Keywords: آجرکیناز; Aggrecanase; articular cartilage; diagnosis; hand; knee; mechanical injury; MRCP; osteoarthritis; tests; treatment;
مقالات ISI آجرکیناز (ترجمه نشده)
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Keywords: آجرکیناز; Aggrecanase; articular cartilage; mechanical injury; osteoarthritis
Keywords: آجرکیناز; Atomic force microscopy; Type VI collagen; Aggrecanase; Chondroitin sulfate; Chondron; Perlecan; Hyaluronic acid;
Anti-arthritic actions of β-cryptoxanthin against the degradation of articular cartilage in vivo and in vitro
Keywords: آجرکیناز; Rheumatoid arthritis; Osteoarthritis; Carotenoid; Extracellular matrix; Aggrecanase; Chondrocytes;
Development of human neutralizing antibody to ADAMTS4 (aggrecanase-1) and ADAMTS5 (aggrecanase-2)
Keywords: آجرکیناز; ADAMTS4; ADAMTS5; Aggrecanase; Human antibody; Cartilage; Osteoarthritis;
Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
Keywords: آجرکیناز; ADAMTS; ADAMTS-like; Metalloproteinase; Extracellular matrix; Mouse; Knockout; Forward genetics; Reverse genetics; Procollagen; Aggrecanase;
An ARGS-aggrecan assay for analysis in blood and synovial fluid
Keywords: آجرکیناز; Osteoarthritis; Aggrecan; Aggrecanase; Biomarkers; Blood; Synovial fluid;
ADAMTS1, ADAMTS5, ADAMTS9 and aggrecanase-generated proteoglycan fragments are induced following spinal cord injury in mouse
Keywords: آجرکیناز; ADAMTS; Aggrecanase; Spinal cord injury; Astrocytes;
Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes
Keywords: آجرکیناز; Chondrocyte; Mechanical stress; RUNX-2; Aggrecanase; ADAMTS; Histone deacetylase inhibitor
Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group
Keywords: آجرکیناز; Acylthiosemicarbazide; Aggrecanase; Library
Association of serum levels of aggrecan ARGS, NITEGE fragments and radiologic knee osteoarthritis in Tunisian patients
Keywords: آجرکیناز; Osteoarthritis; Aggrecan; Aggrecanase; Cartilage; Biomarkers
The association between changes in synovial fluid levels of ARGS-aggrecan fragments, progression of radiographic osteoarthritis and self-reported outcomes: a cohort study
Keywords: آجرکیناز; Osteoarthritis; Aggrecan; Aggrecanase; Biomarkers; Meniscus injury; Patient-reported Outcome
Proteases involved in cartilage matrix degradation in osteoarthritis
Keywords: آجرکیناز; ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APC; activated protein C; CITED2; cAMP-responsive element-binding protein/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; ECM; extracellular matrix; ERK;
Structure–activity study on a series of α-glutamic acid scaffold based compounds as new ADAMTS inhibitors
Keywords: آجرکیناز; Osteoarthritis; Aggrecanase; ADAMTS; Glutamic acid scaffold
Orally active achiral N-hydroxyformamide inhibitors of ADAM-TS4 (aggrecanase-1) and ADAM-TS5 (aggrecanase-2) for the treatment of osteoarthritis
Keywords: آجرکیناز; ADAM-TS4; ADAM-TS5; Aggrecanase; Reverse hydroxamate; Osteoarthritis
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor
Keywords: آجرکیناز; Aggrecan; Aggrecanase; Joint injury; Synovial fluid; Osteoarthritis;
Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells
Keywords: آجرکیناز; Chondrocyte; Mechanical stress; RUNX-2; ADAMTS; Aggrecanase
Human aggrecanase generated synovial fluid fragment levels are elevated directly after knee injuries due to proteolysis both in the inter globular and chondroitin sulfate domains
Keywords: آجرکیناز; Aggrecan; Aggrecanase; Biomarker; Degradation; Synovial fluid; Western blot
Osteoarthritis
Keywords: آجرکیناز; aggrecanase; articular cartilage; mechanical injury; osteoarthritis
Identifying the human aggrecanase
Keywords: آجرکیناز; Aggrecan; Aggrecanase; Cartilage; ADAMTS-4; ADAMTS-5; Messenger RNA; Proteinase activity
10 mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin
Keywords: آجرکیناز; Aggrecanase; Glucosamine; ADAMTS; Furin; Catabolism
Dynamic loading enhances integrative meniscal repair in the presence of interleukin-1
Keywords: آجرکیناز; Meniscus; Tissue repair; Mechanical loading; Bioreactor; Matrix metalloproteinase; Aggrecanase; Nitric oxide
Development of a novel clinical biomarker assay to detect and quantify aggrecanase-generated aggrecan fragments in human synovial fluid, serum and urine
Keywords: آجرکیناز; Aggrecanase; Aggrecan; Neoepitope antibody; ARGS; Hyaluronic-acid binding region (HABR); Biomarker; Sandwich ELISA
MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation
Keywords: آجرکیناز; Articular cartilage; Cartilage degradation; Catabolic enzymes; Cell signaling pathways; Matrixmetalloprotinase; Aggrecanase; Osteoarthritis; Cartilage metabolism; Enzyme pathways; Mitogen-activated protein kinases (MAPKs)
An immunoaffinity liquid chromatography–tandem mass spectrometry assay for detection of endogenous aggrecan fragments in biological fluids: Use as a biomarker for aggrecanase activity and cartilage degradation
Keywords: آجرکیناز; Aggrecan; Aggrecanase; Biomarker; Osteoarthritis; Immunoaffinity; LC–MS/MS; Antibody capture; SISCAPA; Peptide quantitation
The C-terminal domains of ADAMTS-4 and ADAMTS-5 promote association with N-TIMP-3
Keywords: آجرکیناز; ADAM; adamalysin; ADAMTS; adamalysin with thrombospondin motifs; cat; catalytic domain; CysR; cysteine-rich; Dis; disintegrin; LRP; low-density lipoprotein receptor-related protein; MMP; matrix metalloproteinase; N-TIMP; N-terminal domain of TIMP; RAP; re
Intra-articular injection of tumor necrosis factor-α in the rat: an acute and reversible in vivo model of cartilage proteoglycan degradation
Keywords: آجرکیناز; Aggrecanase; ADAMTS; Aggrecan; Cartilage; Animal model; Neoepitope
Co-culture of mechanically injured cartilage with joint capsule tissue alters chondrocyte expression patterns and increases ADAMTS5 production
Keywords: آجرکیناز; Cartilage injury; Joint capsule; Synovium; Aggrecan; Aggrecanase; Chondrocyte gene profiling; ADAMTS4; ADAMTS5; Matrix degradation; Cartilage
Western blot quantification of aggrecan fragments in human synovial fluid indicates differences in fragment patterns between joint diseases
Keywords: آجرکیناز; Aggrecan; Aggrecanase; Proteolytic fragments; Synovial fluid; Western blot
Nobiletin, a citrus polymethoxy flavonoid, suppresses gene expression and production of aggrecanases-1 and -2 in collagen-induced arthritic mice
Keywords: آجرکیناز; ADAMTS; a disintegrin and metalloproteinase with thrombospondin-like motifs; CIA; collagen-induced arthritis; COX; cyclooxygenase; FBS; fetal bovine serum; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; IGD; interglobular domain; IL; interleukin; MEK;
Calcium pentosan polysulfate directly inhibits enzymatic activity of ADAMTS4 (aggrecanase-1) in osteoarthritic chondrocytes
Keywords: آجرکیناز; Osteoarthritis; ADAMTS4; Aggrecanase; Calcium pentosan polysulfate; Inhibition; Cartilage; Destruction
Mechanism of proteoglycan aggregate degradation in cartilage stimulated with oncostatin M
Keywords: آجرکیناز; Aggrecanase; ADAMTS; MMP; Hyaluronidase; IL-1; TNFα
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
Keywords: آجرکیناز; Aggrecanase; High-throughput screening; FRET substrate; Aggrecanase inhibitor; Osteoarthritis
Articular cartilage metabolism in patients with Kashin–Beck Disease: an endemic osteoarthropathy in China
Keywords: آجرکیناز; Kashin–Beck Disease; CD44; Aggrecanase; Aggrecan metabolism; IL-1β; TNF-α; Osteoarthritis; Proteoglycan; Osteoarthropathy
Nitric oxide enhances aggrecan degradation by aggrecanase in response to TNF-α but not IL-1β treatment at a post-transcriptional level in bovine cartilage explants 1
Keywords: آجرکیناز; Tumor necrosis factor alpha; Nitric oxide; Interleukin 1; Matrix degradation; Aggrecan; Aggrecanase
Proprotein convertase activation of aggrecanases in cartilage in situ
Keywords: آجرکیناز; Aggrecanase; ADAMTS; PACE4; Proprotein convertase; Cartilage; Osteoarthritis; Metalloproteases; Post-translational activation
Synthesis and evaluation of aryl thioxothiazolidinone inhibitors of ADAMTS-5 (Aggrecanase-2)
Keywords: آجرکیناز; Aggrecanase; ADAMTS-5; Thioxothiazolidinone; Metalloprotease inhibitor; Zinc chelator
Selective and non-selective metalloproteinase inhibitors reduce IL-1-induced cartilage degradation and loss of mechanical properties
Keywords: آجرکیناز; Cartilage; Degradation; Mechanical properties; Interleukin-1; Aggrecanase; MMP
Aggrecanolysis in human osteoarthritis: confocal localization and biochemical characterization of ADAMTS5–hyaluronan complexes in articular cartilages
Keywords: آجرکیناز; Aggrecanase; Osteoarthritis; ADAMTS5; Cartilage; Hyaluronan; Confocal microscopy; Immunohistochemistry
A microplate assay for the screening of ADAMTS-4 inhibitors
Keywords: آجرکیناز; Aggrecanase; Screening assay; ADAMTS-4; Proteoglycan degradation; Anti-ARGSV antibody; HPCE
Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: Comparative analyses with ADAMTS-5, -9, -16 and -18
Keywords: آجرکیناز; ADAMTS; Aggrecan; aggrecanase; Glycosaminoglycan-binding; Metalloproteinase; Proteoglycan
Differential regulation of matrix degrading enzymes in a TNFα-induced model of nucleus pulposus tissue degeneration
Keywords: آجرکیناز; Intervertebral disc; Nucleus pulposus; Matrix metalloproteinase; Aggrecanase; MAPK; NF-κB
High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis
Keywords: آجرکیناز; Hyaluronic acid; Osteoarthritis; Fibroblast-like synoviocytes; Aggrecanase; Cytokine; Enzyme
Development and characterization of a highly specific and sensitive sandwich ELISA for detection of aggrecanase-generated aggrecan fragments
Keywords: آجرکیناز; Aggrecanase; Aggrecan; Synovial fluid; Cartilage; Osteoarthritis; Biomarker
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanase- and matrix metalloproteinase-generated aggrecan fragments 1
Keywords: آجرکیناز; Osteoarthritis; Cartilage; Synovial fluid; Aggrecan; Aggrecanase; Matrix metalloproteinase
Triptolide suppresses proinflammatory cytokine-induced matrix metalloproteinase and aggrecanase-1 gene expression in chondrocytes
Keywords: آجرکیناز; Cytokines; Chondrocytes; Matrix metalloproteinases; Aggrecanase; Triptolide;
Aggrecanase-1 (ADAMTS-4) interacts with α1-antitrypsin
Keywords: آجرکیناز; Aggrecan; Aggrecanase; α1-antitrypsin; Two-hybrid;
Cytokine induced metalloproteinase expression and activity does not correlate with focal susceptibility of articular cartilage to degeneration
Keywords: آجرکیناز; Aggrecanase; Matrix metalloproteinases; Cartilage catabolism; MMP; matrix metalloproteinase; IL-1; interleukin-1; OSM; oncostatin M; GAG; glycosaminoglycan; IGD; interglobular domain of the aggrecan core protein; DMMB; dimethylmethylene blue; MAb; monoclo
ADAMTS-4 (aggrecanase-1): N-Terminal activation mechanisms
Keywords: آجرکیناز; ADAMTS-4; Aggrecanase; Aggrecan; MMP; Proprotein convertase; Activation;