کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10847729 | 1070423 | 2010 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity
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کلمات کلیدی
BMDGSK3PLCHPG17β-E2IGF-1IGF-1RHRERAF-1gonadectomizedTrenboloneERKACTHGnRHDHTPI3Klymphoid enhancer factor 1Ca2+ - Ca2 +MAPK - MAPKAkt - آکتEstradiol - استرادیولCSA - ایالات مؤتلفهٔ آمریکاIschemia reperfusion - ایسکمی reperfusionBone mineral density - تراکم معدنی استخوانDihydrotestosterone - دی هیدروتستوسترونextracellular signal regulated kinases - سیگنال خارج سلولی kinases را تنظیم می کندinsulin-like growth factor 1 - فاکتور رشد مانند انسولین 1Phosphatidylinositol 3-kinase - فسفاتیدیلینواستیل 3-کینازphospholipase C - فسفولیپاز CLef - لفMEK - مجاهدین خلقHypothalamic-pituitary-gonadal axis - محور هیپوتالاموس-هیپوفیز-گنادcross-sectional area - مقطع عرضیadrenocorticotropic hormone - هورمون adrenocorticotropicGonadotropin-releasing hormone - هورمون آزاد کننده گنادوتروپینluteinizing hormone - هورمون جسم زردFSH - هورمون محرکه فولیکولی G-protein - پروتئین Gmitogen activated protein kinase - پروتئین کیناز فعال Mitogen فعال استCalcium - کلسیمglycogen synthase kinase-3 - گلیکوزین سنتاز کیناز 3Androgen Receptor - گیرنده آندروژنیinsulin-like growth factor 1 receptor - گیرنده فاکتور رشد 1 مانند انسولینfrizzled receptor - گیرنده فریزلestrogen receptors - گیرنده های استروژنglucocorticoid receptors - گیرنده های گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity Tissue selectivity and potential clinical applications of trenbolone (17β-hydroxyestra-4,9,11-trien-3-one): A potent anabolic steroid with reduced androgenic and estrogenic activity](/preview/png/10847729.png)
چکیده انگلیسی
Recently, the development of selective androgen receptor modulators (SARMs) has been suggested as a means of combating the deleterious catabolic effects of hypogonadism, especially in skeletal muscle and bone, without inducing the undesirable androgenic effects (e.g., prostate enlargement and polycythemia) associated with testosterone administration. 17β-Hydroxyestra-4,9,11-trien-3-one (trenbolone; 17β-TBOH), a synthetic analog of testosterone, may be capable of inducing SARM-like effects as it binds to androgen receptors (ARs) with approximately three times the affinity of testosterone and has been shown to augment skeletal muscle mass and bone growth and reduce adiposity in a variety of mammalian species. In addition to its direct actions through ARs, 17β-TBOH may also exert anabolic effects by altering the action of endogenous growth factors or inhibiting the action of glucocorticoids. Compared to testosterone, 17β-TBOH appears to induce less growth in androgen-sensitive organs which highly express the 5α reductase enzyme (e.g., prostate tissue and accessory sex organs). The reduced androgenic effects result from the fact that 17β-TBOH is metabolized to less potent androgens in vivo; while testosterone undergoes tissue-specific biotransformation to more potent steroids, dihydrotestosterone and 17β-estradiol, via the 5α-reductase and aromatase enzymes, respectively. Thus the metabolism of 17β-TBOH provides a basis for future research evaluating its safety and efficacy as a means of combating muscle and bone wasting conditions, obesity, and/or androgen insensitivity syndromes in humans, similar to that of other SARMs which are currently in development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Steroids - Volume 75, Issue 6, June 2010, Pages 377-389
Journal: Steroids - Volume 75, Issue 6, June 2010, Pages 377-389
نویسندگان
Joshua F. Yarrow, Sean C. McCoy, Stephen E. Borst,