دانلود مقالات ISI درباره Achbp + ترجمه فارسی

جاذب های خاصی برای آنتی بادی های میاستنی گراوی با استفاده از جهش های دامنه خارج سلولی گیرنده استیک کولین عضله نیکوتین

Specific adsorbents for myasthenia gravis autoantibodies using mutants of the muscle nicotinic acetylcholine receptor extracellular domains

Keywords: MG; myasthenia gravis; AChR; nicotinic acetylcholine receptor; ECD; extracellular domain; MIR; main immunogenic region; AChBP; acetylcholine binding protein; α-Btx; α-bungarotoxin.; Nicotinic acetylcholine receptor; Extracellular domain; Myasthenia grav

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

گردش کار تحلیلی برای غربالگری سریع و تخلیه زیست فعال از پروتئوم سم

Analytical workflow for rapid screening and purification of bioactives from venom proteomes

Keywords: On-line microfluidics; Nano-liquid chromatography-mass spectrometry (nano-LC-MS); Snake venom proteome screening; Venom purification; Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP); Nicotinic acetylcholine receptor; ACN; acetonitrile; AChB

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

یک پلتفورم تحلیلی کارآمد برای پروفیل میکروفلوئیدیک روی مارهای مارپیچی ناخوشایند نسبت به میل جنسی گیرنده نیکوتین

An efficient analytical platform for on-line microfluidic profiling of neuroactive snake venoms towards nicotinic receptor affinity

Keywords: On-line microfluidics; Nano-liquid chromatography-mass spectrometry (nano-LC-MS); Snake venom proteome screening; Venomics; Lymnaea stagnalis acetylcholine binding protein (Ls-AChBP); Nicotinic acetylcholine receptor; AChBP; Acetylcholine binding prot

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling

Keywords: Microfluidic HRS; Neurotoxicity fingerprinting; AChBP; α7-nAChR; On-line bioaffinity; Nanolc-MS; Elapid venom profiling;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB

Keywords: ACh; acetylcholine; AChBP; acetylcholine-binding protein; ECD; extracellular domain; gAuIB; globular AuIB; ICD; intracellular domain; nAChR; nicotinic acetylcholine receptor; rAuIB; ribbon AuIB; SAR; structure-activity relationship; TMD; transmembrane dom

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

The binding orientation of epibatidine at α7 nACh receptors

Keywords: Cys-loop; Ion channel; Radioligand; Epibatidine; Agonist; α7 nACh; Nicotinic; Receptor; AChBP; 5-HT; 5-hydroxytryptamine; nACh; nicotinic acetylcholine; GABA; gamma-aminobutyric acid; HEK; human embryonic kidney; AChBP; acetylcholine binding protein; 5HT

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Characterization of a reproducible rat EAMG model induced with various human acetylcholine receptor domains

Keywords: MG; myasthenia gravis; AChR; nicotinic acetylcholine receptor; ECD; extracellular domain; MIR; main immunogenic region; AChBP; acetylcholine binding protein; α-Btx; α-bungarotoxin; EAMG; experimental autoimmune myasthenia gravis; EMG; electromyography;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Functional characterization of two prokaryotic pentameric ligand-gated ion channel chimeras - role of the GLIC transmembrane domain in proton sensing

Keywords: 5HT3R; serotonin receptor; α-BTX; α-bungarotoxin; AChBP; acetylcholine-binding protein; ECD; extracellular domain; ELIC; Erwinia ligand-gated ion channel; GLIC; Gloebacter ligand-gated ion channel; GlyR; glycine receptor; nAChR; nicotinic acetylcholine

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Assessment of the functionality and stability of detergent purified nAChR from Torpedo using lipidic matrixes and macroscopic electrophysiology

Keywords: nAChR-DCs; nicotinic acetylcholine receptors detergent complexes; Tc; Torpedo californica; Tm; Torpedo marmorata; PLB; planar lipid bilayer; TEVC; two electrode voltage clamp; LCP; Lipidic Cubic Phase; FC; foscholine family 12-16 carbon chain; LFC; lyso

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological activities of indolizine derivatives as alpha-7 nAChR agonists

Keywords: α7 nAChR; Indolizine; Agonists; SAR; Schizophrenia; ACh; acetylcholine; THF; tetrahydrofuran; DMSO; dimethylsulfoxide; CNS; central nervous system; HRMS; high resolution mass; DIPEA; diisopropylethylamine; AChBP; acetylcholine binding protein; SAR; struc

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

Biomolecular recognition of antagonists by α7 nicotinic acetylcholine receptor: Antagonistic mechanism and structure-activity relationships studies

Keywords: AChBP; acetylcholine binding protein; Ala; alanine; Arg; arginine; ATP; adenosine triphosphate; CNS; central nervous system; CoMFA; comparative molecular field analysis; CoMSIA; comparative molecular similarity indices analysis; Cys; cysteine; 3D-QSAR; th

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Exploration of the molecular architecture of the orthosteric binding site in the α4β2 nicotinic acetylcholine receptor with analogs of 3-(dimethylamino)butyl dimethylcarbamate (DMABC) and 1-(pyridin-3-yl)-1,4-diazepane

Keywords: nACh receptor agonists; Structure-activity studies; Ls-AChBP; Ac-AChBP; Lobeline; DMABC analogs; Ac; Aplysia californica; ACh; acetylcholine; AChBP; acetylcholine binding protein; CNS; central nervous system; CDI; 1,1′-carbonyldiimidazole; Ct; Capitel

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2015 سفارش ترجمه

The binding characteristics and orientation of a novel radioligand with distinct properties at 5-HT3A and 5-HT3AB receptors

Keywords: Antagonist; Cys-loop; Ion channel; Radioligand; 5-HT3; Agonist; 5-HT; 5-hydroxytryptamine; nACh; nicotinic acetylcholine; GABA; gamma-aminobutyric acid; HEK; human embryonic kidney; AChBP; acetylcholine binding protein; 5HTBP; an AChBP mutant modified to

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Pharmacological properties and predicted binding mode of arylmethylene quinuclidine-like derivatives at the α3β4 nicotinic acetylcholine receptor (nAChR)

Keywords: ACHBP; acetylcholine-binding protein; Ach; acetylcholine; CNS; central nervous system; MEC; minimum-effective concentration; nAChR; nicotinic acetylcholine receptor; NIC; nicotine; Pdb; protein databank; rmsd; root-mean-squared-deviation; ROC; receiver op

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

QM-polarized ligand docking accurately predicts the trend in binding affinity of a series of arylmethylene quinuclidine-like derivatives at the α4β2 and α3β4 nicotinic acetylcholine receptors (nAChRs)

Keywords: ACHBP; acetylcholine-binding protein; Ach; acetylcholine; CNS; central nervous system; MEC; minimum-effective concentration; nAChR; nicotinic acetylcholine receptor; NIC; nicotine; Pdb; protein databank; rmsd; root-mean-squared-deviation; ROC; receiver op

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Interactions of acetylcholine binding site residues contributing to nicotinic acetylcholine receptor gating: Role of residues Y93, Y190, K145 and D200

Keywords: ACh; acetylcholine; nAChR; nicotinic acetylcholine receptor; AChBP; acetylcholine binding protein; LBD; ligand binding domain; dTC; d-tubocurarine; DC6C; Dansyl C6 Choline; nAChR; Resting state; Desensitized state; αγ interface; αδ interface; Molecula

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Structure-based design, synthesis and structure–activity relationships of dibenzosuberyl- and benzoate-substituted tropines as ligands for acetylcholine-binding protein

Keywords: Fragment-merging; Structure-based design; AChBP; nAChR; Hit-optimization

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The pharmacological profile of ELIC, a prokaryotic GABA-gated receptor

Keywords: Cys-loop; Erwinia; Ligand-gated; Antagonist; Nicotinic; ELIC; GLIC; GABA; nACh; nicotinic acetylcholine; AChBP; acetylcholine binding protein; GABA; γ-aminobutyric acid; ELIC; Erwinia ligand-gated ion channel; GLIC; Gloeobacter ligand-gated ion channel;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs

Keywords: ACHBP; acetylcholine-binding protein; DMXBA; 3-(2,4-dimethoxybenzilidene)-anabaseine; HBD; hydrogen-bond donor; nAChR; nicotinic acetylcholine receptor; Pdb; protein databank; rmsd; root-mean-squared-deviation; ROC; receiver operating characteristic curve

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Identification of novel α7 nicotinic receptor ligands by in silico screening against the crystal structure of a chimeric α7 receptor ligand binding domain

Keywords: α7 Receptor; nAChR; AChBP; Virtual screening; In silico screening; Docking; Cys-loop;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

The Haemonchus contortus UNC-49B subunit possesses the residues required for GABA sensitivity in homomeric and heteromeric channels

Keywords: 5-HT3; serotonin (5-hydroxytryptamine)-gated ion channel receptor; AChBP; acetylcholine binding protein; cRNA; copy RNA; LGIC; ligand-gated ion channels; MS-222; 3-aminobenzoic acid ethyl ester, methanesulphonate salt; nAChR; nicotinic acetylcholine recep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Allosteric modulators induce distinct movements at the GABA-binding site interface of the GABA-A receptor

Keywords: GABAA receptor; Benzodiazepine efficacy; Oocyte expression; Allosteric modulation; Pentobarbital; GABA; BZD; benzodiazepine; GABAR; GABA-A receptor; MTSEA-Biotin; N-biotinaminoethyl methanethiosulfonate; MTSES; 2-sulfonatoethyl methanethiosulfonate; DMCM;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): Application to the design of related α7 selective ligands

Keywords: AChBPs; Nicotinic acetylcholine receptor α7; Docking; Benzylidene-anabaseine analogs; Spirodiazepine and spiroimidazoline quinuclidine series; Ac; Aplysia californica; ACHBP; Acetylcholine-binding protein; AD; Alzheimer's disease; ADHD; Attention defic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Aconitum and Delphinium alkaloids of curare-like activity. QSAR analysis and molecular docking of alkaloids into AChBP

Keywords: Alkaloids; QSAR; Molecular docking; Toxicity; Curare-like activity; nAChR-binders; AChBP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Docking to flexible nicotinic acetylcholine receptors: A validation study using the acetylcholine binding protein

Keywords: Protein flexibility; Molecular docking; Ensemble generation; Nicotinic; Acetylcholine receptors; nAChR; Acetylcholine binding protein; AChBP

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

A computational study of the binding of 3-(arylidene) anabaseines to two major brain nicotinic acetylcholine receptors and to the acetylcholine binding protein

Keywords: Nicotinic acetylcholine receptor; QSAR; AChBP; Docking; Anabaseine; DMBXA; GTS-21; Benzylidene-anabaseine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2010 سفارش ترجمه

Effect of homologous serotonin receptor loop substitutions on the heterologous expression in Pichia of a chimeric acetylcholine-binding protein with α-bungarotoxin-binding activity

Keywords: α-Bungarotoxin; AChBP; Acetylcholine-binding protein; Serotonin receptor; Cys-loop; Ligand-gated ion channels

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2009 سفارش ترجمه

Design and expression of human α7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties

Keywords: α-bgtx; α-bungarotoxin; α7-dm-ECD; double mutant of the α7-ECD; α7-wt-ECD; wild-type of the α7-ECD; ACh; acetylcholine; AChBP; acetylcholine-binding protein; BSA; bovine serum albumin; CCh; carbamylcholine; CD; circular dichroism; DLS; dynamic light

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2009 سفارش ترجمه

Docking of 6-chloropyridazin-3-yl derivatives active on nicotinic acetylcholine receptors into molluscan Acetylcholine Binding Protein (AChBP)

Keywords: Docking; 6-Chloropyridazin-3-yl derivatives; AChBP;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2005 سفارش ترجمه

Activation of ionotropic receptors and thermodynamics of binding

Keywords: AChBP; acetylcholine binding protein; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole; ΔCp; heat capacity change; ΔH; change in enthalpy; ΔS; change in entropy; ΔG; change in free energy; GABAA; A-type γ-aminobutyric acid; MPPB; 1-methyl-5-phenyl-5-pro

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2005 سفارش ترجمه

A chimera encoding the fusion of an acetylcholine-binding protein to an ion channel is stabilized in a state close to the desensitized form of ligand-gated ion channels

Keywords: AChBP; Acetylcholine; Nicotinic; Receptor; Pentameric ligand-gated ion channel; Allosteric transitions; AChBP; Acétylcholine; Nicotinique; Récepteur; Canal ionique liée à un ligand pentamère; Transitions allostériques;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2005 سفارش ترجمه

A model for short α-neurotoxin bound to nicotinic acetylcholine receptor from Torpedo californica: Comparison with long-chain α-neurotoxins and α-conotoxins

Keywords: nAChR; nicotinic acetylcholine receptors; AChBP; acetylcholine-binding protein; MD; molecular dynamics; NTII; α-neurotoxin II; Snake three-fingered short α-neurotoxin; Nicotinic acetylcholine receptor; Toxin-receptor complex; Experimental data based m

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2005 سفارش ترجمه

The role of inflammation in Alzheimer's disease

Keywords: αBTx; α-bungarotoxin; Aβ; beta-amyloid protein; ACh; acetylcholine; AChBP; acetylcholine-binding protein; AChR; nicotinic acetylcholine receptor; AD; Alzheimer's disease; AICD; amyloid precursor protein intracellular domain; AP; amyloid P; APP; amyloid

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2005 سفارش ترجمه