کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
6125601 | 1220200 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Elevated aggrecanase activity in a rat model of joint injury is attenuated by an aggrecanase specific inhibitor
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Aggrecanase-generated aggrecan fragments were rapidly released into human and rat joint fluids after injury to the knee and remained elevated over a prolonged period. Our findings in human and preclinical models strengthen the connection between aggrecanase activity in joints and knee injury and disease. The ability of a small molecule aggrecanase inhibitor to reduce the release of aggrecanase-generated aggrecan fragments into rat joints suggests that pharmacologic inhibition of aggrecanase activity in humans may be an effective treatment for slowing cartilage degradation following joint injury.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Osteoarthritis and Cartilage - Volume 19, Issue 3, March 2011, Pages 315-323
Journal: Osteoarthritis and Cartilage - Volume 19, Issue 3, March 2011, Pages 315-323
نویسندگان
P.S. Chockalingam, W. Sun, M.A. Rivera-Bermudez, W. Zeng, D.R. Dufield, S. Larsson, L.S. Lohmander, C.R. Flannery, S.S. Glasson, K.E. Georgiadis, E.A. Morris,