دانلود مقالات ISI درباره AdoMet، S-adenosyl-L-metionine + ترجمه فارسی

طراحی یک کتابخانه قطعه باعث می شود مهار کننده های قوی و انتخابی نیمه آلدئید دهیدروژناز آسپارتات

Elaboration of a fragment library hit produces potent and selective aspartate semialdehyde dehydrogenase inhibitors

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; ASA, aspartate semialdehyde; DCM, dichloromethane; FBDD, fragment-based drug discovery; HEPES, 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethane-sulfonic acid; NBS, N-bromosuccinimide; spASADH, Streptococcus pneumoniae aspartate

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Protein arginine methyltransferase 7 has a novel homodimer-like structure formed by tandem repeats

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; SAXS, small-angle X-ray scatteringProtein arginine methyltransferase; S-adenosyl-l-homocysteine; X-ray crystallography

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Yeast-based assays for the high-throughput screening of inhibitors of coronavirus RNA cap guanine-N7-methyltransferase

Keywords: AdoMet، S-adenosyl-L-metionine; SARS, severe acute respiratory syndrome; SARS-CoV, SARS coronavirus; nsp, nonstructural protein; N7-MTase, guanine-N7-methyltransferase; 2′-O-MTase, 2′-O-methyltransferase; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; ATA, aurintric

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Novel S-adenosyl-L-methionine decarboxylase inhibitors as potent antiproliferative agents against intraerythrocytic Plasmodium falciparum parasites

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; AdoMetDC, S-adenosyl-l-methionine decarboxylase; dcAdoMet, decarboxylated S-adenosyl-l-methionine; DFMO, dl-α-difluoromethylornithine; Genz-644043, 2′-fluoro-5′-{[(Z)-4-amino-2-butenyl]methylamino}-5′-deoxyadenosine; Genz-

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Development of specific dengue virus 2′-O- and N7-methyltransferase assays for antiviral drug screening

Keywords: AdoMet، S-adenosyl-L-metionine; DENV, dengue virus; NS, non-structural; MTase, methyltransferase; SLA, stem-loop A; DEAE, diethylaminoethyl; DF, dengue fever; DHF, dengue hemorrhagic fever; DSS, dengue shock syndrome; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; S

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

MS3 fragmentation patterns of monomethylarginine species and the quantification of all methylarginine species in yeast using MRM3

Keywords: AdoMet، S-adenosyl-L-metionine; aDMA, asymmetric Nη1,Nη1-dimethylarginine; AdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; [methyl-CD3] AdoMet, S-adenosyl-l-[methyl-CD3]-methionine; CID, collision-induced dissociation; CPM, counts per min; HPLC, high performance liqu

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Beneficial effects of natural phenolics on levodopa methylation and oxidative neurodegeneration

Keywords: AdoMet، S-adenosyl-L-metionine; L-DOPA, levodopa; PD, Parkinson disease; COMT, catechol-O-methyltransferase; 3-OMD, 3-O-methyldopa; CNS, central nervous system; H2-DCF-DA, 2′,7′-dichlorofluorescein diacetate; AdoMet, S-adenosyl-L-methionine; ROS, reactive oxygen species; MTT, 3-(4,5-dim

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Biotin synthase: Insights into radical-mediated carbon–sulfur bond formation

Keywords: AdoMet، S-adenosyl-L-metionine; ACP, acyl carrier protein; AdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; AON, 8-amino-7-oxononanoate; CoA, coenzyme A; DAPA, 7,8-diaminopelargonic acid; DAPA, 7,8-diaminopelargonic acid; DTB, dethiobiotin or 5-methyl-2-oxo-4-imidazol

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; DTT, dithiothreitol; IPTG, isopropyl-β-d-thiogalactoside; MTase, methyltransferase; SAXS, small-angle X-ray scatteringrRNA methyltransferase; Dimeric conformation; AdoMet binding domain; Cytidine recognition domain; Small-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Pyridoxal-5′-phosphate-dependent enzymes involved in biotin biosynthesis: Structure, reaction mechanism and inhibition

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-L-methionine; ALAS, 5-aminolevulinate synthase, EC 2.3.1.37; AON, 8-amino-7-oxononanoic acid (KAPA was also used in the older literature); AONS, 8-amino-7-oxononanoate synthase (KAPA synthase), EC 2.3.1.47; DAPA, 7,8-diaminononanoic aci

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Adding a Lysine Mimic in the Design of Potent Inhibitors of Histone Lysine Methyltransferases

Keywords: AdoMet، S-adenosyl-L-metionine; GLP, G9a-like protein; H3K9, histone H3 lysine 9; AdoHcy, S-adenosyl-l-homocysteine; DMSO, dimethyl sulfoxide; AdoMet, S-adenosyl-l-methionine; PDB, Protein Data Bankepigenetics; histone lysine methylation; enzymatic inhibition; lysine mimics

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

PRMT3 is essential for dendritic spine maturation in rat hippocampal neurons

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-L-methionine; αCaMKII, α subunit of the calcium/calmodulin-dependent protein kinase II; BDNF, brain-derived neurotrophic factor; CARM1, coactivator-associated arginine methyltransferase 1; NGF, nerve growth factor; PRMT, protein arginin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2010 سفارش ترجمه

Mechanism of DNA Methylation: The Double Role of DNA as a Substrate and as a Cofactor

Keywords: AdoMet، S-adenosyl-L-metionine; DMT, DNA methyltransferase; AdoMet, S-adenosyl-l-methionine; TS, thymidylate synthase; M.HhaI, HhaI methyltransferase; dUMP, 2′-deoxyuridine 5′-monophosphateDNA cytosine methyltransferase; methylation reaction mechanism; DNA as cofactor; DNA phosphate gro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2010 سفارش ترجمه

Crystal structure of a methyltransferase from a no-known-vector Flavivirus

Keywords: AdoMet، S-adenosyl-L-metionine; TBFVs, tick-borne flaviviruses; MBFVs, mosquito-borne flaviviruses; NKVs, flaviviruses with no known vector; NS, non-structural protein; MTase, methyltransferase; RdRp, RNA-dependent-RNA polymerase; AdoMet, S-adenosyl-l-methionine; Yv, Yokose virus; Dv, D

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Flaviviral methyltransferase/RNA interaction: Structural basis for enzyme inhibition

Keywords: AdoMet، S-adenosyl-L-metionine; RdRp, RNA dependent RNA polymerase; N7 MTase, guanine N7 methyltransferase; 2′O MTase, nucleoside-2′O methyltransferase; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; Wv, Wesselsbron virus; NS, non-structural protein; GMP, guanosine

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2009 سفارش ترجمه

Valproic acid enhances protein l-isoaspartyl methyltransferase expression by stimulating extracellular signal-regulated kinase signaling pathway

Keywords: AdoMet، S-adenosyl-L-metionine; Protein l-isoaspartyl methyltransferase; Valproic acid; Epilepsy; ERK1/2 signaling pathway; RSK-1; GSK-3; β-cateninAdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; CBZ, carbamazepine; DMSO, dimethyl sulfoxide; DSIP-isoD, Delta-sleep-ind

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2009 سفارش ترجمه

Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus

Keywords: AdoMet، S-adenosyl-L-metionine; NS, nonstructural proteins; RTPase, RNA triphosphatase; GMP, guanosine monophosphate; GTase, guanylyltransferase; N7-MTase, guanine N7-methyltransferase; AdoMet, S-adenosyl-l-methionine; MVEvMTase, Murray Valley encephalitis virus MTase; DvMTase, dengue v

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2009 سفارش ترجمه

Identification of inhibitors of the E. coli cyclopropane fatty acid synthase from the screening of a chemical library: In vitro and in vivo studies

Keywords: AdoMet، S-adenosyl-L-metionine; AdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; CFAS, cyclopropane fatty acid synthase; CMAS, cyclopropane mycolic acid synthases; DMSO, dimethylsulfoxide; DTNB, 5,5′-dithiobis-2-nitrobenzoic acid; FAME, fatty acid methyl ester; HTS, h

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2008 سفارش ترجمه

Production of yeast tRNA (m7G46) methyltransferase (Trm8–Trm82 complex) in a wheat germ cell-free translation system

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; PAGE, polyacrylamide gel electrophoresisRNA modification; tRNA methyltransferase; 7-Methylguanine; Trm8–Trm82; Cell-free protein synthesis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

A scintillation proximity assay for dengue virus NS5 2′-O-methyltransferase—kinetic and inhibition analyses

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; DENV, dengue virus; DENV2, dengue virus type 2; DF/DHF, dengue fever/dengue hemorrhagic fever; DTT, dithiothreitol; DNMT, DNA methyltransferase; IC50, inhibitory concentration that causes 50% reduction in enzyme activity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Crystal Structure and Mutational Study of a Unique SpoU Family Archaeal Methylase that Forms 2′-O-Methylcytidine at Position 56 of tRNA

Keywords: AdoMet، S-adenosyl-L-metionine; SeMet, selenomethionine; AdoMet, S-adenosyl-L-methionine; MAD, multi-wavelength anomalous dispersion; aTrm56, archaeal tRNA-methylase for position 56; ArcTGT, archaeosine tRNA-guanine transglycosylase; Cm56, 2′-O-methylcytidine residue at position 56aTrm5

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Mouse Dnmt3a Preferentially Methylates Linker DNA and Is Inhibited by Histone H1

Keywords: AdoMet، S-adenosyl-L-metionine; Dnmt, DNA methyltransferase; AdoMet, S-adenosyl-l-methionine; GD, globular domain; MNase, micrococcal nucleaseDNA methyltransferase; Dnmt3a; dinucleosomes; histone H1

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Crystal Structure of tRNA N2,N2-Guanosine Dimethyltransferase Trm1 from Pyrococcus horikoshii

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; Trm1, tRNA m22G dimethyltransferase; m2G, N2-monomethylguanosine; m22G, N2,N2-dimethylguanosine; MTase, methyltransferase; PDB, Protein Data Bank; MAD, multiple-wavelength anomalous diffr

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Crystal Structure of the Escherichia coli 23S rRNA:m5C Methyltransferase RlmI (YccW) Reveals Evolutionary Links between RNA Modification Enzymes

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; MTase, methyltransferase; RFM, Rossmann-fold methyltransferases; m5C, 5-methylcytosine; SelMet, l-selenomethionine; AUC, analytical ultracentrifugation; PDB, Protein Data Bank; r-protein, ribosomal protein; AdoHcy, S-adeno

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

6His–Eco29kI methyltransferase methylation site and kinetic mechanism characterization

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; RMS, restriction–modification system; MTase, DNA-methyltransferase; RE, restriction endonuclease; 6His, 6 Histidine residues; LB medium, Luria–Bertani medium; Rpm, rotations per minute; DE, diethylaminoethyl; Ni-NTA, Nicke

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Structural and Functional Analysis of Methylation and 5′-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5

Keywords: AdoMet، S-adenosyl-L-metionine; DV, dengue virus; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; RTPase, RNA triphosphatase; GTase, guanylyltransferase; 2′OMTase, nucleoside-2′-O-methyltransferase; N7MTase, guanine-N7-methyltransferase; NS, non-structural proteinmet

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2007 سفارش ترجمه

Stabilisation of a (βα)8-Barrel Protein Designed from Identical Half Barrels

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-L-methionine; CAT, chloramphenicol acetyltransferase; MD, molecular dynamics; GdmCl, guanidinium chlorideprotein design; enzyme evolution; (βα)8-barrel; half barrel; stability screen

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2007 سفارش ترجمه

Identification of new inhibitors of E. coli cyclopropane fatty acid synthase using a colorimetric assay

Keywords: AdoMet، S-adenosyl-L-metionine; AdoHcy, S-adenosyl-l-homocysteine; AdoMet, S-adenosyl-l-methionine; BSA, bovin serum albumin; CFAS, cyclopropane fatty acid synthase; CMAS, cyclopropane mycolic acid synthases; DMF, N,N-dimethylformamide; DMSO, dimethylsulfoxyde; DTNB, 5,5′-dithiobis-2-ni

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Sequential O-methylation of tricetin by a single gene product in wheat

Keywords: AdoMet، S-adenosyl-L-metionine; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; COMT, caffeic acid O-methyltransferase; 5HF, 5-hydroxyferulic acid; HPLC, high performance liquid chromatography; MS, mass spectrometry; OMT, O-methyltransferase; ORF, open reading frame;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2006 سفارش ترجمه

The Role of Arg165 Towards Base Flipping, Base Stabilization and Catalysis in M.HhaI

Keywords: AdoMet، S-adenosyl-L-metionine; WT, wild-type; M.HhaI, HhaI DNA methyltransferase; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; 2AP, 2-aminopurine; MD, molecular dynamicsmethyltransferase; kinetics; base flipping; cocrytal structure; sugar pucker

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Structure and Substrate Recognition of the Escherichia coli DNA Adenine Methyltransferase

Keywords: AdoMet، S-adenosyl-L-metionine; Dam methylation; GATC recognition; base flipping; bacterial virulence factorMTase, methyltransferase; AdoMet, S-adenosyl-l-methionine; AdoHcy, S-adenosyl-l-homocysteine; EcoDam, E. coli DNA adenine MTase

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه

Catalytic mechanism of S-adenosylhomocysteine hydrolase: Roles of His 54, Asp130, Glu155, Lys185, and Aspl89

Keywords: AdoMet، S-adenosyl-L-metionine; Ado, adenosine; Ado*, 3′-keto-adenosine; AdoHcy, S-adenosyl-l-homocysteine; AdoHcyase, S-adenosyl-l-homocysteine hydrolase; AdoMet, S-adenosyl-l-methionine; D244E:(NADH + Ado*), rat liver D244E mutated enzyme complexed with NADH and Ado*; DEA, d-eritadeni

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2005 سفارش ترجمه