The molecular chaperone heat shock protein-90 positively regulates rotavirus infection
Keywords: آکت; Rotavirus; NFκB; Akt; HSP90; 17-AAG; Geldanamycin analogs
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Search for a functional glucocorticoid receptor in the mammalian lens
Keywords: آکت; lens epithelium; glucocorticoid receptor; posterior subcapsular cataract; MAPK; AKT; MKP-1; GILZ
Gab1 transduces PI3K-mediated erythropoietin signals to the Erk pathway and regulates erythropoietin-dependent proliferation and survival of erythroid cells
Keywords: آکت; Akt; Erk; Erythropoietin; Gab1; Jak2; PI3K;
Activation of PI3K/Akt signaling has a dominant negative effect on IL-12 production by macrophages infected with Leishmania amazonensis promastigotes
Keywords: آکت; Leishmania; Parasitic-protozoan; Intracellular parasitism; Signal transduction; Cytokines; IL-12; Protein kinases; PI3K; Akt
Aldehyde Dehydrogenase 2 Ameliorates Acute Cardiac Toxicity of Ethanol : Role of Protein Phosphatase and Forkhead Transcription Factor
Keywords: آکت; ethanol; ALDH2; myocardial dysfunction; Akt; AMPK; Foxo3; protein phosphatase±dL/dt, maximal velocity of shortening/relengthening; ±dP/dt, maximal velocity of pressure development and decline; ADH, alcohol dehydrogenase; ALDH, aldehyde dehydrogenase; AMPK
Intranasal administration of IGF-1 attenuates hypoxic-ischemic brain injury in neonatal rats
Keywords: آکت; Insulin-like growth factor-1; Intranasal administration; Cerebral hypoxia-ischemia; Newborn; Akt; Proliferation
Forkhead Box, Class O Transcription Factors in Brain: Regulation and Behavioral Manifestation
Keywords: آکت; Akt; antidepressant; anxiety; depression; FoxOs; serotonin
The transcription factor Eya2 prevents pressure overload-induced adverse cardiac remodeling
Keywords: آکت; Cardiac hypertrophy; Heart failure; Eyes absent 2; Akt
The AMPA receptor positive allosteric modulator, S18986, is neuroprotective against neonatal excitotoxic and inflammatory brain damage through BDNF synthesis
Keywords: آکت; NMDA; IL-1β; ERK; Akt; Cell death
Combination of imatinib and vinorelbine enhances cell growth inhibition in breast cancer cells via PDGFR β signalling
Keywords: آکت; Imatinib mesylate; Breast cancer; PDGFR; Akt; Targeted therapy
Additive effect of apicidin and doxorubicin in sulfatase 1 expressing hepatocellular carcinoma in vitro and in vivo
Keywords: آکت; Akt; protein kinase Akt; CHAPs; cyclic-hydroxamic-acid-containing peptides; DAPI; 4,6-diamidino-2-phenylidole dihydrochloride; Erk; extracellular signal-regulated kinase; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; MAPK; mitogen activated pr
The role of Akt/protein kinase B subtypes in retinal ischemic preconditioning
Keywords: آکت; Akt; electroretinography; ischemic preconditioning; protein kinase B; retinal ischemia;
Regenerative pharmacology in the treatment of genetic diseases: The paradigm of muscular dystrophy
Keywords: آکت; MD; muscular dystrophies; DMD; duchenne muscular dystrophy; DAPC; dystrophin-associated protein complex; DGC; dystrophin-glycoprotein complex; DG; dystroglycans; SCG; sarcoglycans; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; HDAC; histone deac
Neurotrophic factors and structural plasticity in addiction
Keywords: آکت; Growth factors; Drug addiction; Dendritic spines; Brain derived neurotrophic factor; Nerve growth factor; Intracellular signaling; Neurotrophic factors; Morphine; Cocaine; Reward; Relapse; Actin polymerization; Neuron Morphology; ERK; Akt; PI3 kinase; NF
Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs/Akt-mediated cell survival pathway
Keywords: آکت; TRAIL; DNA-PKcs; Death receptors; Akt; Apoptosis; DMNB
CCL5 increases lung cancer migration via PI3K, Akt and NF-κB pathways
Keywords: آکت; ECM, extracellular matrix; PI3K, phosphatidylinositol 3-kinase; IKK α/β, IκB kinase α/β; NF-κB, nuclear factor-κBCCL5; Lung cancer; Migration; Akt; PI3K
Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium
Keywords: آکت; Chromium; Hexavalent; Particulate; Carcinogenesis; Lung; Inflammation; Injury; Akt; Intranasal; Mouse model
Insulin-stimulated translocation of GLUT4 to the plasma membrane in rat hippocampus is PI3-kinase dependent
Keywords: آکت; Glucose; Akt; Cognition; Diabetes; Confocal microscopy
Colitis induces calcitonin gene-related peptide expression and Akt activation in rat primary afferent pathways
Keywords: آکت; Colitis; CGRP; Akt; DRG; Spinal cord
Involvement of the PI3K/AKT pathway in the hypoglycemic effects of saponins from Helicteres isora
Keywords: آکت; AKT; C2C12 myotubes; Glut4 translocation; GSK-3α/β; Helicteres isora; PI3K
Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus
Keywords: آکت; Western; HSP27; MAP kinase; Akt; MKP1; p38; Exercise; Post-synaptic protein
Secreted phospholipases A2: A proinflammatory connection between macrophages and mast cells in the human lung
Keywords: آکت; AA; arachidonic acid; Akt; protein kinase B; BA; bronchial asthma; BAL; bronchoalveolar lavage; BBMCs; bone marrow-derived mast cells; COPD; chronic obstructive pulmonary disease; ERK1/2; extracellular-regulated kinase 1/2; HSPG; heparan sulfate proteogly
Neuromedin B induces angiogenesis via activation of ERK and Akt in endothelial cells
Keywords: آکت; Neuromedin B (NMB); Angiogenesis; Vascular endothelial cells; Extracellular signal-regulated kinase 1/2 (ERK1/2); Akt; Endothelial nitric oxide synthase (eNOS);
A novel Drosophila Girdin-like protein is involved in Akt pathway control of cell size
Keywords: آکت; Drosophila; Girdin; Akt; Cell size control;
Cortical deficiency of laminin γ1 impairs the AKT/GSK-3β signaling pathway and leads to defects in neurite outgrowth and neuronal migration
Keywords: آکت; Neuronal migration; Cortical development; Laminin; Neurite growth; Paxillin; FAK; AKT; GSK-3β;
Inhibition of superoxide anion generation by CHS-111 via blockade of the p21-activated kinase, protein kinase B/Akt and protein kinase C signaling pathways in rat neutrophils
Keywords: آکت; Neutrophil; Superoxide anion; p21-Activated kinase; Akt; Protein kinase C; p47phox
The nuclear localization of 3'-phosphoinositide-dependent kinase-1 is dependent on its association with the protein tyrosine phosphatase SHP-1
Keywords: آکت; Phospholipid; PDK1; Akt; Src kinase; Nuclear localization; SHP-1/PTP1C;
Reciprocal regulation of the ubiquitin ligase Itch and the epidermal growth factor receptor signaling
Keywords: آکت; EGF, Epidermal growth factor; JNK, c-Jun N-terminal kinase; HECT, homologous to E6Ap C-terminusCbl; Endophilin; c-Jun N-terminal kinase; Akt; Ubiquitin; FAM; Usp9x
Potentiation of paclitaxel-induced apoptosis by galectin-13 overexpression via activation of Ask-1-p38-MAP kinase and JNK/SAPK pathways and suppression of Akt and ERK1/2 activation in U-937 human macrophage cells
Keywords: آکت; Apoptosis; Cytoprotection; Galectin-13; MAPK; Ask-1; Akt; AIF; JNK; ERK; Taxol
Non-redundant roles of the Gab1 and Gab2 scaffolding adapters in VEGF-mediated signalling, migration, and survival of endothelial cells
Keywords: آکت; Akt; Endothelial cells; Gab1; Gab2; Migration; Survival; VEGF
Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols
Keywords: آکت; AIF; apoptosis inducing factor; Akt; protein kinase B; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; HBSS; Hank's buffered salt solution; MAP kinase; mitogen-activated protein kinase; NF-κB; nuclear factor-κB; ROS; reactive oxygen species; SOD; sup
Tubulin acetylation favors Hsp90 recruitment to microtubules and stimulates the signaling function of the Hsp90 clients Akt/PKB and p53
Keywords: آکت; Hsp90; Microtubule; Acetylation; Akt; p53;
Netrin-4 regulates angiogenic responses and tumor cell growth
Keywords: آکت; HMVECs, human microvascular endothelial cells; Ntn-4, Netrin-4Netrin-4; Angiogenesis; Tumor cells; Jnk; Akt; Phosphorylation
Prognostic significance of Akt, phospho-Akt and BAD expression in primary breast cancer
Keywords: آکت; Akt; Phospho-Akt; BAD; Immunohistochemistry; Breast cancer
Pretreatment with a single estradiol-17β bolus activates cyclic-AMP response element binding protein and protects CA1 neurons against global cerebral ischemia
Keywords: آکت; in vivo; signal transduction; cerebral blood flow; neuroprotection; cyclic-AMP response element binding protein; hormone replacement therapy; Akt; protein kinase B; Bcl-2; B-cell leukemia/lymphoma 2; CaMKII; calcium-calmodulin-dependent protein kinase;
The novel orally bioavailable inhibitor of phosphoinositol-3-kinase and mammalian target of rapamycin, NVP-BEZ235, inhibits growth and proliferation in multiple myeloma
Keywords: آکت; Multiple myeloma; NVP-BEZ235; PI3 kinase; Akt; mTOR
Akt1 silencing efficiencies in lung cancer cells by sh/si/ssiRNA transfection using a reductable polyspermine carrier
Keywords: آکت; Spermine; siRNA delivery; Reductable carrier; Gene delivery; Akt; siRNA comparison
Neuroprotection by c-Jun NH2-terminal kinase inhibitor SP600125 against potassium deprivation–induced apoptosis involves the Akt pathway and inhibition of cell cycle reentry
Keywords: آکت; SP600125; c-Jun NH2-terminal kinase; Akt; cell cycle; cerebellar granule cellscdk5/p35, cyclin-dependent kinase 5; CGN, cerebellar granule cell; CREB, cyclic AMP response element-binding protein; ct, cycle threshold; FOXO, Forkhead protein; GSK-3β, glycog
A critical role for AKT activation in protecting cells from ionizing radiation-induced apoptosis and the regulation of acinus gene expression
Keywords: آکت; AKT; Ionizing radiation; Apoptosis; Acinus; NF-κB; Gene expression
Akt regulates vitamin D3-induced leukemia cell functional differentiation via Raf/MEK/ERK MAPK signaling
Keywords: آکت; Vitamin D3; Leukemia; Differentiation; Akt; MAPK; Signaling
Increases in nuclear p65 activation in dystrophic skeletal muscle are secondary to increases in the cellular expression of p65 and are not solely produced by increases in IκB-α kinase activity
Keywords: آکت; Duchenne muscular dystrophy; Becker muscular dystrophy; mdx mouse; NF-κB; Diaphragm; Respiratory musculature; Limb musculature; Akt; Cell signaling
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation
Keywords: آکت; TRAIL; SAHA; HCC cells; DR5; NF-kB; Akt
Neural phosphoproteomics of a chronic hypoxia model-Lymnaea stagnalis
Keywords: آکت; proteomics; phosphorylation; hypoxia tolerance; Pro-Q Diamond; electrophysiology; behavior; Akt; protein kinase B; AP; action potential; APD50; action potential duration measured as the time from the overshoot to 50% repolarization to resting potential; C
Mitochondrial kinases in cell signaling: Facts and perspectives
Keywords: آکت; Mitochondria; MAPK; ERK1/2; Akt; Hydrogen peroxide; Proliferation; Apoptosis; Cancer
Neuroprotective actions of sex steroids in Parkinson’s disease
Keywords: آکت; Estrogen; Progesterone; Androgens; Neuroprotection; Sex difference; Parkinson’s disease; Akt; MAPK/ERK; MPTP; Methamphetamine
Mechanisms of allergy and clinical immunologySelective deregulation in chemokine signaling pathways of CD4+CD25hiCD127lo/â regulatory T cells in human allergic asthma
Keywords: آکت; Allergic asthma; regulatory T cells; cell trafficking; cell signaling; CCL1; CCR8; AKT; AA; Allergic asthmatic; AKT; Protein kinase B; BALF; Bronchoalveolar lavage fluid; ERK1/2; Extracellular signal-regulated kinase 1/2; HC; Healthy control; NA; Nonaller
Expression of Signaling Mediators Downstream of EGF-Receptor Predict Sensitivity to Small Molecule Inhibitors Directed Against the EGF-Receptor Pathway
Keywords: آکت; EGFR; KRAS; PTEN; AKT; gefitinib; SH-6
TRAF6-mediated regulation of the PI3 kinase (PI3K)–Akt–GSK3β cascade is required for TNF-induced cell survival
Keywords: آکت; TNF; TRAF6; Cell survival; PI3 kinase; Akt; GSK3β
Up-regulation of IAPs by PI-3K: A cell survival signal-mediated anti-apoptotic mechanism
Keywords: آکت; TRAIL; IAP; PI-3K; Akt; PTEN; LNCaP cells; Caspase-3; Apoptosis; Cell survival signal
The design and synthesis of potent and cell-active allosteric dual Akt 1 and 2 inhibitors devoid of hERG activity
Keywords: آکت; hERG; Allosteric; Akt; Kinase