Overexpression of LAPTM4B-35 promotes growth and metastasis of hepatocellular carcinoma in vitro and in vivo
Keywords: آکت; LAPTM4B-35; HCC; Tumorigenesis; Cell cycle; AKT
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Neuropharmacology of the essential oil of bergamot
Keywords: آکت; Essential oil of bergamot (BEO); EEG spectrum power; Neurotransmitter release; Brain ischemia (MCAO); Akt; GSK-3β; Pain
Norepinephrine and nitric oxide promote cell survival signaling in hippocampal neurons
Keywords: آکت; Hippocampus; Norepinephrine; BDNF; Akt; CREB; Nitric oxide
Involvement of matrix metalloproteinase-3 in CCL5/CCR5 pathway of chondrosarcomas metastasis
Keywords: آکت; CCL5; Migration; CCR5; Chondrosarcoma; Akt
NGF-induced moesin phosphorylation is mediated by the PI3K, Rac1 and Akt and required for neurite formation in PC12 cells
Keywords: آکت; Moesin; NGF; Akt; PI3K; Rac1; Neurite outgrowth
Prosurvival role of JAK/STAT and Akt signaling pathways in MPP+-induced apoptosis in neurons
Keywords: آکت; MPP+; STAT3, Cerebellar granule cells; Akt; Apoptosis
Effect of transition metals in synaptic damage induced by amyloid beta peptide
Keywords: آکت; iron; copper; synaptosomes; Akt; ERK1/2; Aβ peptide; AD; Alzheimer's disease; ADDLs; amyloid-beta derived diffusible ligands; Aβ; amyloid-beta peptide; DMSO; dimethyl sulfoxide; EDTA; ethylenediaminetetraacetic acid; EM; electron microscopy; ERK1/2; ext
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
Keywords: آکت; PTEN; Akt; Cowden's syndrome; PIK3CA; Invasion; Anaplastic thyroid cancer; Follicular thyroid cancer
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling
Keywords: آکت; S1P; FTY720; Pak1; Akt
Activation status of receptor tyrosine kinase downstream pathways in primary lung adenocarcinoma with reference of KRAS and EGFR mutations
Keywords: آکت; Lung adenocarcinoma; Receptor tyrosine kinases; Survival; Akt; TTF-1; Signal pathway
Halofuginone inhibits Smad3 phosphorylation via the PI3K/Akt and MAPK/ERK pathways in muscle cells: Effect on myotube fusion
Keywords: آکت; Myoblast; PI3K; Akt; MAPK; Fusion; Muscular dystrophies
PTH inactivates the AKT survival pathway in the colonic cell line Caco-2
Keywords: آکت; PTH; Caco-2 cell; Apoptosis; PP2A; AKT;
Ames dwarf (Prop1df/Prop1df) mice display increased sensitivity of the major GH-signaling pathways in liver and skeletal muscle
Keywords: آکت; Ames dwarf mice; GH-signal transduction; GH; STAT; Erk; Akt
Transcriptional regulation of the insulin signaling pathway genes by starvation and 20-hydroxyecdysone in the Bombyx fat body
Keywords: آکت; InR; IRS; PI3K; PTEN; PDK; Akt; Transcriptional regulation; Starvation; 20-Hydroxyecdysone; Fat body; Bombyx mori
Geldanamycin and its analog induce cytotoxicity in cultured human retinal pigment epithelial cells
Keywords: آکت; geldanamycin; 17-AAG; Hsp70; Hsp90α; cell cycle; growth arrest; ERK1/2; Akt
Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide Subject
Keywords: آکت; Akt; depression; hippocampus; PDK1; prefrontal cortex; PTEN; suicide
Mechanical stretch and prostaglandin E2 modulate critical signaling pathways in mouse podocytes
Keywords: آکت; Podocytes; AKT; Prostaglandins; EP4; MAPK; EGFR
Rapamycin Inhibits Proliferation and Migration of Hepatoma Cells In Vitro
Keywords: آکت; mTOR; rapamycin; Akt; liver transplantation; hepatocellular carcinoma; metastasis
An antagonism between the AKT and beta-adrenergic signaling pathways mediated through their reciprocal effects on miR-199a-5p
Keywords: آکت; Hif-1α; hypoxia-inducible factor 1alpha; Sirt1; sirtuin-1; HPC; hypoxia preconditioning; miRNA; microRNA; IPC; ischemia preconditioning; TAC; transverse aortic constriction; caAKT; constitutively active AKT; ILK; integrin-linked kinase; βAR; beta-adrene
AKT loss in human epithelial cells treated with severe hypoxia
Keywords: آکت; AKT; Hypoxia; Proteolysis; Autophagy; Inhibitor
Suppression of DNA-PKcs enhances FGF-2 dependent human endothelial cell proliferation via negative regulation of Akt
Keywords: آکت; DNA-PK; Endothelial cells; Proliferation; Akt; Fibroblast growth factor;
Hypoxic preconditioning provides neuroprotection and increases vascular endothelial growth factor A, preserves the phosphorylation of Akt-Ser-473 and diminishes the increase in caspase-3 activity in neonatal rat hypoxic-ischemic model
Keywords: آکت; Akt; protein kinase B; HI; hypoxia-ischemia or hypoxic-ischemic; HIF-1; Hypoxia-inducible factor 1; LH; left hemisphere; PC; hypoxic preconditioning; RH; right hemisphere; VEGF; Vascular endothelial growth factor A; Neurotrophin; Neuroprotection; Apop
Activation of phosphatidylinositol 3-kinase/Akt-mammalian target of Rapamycin signaling pathway in the hippocampus is essential for the acquisition of morphine-induced place preference in rats
Keywords: آکت; morphine; conditioned place preference; hippocampus; Akt; mTORCPP, conditioned place preference; GFAP, glial fibrillary acidic protein; Iba1, ionized calcium adaptor-binding protein 1; LTP, long-term potentiation; mTOR, mammalian target of Rapamycin; NAc,
Ellagic acid protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway
Keywords: آکت; Ellagic acid; Endothelium; Apoptosis; ROS; oxLDL; Akt
Modulation of acute and chronic inflammatory processes by a traditional medicine preparation GCSB-5 both in vitro and in vivo animal models
Keywords: آکت; GCSB-5; Acute and chronic inflammation; iNOS; NF-κB; Akt
Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells
Keywords: آکت; Cetuximab; Gefitinib; Acquired resistance; PTEN; Akt
15-HETE protects rat pulmonary arterial smooth muscle cells from apoptosis via the PI3K/Akt pathway
Keywords: آکت; 15-Hydroxyeicosatetraenoic acid; Rat pulmonary artery muscle smooth cells; Hypoxia-induced pulmonary hypertension; Apoptosis; Akt;
Down-regulation of Bcl-2 and Akt induced by combination of photoactivated hypericin and genistein in human breast cancer cells
Keywords: آکت; Hypericin; Genistein; Photodynamic therapy; Bcl-2; Akt; Breast cancer
Abrogation of Akt signaling by Isobavachalcone contributes to its anti-proliferative effects towards human cancer cells
Keywords: آکت; Isobavachalcone; Akt; Computational simulation; Anti-proliferative effect; Chemotherapy
Triptolide Induces Cell Death in Pancreatic Cancer Cells by Apoptotic and Autophagic Pathways
Keywords: آکت; Autophagy; Apoptosis; Pancreatic Cancer; Cell Death; Akt; Protein Kinase B; ERK; Extracellular Signal-Related Kinase; Hsp; heat shock protein; LC; Light chain; mTOR; mammalian target of Rapamycin; siRNA; short interfering RNA;
Down-regulation of the JAK2/PI3K-mediated signaling activation is involved in Taiwan cobra cardiotoxin III-induced apoptosis of human breast MDA-MB-231 cancer cells
Keywords: آکت; Akt; Cobra venom; Cardiotoxin; JAK2; MDA-MB-231 cells; PI3K; STAT3
Mammalian target of rapamycin is a biomarker of poor survival in metastatic serous ovarian carcinoma
Keywords: آکت; AKT; mTOR; DJ-1; Serous ovarian carcinoma; Effusions; Survival
PI3-kinase p110α mediates β1 integrin-induced Akt activation and membrane protrusion during cell attachment and initial spreading
Keywords: آکت; β1 integrin; PI3K; p110α; Cell spreading; Akt
Oleate dose-dependently regulates palmitate metabolism and insulin signaling in C2C12 myotubes
Keywords: آکت; Akt; protein kinase B; ANOVA; one-way analysis of variance; ASP; acid-soluble products; BSA; bovine serum albumin; C2; C2-carnitine; DAG; diacylglycerides; DGAT; diacylglycerol acyltransferase; DMEM; Dulbecco's modified Eagle's medium; FCS; Fetal calf ser
Adenovirus-driven overexpression of proteinases in organ-cultured normal human corneas leads to diabetic-like changes
Keywords: آکت; Diabetic cornea; Organ culture; MMP-10; Cathepsin F; Akt; Sildenafil
Modulators of the hedgehog signaling pathway
Keywords: آکت; Antitumor agents; Cyclopamine; Hedgehog signaling; AKT; protein kinase B; ALP; alkaline phosphatase; BCC; basal cell carcinoma; BCR-ABL1; breakpoint cluster region-Abelson murine leukemia; β-TrCP; β-transducin repeat containing protein; BMP; bone morpho
A non-catalytic function of the Src family tyrosine kinases controls prolactin-induced Jak2 signaling
Keywords: آکت; Prolactin; Src family kinases; Src scaffold functions; Jak2; Stat5; Akt; Erk1/2; Cell proliferation;
Cardiomyocyte-targeted overexpression of the coxsackie-adenovirus receptor causes a cardiomyopathy in association with β-catenin signaling
Keywords: آکت; CAR; coxsackie-adenovirus receptor; DCM; dilated cardiomyopathy; CVB; coxsackievirus group B; mCAR; murine CAR; β-gal; β-galactosidase; tTA; tetracycline transactivator; PBS; phosphate buffered saline; αMHC; α-myosin heavy chain; αMtTa; α-myosin h
IGF-1 Mediates PTEN Suppression and Enhances Cell Invasion and Proliferation via Activation of the IGF-1/PI3K/Akt Signaling Pathway in Pancreatic Cancer Cells
Keywords: آکت; Akt; IGF-1; pancreatic cancer; PTEN
Extracellular signal-regulated kinase and phosphatidylinositol-3-kinase/AKT signalling pathways in the human carotid body and peripheral ganglia
Keywords: آکت; ERK; AKT; Immunohistochemistry; Carotid body; Ganglia; Human;
Expansion of Hepatic Tumor Progenitor Cells in Pten-Null Mice Requires Liver Injury and Is Reversed by Loss of AKT2
Keywords: آکت; Liver Cancer Stem Cells; DDC; Lipotoxic Cell Death; Mixed-Lineage Tumors; AFP; α-fetoprotein; Akt; protein kinase B; Alb; albumin; DDC; 3,5-dietoxycarbonyl-1,4 dihydrocollidine; Dm; Pten/Akt2 double mutant; HepPar; hepatocyte paraffin; 4-HNE; trans-4-hyd
Clinical Advances in Liver, Pancreas, and Biliary TractInsulin-Like Growth Factor Axis Gene Polymorphisms and Clinical Outcomes in Pancreatic Cancer
Keywords: آکت; Pancreatic Cancer; Insulin-Like Growth Factor-Axis; Single-Nucleotide Polymorphism; Overall Survival; AKT; v-akt murine thymoma viral oncogene homolog; ERK; extracellular signal-regulated kinase; FDR; false discovery rate; IGF; insulin-like growth facto
Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models
Keywords: آکت; glutamate; immortalization; cell biology; signal transduction; hippocampus; membrane estrogen receptor; Akt; homologous enzyme sequence of viral oncogene v-akt isolated from AKR mouse spontaneous thymoma cell line and also called protein kinase B; AR; and
Taiwan cobra cardiotoxin III inhibits Src kinase leading to apoptosis and cell cycle arrest of oral squamous cell carcinoma Ca9-22 cells
Keywords: آکت; Akt; Ca9-22 cells; CTX III; PI3 K; Src; STAT
Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity
Keywords: آکت; 17 β-TBOH; trenbolone; 17 α-TBOH; epitrenbolone; 17β-E2; estradiol; AR; androgen receptor; Akt; serine/threonine-specific kinase family; ACTH; adrenocorticotropic hormone; BMD; bone mineral density; Ca2+; calcium; CSA; cross-sectional area; DHT; dihydr
The Hormone Receptor GUCY2C Suppresses Intestinal Tumor Formation by Inhibiting AKT Signaling
Keywords: آکت; AKT; v-akt murine thymoma viral oncogene homolog; APC; adenomatous polyposis coli; FOXO; the forkhead box O transcription factor; GUCY2C; guanylyl cyclase C; GLUT1; glucose transporter 1; HKII; hexokinase II; PTEN; phosphatase and tensin homolog; siRNA; s
AKT regulates BRCA1 stability in response to hormone signaling
Keywords: آکت; BRCA1; Estrogen; Breast cancer; AKT; IGF1; Proteasome; Phosphorylation
Pharmacodynamic Characterization of the Efficacy Signals Due to Selective BRAF Inhibition with PLX4032 in Malignant Melanoma
Keywords: آکت; AKT; v-akt murine thymoma viral oncogene homolog; ANOVA; analysis of variance; ATCC; American Type Culture Collection; BRAF; v-raf murine sarcoma viral oncogene homolog B1; BRAFm; BRAF mutation; CKIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene
PI 3-kinase/Akt and STAT3 are required for the prevention of TGF-β-induced Hep3B cell apoptosis by autocrine motility factor/phosphoglucose isomerase
Keywords: آکت; AMF/PGI; TGF-β; PI 3-kinase; Akt; STAT3
Cardiac overexpression of insulin-like growth factor 1 attenuates chronic alcohol intake-induced myocardial contractile dysfunction but not hypertrophy: Roles of Akt, mTOR, GSK3β, and PTEN
Keywords: آکت; Alcohol; Cardiac hypertrophy; Contractile function; Intracellular Ca2+; Akt; mTOR; GSK3β; Foxo3a; Free radicals