; 1H NMR; 1H nuclear magnetic resonance; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism, and excretion; ADP; adenosine diphosphate; ALB; albumin; ALP; alkaline phosphatase; ALT; al
The silymarin composition⦠and why does it matter???
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; ASTM; American Society for Testing and Materials; NHDF; normal human dermal fibroblasts; NHEK; normal human epidermal keratinocytes; PE; petroleum ether; LC-MS; liquid chromatography-mass spectr
A 90-day oral toxicity study of glycolipids from Dacryopinax spathularia in CD® rats
Keywords: جذب، توزیع، متابولیسم و دفع; Oral; Subchronic toxicity; Rat; Jelly mushroom glycolipids; Natural preservative; Absorption, distribution, metabolism, and excretion; (ADME); activated partial thromboplastin time; (aPTT); alanine amino-transferase; (ALAT); alkaline phosphatase; (AP); as
Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; AML; acute myelogenous leukemia; AUC; area under the blood concentration time curve; b.i.d.; twice a day; CDK; Cyclin-dependent kinase; CLtotal; clearance; Cmax; maximum drug concentration; CRC; c
Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; AMS; accelerator mass spectrometry; AUC; area under the plasma concentration-time curve from zero to infinity; AUC[0-t]; area under the plasma concentration-time curves from zero to time t;
New agents for the treatment of drug-resistant Mycobacterium tuberculosis
Keywords: جذب، توزیع، متابولیسم و دفع; Mtb; Mycobacterium tuberculosis; TB; Tuberculosis; MDR-TB; Multidrug-resistant tuberculosis; RIF; Rifampicin; INH; Isoniazid; PZA; Pyrazinamide; ETH; Ethambutol; WHO; World Health Organization; CYP; Cytochrome P450; ADME; Absorption, distribution, metabol
Novel non-peptide small molecules preventing IKKβ/NEMO association inhibit NF-κB activation in LPS-stimulated J774 macrophages
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EMSA; Electrophoretic Mobility Shift Assay; Erk; extracellular-signal-related kinase; FBS; foetal bovine serum; GAPDH; glyce
Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme
Keywords: جذب، توزیع، متابولیسم و دفع; 17β-Hydroxysteroid dehydrogenase type 1; Interspecies differences; Estrogen-dependent diseases; Estrogen mimetics; Non-steroidal inhibitors; 17β-HSD1; 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2; 17β-hydroxysteroid dehydrogenase type 2; E1; est
Quantitative in vitro to in vivo extrapolation of tissues toxicity
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst
Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part II: Importance of physicochemical properties and dose in animal and in vitro studies as a basis for risk assessment
Keywords: جذب، توزیع، متابولیسم و دفع; MoM; Metal-on-metal; CoCr; Cobalt-chromium-molybdenum alloy; Co; Cobalt; Cr; Chromium; ADME; Absorption, distribution, metabolism, and excretion; ALVAL; Aseptic lymphocyte dominated vasculitis associated lesion; NAS; National Academy of Sciences; LOAEL; L
Estimation of the chemical-induced eye injury using a weight-of-evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): Part I: Irritation potential
Keywords: جذب، توزیع، متابولیسم و دفع; 3Rs; refinement, reduction and replacement; AD; applicability domain; ADME; absorption, distribution, metabolism, and excretion; ANN; artificial neural network; ANNE; artificial neural network ensemble; Architecture; particular combination of neurons and
Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; AMLV; amphotropic murine leukemia virus; BBB; blood-brain barrier; BIF; bioisostere factor; CNS; central nervous system; DCM; dichloromethane; DiEA; diisopropylethylamine; DIPEA; N,N-diisopropyl
The Combination of MK-5172, Peginterferon, and Ribavirin Is Effective in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection Without Cirrhosis
Keywords: جذب، توزیع، متابولیسم و دفع; Response-Guided Therapy; Sustained Virologic Response; Chronic HCV; Protease Inhibitor; ADME; absorption, distribution, metabolism, and excretion; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BOC; boceprevir; cEVR; complete early virolo
An antioxidant, N,Nâ²-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; COX; cyclooxygenase; DPPD; N,Nâ²-diphenyl-p-phenylenediamine; HPV; high production volume; NSAID; non-steroidal anti-inflammatory drug; OECD; Organisation for Economic Co-operation and Developmen
Identification and validation of bioactive small molecule target through phenotypic screening
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; CsA; cyclosporin A; HBC; 4-[3,5-bis-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-4,5-dihydro-pyrazol-1-yl]-benzoic acid; HDAC; histone deacetylase; HUVEC; human umbilical vascular endothelial cell; KF;
Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
Keywords: جذب، توزیع، متابولیسم و دفع; Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch
Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors
Keywords: جذب، توزیع، متابولیسم و دفع; ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A