Okadaic acid promotes angiogenesis via activation of hypoxia-inducible factor-1
Keywords: آکت; Okadaic acid; Angiogenesis; HIF-1α; Akt
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Chitosan-graft-polyethylenimine for Akt1 siRNA delivery to lung cancer cells
Keywords: آکت; Polymeric carrier; Non-viral vector; SiRNA delivery; Akt; Chitosan; Polyethylenimine; Lung cancer
Calcium alters monoamine oxidase-A parameters in human cerebellar and rat glial C6 cell extracts: Possible influence by distinct signalling pathways
Keywords: آکت; Monoamine oxidase; Calcium; Contact inhibition; Alzheimer's disease; Cancer; Post-translational modification; p38 MAP kinase; p42/44; Akt
Bleomycin-induced nuclear factor-κB activation in human bronchial epithelial cells involves the phosphorylation of glycogen synthase kinase 3β
Keywords: آکت; Akt, protein kinase B, PKB; BECs, bronchial epithelial cells; BLM, bleomycin; GSK3β, glycogen synthase kinase 3β; IκB, inhibitor of NF-κB; NF-κB, nuclear factor-κB; PI3K, phosphatidylinositol 3-kinaseBleomycin; Akt; GSK3β; NF-κB; Bronchial epithelial cell
Anti-apoptotic role of omega-3-fatty acids in developing brain: perinatal hypothyroid rat cerebellum as apoptotic model
Keywords: آکت; Caspase; Bax; Bcl-2; Bcl-xL; JNK; AKT; ERK
Mycobacterium bovis Bacillus Calmette-Guérin (BCG)-induced activation of PI3K/Akt and NF-kB signaling pathways regulates expression of CXCL10 in epithelial cells
Keywords: آکت; Akt; CXCL10; Mycobacterium bovis; NF-kB; PI3K
Rapamycin enhances LPS induction of tissue factor and tumor necrosis factor-α expression in macrophages by reducing IL-10 expression
Keywords: آکت; Tissue factor; Lipopolysaccharide; Interleukin-10; Akt; Mammalian target of rapamycin
The PI3-K/AKT-Pathway and Radiation Resistance Mechanisms in Non-small Cell Lung Cancer
Keywords: آکت; Non-small cell lung cancer; Radiotherapy; PI3-K; AKT; EGFR
Overexpression of ErbB2 induces invasion of MCF10A human breast epithelial cells via MMP-9
Keywords: آکت; ErbB2; Breast cells; MMP-9; p38 MAPK; Akt
Thiazolidinediones Downregulate Wnt/β-Catenin Signaling Via Multiple Mechanisms in Breast Cancer Cells
Keywords: آکت; PPARγ; thiazolidinedione; troglitazone; breast cancer; Wnt; β-catenin; TCF4; frizzled-1; LRP6; Akt
Upregulated expression of periostin by hypoxia in non-small-cell lung cancer cells promotes cell survival via the Akt/PKB pathway
Keywords: آکت; Periostin; Hypoxia; Apoptosis; Cell survival; Akt
PI-3-K and AKT: Onto the mitochondria
Keywords: آکت; PI-3-K; AKT; Mitochondria; Bcl-2; Hexokinase; VDAC
Restoration of SOCS3 suppresses human lung adenocarcinoma cell growth by downregulating activation of Erk1/2, Akt apart from STAT3
Keywords: آکت; SOCS; Lung carcinoma; Erk1/2; STAT3; Akt;
Propofol protects against hydrogen peroxide-induced injury in cardiac H9c2 cells via Akt activation and Bcl-2 up-regulation
Keywords: آکت; Propofol; Oxidative stress; H9c2 cells; Akt; Bcl-2; Apoptosis;
Cardioprotective stimuli mediate phosphoinositide 3-kinase and phosphoinositide dependent kinase 1 nuclear accumulation in cardiomyocytes
Keywords: آکت; Nucleus; PI3K; PDK1; Cardiomyocyte; Akt; Phosphoinositide;
Estrogen partially down-regulates PTEN to prevent apoptosis in VSC4.1 motoneurons following exposure to IFN-γ
Keywords: آکت; Akt; Caspase; Estrogen; IFN-γ; Motoneurons; PTEN
The 15-Deoxy-Î12,14-prostaglandin J2 inhibits LPS-stimulated AKT and NF-κB activation and suppresses interleukin-6 in osteoblast-like cells MC3T3E-1
Keywords: آکت; Periodontitis; 15-deoxy-Î12,14-prostaglandin J2; Interleukin-6; Osteoblast-like cells MC3T3E-1; Akt;
Ethanolic Hwaeumjeon induces mitochondrial dependent apoptosis partly via PI3K/AKT/HSP27/ERK pathways and inhibits PSA and AR in LNCaP cells
Keywords: آکت; Hwaeumjeon; PI3K; AKT; ERK; HSP27; Apoptosis; LNCaP
Gambogic acid induces G0/G1 arrest and apoptosis involving inhibition of SRC-3 and inactivation of Akt pathway in K562 leukemia cells
Keywords: آکت; Gambogic acid; SRC-3; Akt; Apoptosis; Leukemia
Apoptosis of metastatic prostate cancer cells by a combination of cyclin-dependent kinase and AKT inhibitors
Keywords: آکت; Prostate cancer; Roscovitine; AKT; cdk9; PC3;
Response gene to complement 32 is required for C5b-9 induced cell cycle activation in endothelial cells
Keywords: آکت; RGC-32; C5b-9; Complement activation; Endothelial cells; Akt
Soy phytoestrogens are neuroprotective against stroke-like injury in vitro
Keywords: آکت; AKT; Akt serine-threonine kinase; BSA; bovine serum albumin; B27; B-27 serum-free supplement; Calcein AM; calcein acetoxymethylester; DAPI; 4â²,6-diamidino-2-phenylindole; DIV; days in vitro; ER; estrogen receptor; E2; 17β-estradiol; GPR30; G-protein-co
Early effects of high glucose in retinal tissue cultures: Renin-Angiotensin system-dependent and -independent signaling
Keywords: آکت; Angiotensin II; Diabetic retinopathy; RAS; Müller glia; Synapses; CREB; Akt; Enalaprilat; High glucose; Retinal neuroglial compartment;
A COX-2 inhibitor nimesulide analog selectively induces apoptosis in Her2 overexpressing breast cancer cells via cytochrome c dependent mechanisms
Keywords: آکت; PI3K; phosphatidylinositol 3-kinase; AKT; protein kinase B; PDK; phosphoinositide-dependent kinase; MAPK; mitogen activated protein kinase; COX-2; cyclooxygenase 2; NSAIDs; non-steroidal anti-inflammatory drugs; PGE2; prostaglandin E2; Her2; human epiderm
Simvastatin acutely reduces ischemic brain damage in the immature rat via Akt and CREB activation
Keywords: آکت; Statins; Neuroprotection; Neurodegeneration; Hypoxia ischemia; Akt; CREB; Neonate
Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt
Keywords: آکت; Salivary adenoid cystic carcinoma; Metastasis; Epiregulin; ERK1/2; Akt
Pinoresinol-4,4′-di-O-β-d-glucoside from Valeriana officinalis root stimulates calcium mobilization and chemotactic migration of mouse embryo fibroblasts
Keywords: آکت; Pinoresinol-4,4′-di-O-β-d-glucoside; Valeriana officinalis; Lysophosphatidic acid; Migration; Phosphatidylinositol 3-kinase; Akt
Non-peptidic substrate-mimetic inhibitors of Akt as potential anti-cancer agents
Keywords: آکت; Akt; Protein kinase B; Substrate-mimetic; Cancer; Inhibitor
Carbohydrate scaffolds in chemical genetic studies
Keywords: آکت; Chemical genetics; Glycomimetics; Combinatorial library; Akt; NMR
Integrated modulation of phorbol ester-induced Raf activation in EL4 lymphoma cells
Keywords: آکت; PMA, phorbol 12-myristate 13-acetate; RT-PCR, reverse transcriptase polymerase chain reaction; siRNA, small interfering RNA; WT, wild-type (PMA-sensitive) EL4 cells.Tumor promoter; Mitogen-activated protein kinase; Akt; Erk; RKIP
Insulin inhibits leukocyte–endothelium adherence via an Akt-NO-dependent mechanism in myocardial ischemia/reperfusion
Keywords: آکت; Insulin; Myocardial ischemia/reperfusion; Endothelial cells; Polymorphonuclear leukocytes; Akt
Distinct response in maintenance of human naive and memory B cells via IL-21 receptor and TCL1/Akt pathways
Keywords: آکت; Naïve B cells; Memory B cells; Maintenance; Lifespan; IL-21 receptor; TCL1; Akt
3D cell cultures of human head and neck squamous cell carcinoma cells are radiosensitized by the focal adhesion kinase inhibitor TAE226
Keywords: آکت; Ionizing radiation; FAK; Akt; Squamous cell carcinoma; Three-dimensional cell culture
Butein suppresses c-Myc-dependent transcription and Akt-dependent phosphorylation of hTERT in human leukemia cells
Keywords: آکت; Butein; Telomerase; hTERT; c-Myc; Akt
Midkine positively regulates the proliferation of human gastric cancer cells
Keywords: آکت; Midkine; Gastric cancer; Akt; ERK1/2; Cell cycle
Notch-1 regulates Akt signaling pathway and the expression of cell cycle regulatory proteins cyclin D1, CDK2 and p21 in T-ALL cell lines
Keywords: آکت; Notch-1; T-cell acute lymphoblastic leukemia; Apoptosis; siRNA; Akt
Telmisartan induces proliferation of human endothelial progenitor cells via PPARγ-dependent PI3K/Akt pathway
Keywords: آکت; Telmisartan; PPARγ; EPCs; Akt; Proliferation; Senescence
Antifolate/folate-activated HGF/c-Met signalling pathways in mouse kidneys-the putative role of their downstream effectors in cross-talk with androgen receptor
Keywords: آکت; Cross-talk; Androgen receptor; HGF/c-Met; Akt; ERK1/2; GSK3β; Ornithine decarboxylase; Kidney-injury;
β-hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways
Keywords: آکت; HMB; Myoblast; Akt; Apoptosis; Proliferation; Differentiation; Skeletal muscle
Akt-dependent and -independent mechanisms of mTOR regulation in cancer
Keywords: آکت; mTOR; Cancer; Akt; AMPK
Concomitant supplementation of lycopene and eicosapentaenoic acid inhibits the proliferation of human colon cancer cells
Keywords: آکت; Lycopene; Eicosapentaenoic acid; Akt; mTOR; Proliferation; Colon cancer cells
Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer
Keywords: آکت; Prostate cancer; Tumor suppressor genes; Pten; Trp53; Mouse models; Pathology; AKT; Tissue recombinants; Embryonic mesenchyme
Transforming growth factor-β1 increases cell migration and β1 integrin up-regulation in human lung cancer cells
Keywords: آکت; TGF, transforming growth factor; ECM, extracellular matrix; PI3K, phosphatidylinositol 3-kinase; IKKα/β, IκB kinase α/β; NF-κB, nuclear factor-κBTGF-β1; Lung cancer; Integrin; Migration; NF-κB; Akt
SDF-1alpha up-regulates interleukin-6 through CXCR4, PI3K/Akt, ERK, and NF-kappaB-dependent pathway in microglia
Keywords: آکت; SDF-1α; Microglia; IL-6; NF-κB; ERK; Akt
Selective regulation of interleukin-10 production via Janus kinase pathway in murine conventional dendritic cells
Keywords: آکت; Dendritic cells; Toll-like receptors; Cytokines; Signal transduction; JAK; STAT; PI3K; Akt; MAPK; NF-κB
The role of Akt/GSK-3β signaling in familial hypertrophic cardiomyopathy
Keywords: آکت; Familial hypertrophic cardiomyopathy; Troponin T; Akt; Glycogen synthase kinase-3β (GSK-3β); Cardiomyopathy
Titin-based mechanical signalling in normal and failing myocardium
Keywords: آکت; Mechanosensing; Elasticity; Stiffness; Connectin; Z-disc; I-band; M-band; Protein kinase-G; Protein kinase-A; AKT
Dosage effects of EGb761 on hydrogen peroxide-induced cell death in SH-SY5Y cells
Keywords: آکت; EGb761; H2O2; Apoptosis; Akt; JNK; GSH
TrkA pathway activation induced by amyloid-beta (Abeta)
Keywords: آکت; Alzheimer; Amyloid beta peptide; NGF; TrkA; AKT; GSK-3β
SM934, a water-soluble derivative of arteminisin, exerts immunosuppressive functions in vitro and in vivo
Keywords: آکت; SM934; Artemisinin; TCR; IL-2; T lymphocytes; Apoptosis; Akt; Delayed type hypersensitivity