Keywords: 4- Shogaol (PubChem CID: 9794897); 6- Shogaol (PubChem CID: 5281794); Apigenin (PubChem CID: 5280443); Berberine (PubChem CID: 2353); Bergamottin (PubChem CID: 5471349); Caffeic acid (PubChem CID: 689043)Capsaicin (PubChem CID: 1548943); Cardamonin (PubCh
مقالات ISI (ترجمه نشده)
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Keywords: PI3K; phosphoinositide 3-kinase; MAPK; mitogen activated protein kinase; mTORC1; mTOR complex 1; GCN2; general control nonderepressible 2; ULK; UNC-5 like autophagy activating kinase; ATG; autophagy related gene; GPCR; G protein coupled receptor; UCPs; un
Keywords: PSD; post stroke depression; DSM; diagnostic and statistical manual of mental disorders; HPA; hypothalamo-pituitary-adrenal axis; DEPRESS; depression predictors after ischemic stroke; MRI; magnetic resonance imaging; CES-D; center for epidemiological stud
Keywords: Bax; Bcl-2-associated protein x; Bcl-2; B-cell lymphoma 2; BE; Barrett's esophagus; BMI; body mass index; c-Jun; Jun proto-oncogene; CRA; colorectal adenoma; CRC; colorectal cancer; COX; cyclooxygenase; EAC; esophageal adenocarcinoma; GERD; gastroesophage
Keywords: EGFR; Epidermal growth factor receptor; TP53; Tumor protein p53; KRAS; Kirsten rat carcoma viral oncogene; ALK; Anaplastic lymphoma kinase; RTK; Protein receptor tyrosine kinase; TKI; Tyrosine kinase inhibitor; PI3K; Phosphatidylinositol 3-kinase; NSCLC;
Keywords: IGF-1; IGFBP5; IGF-1R; Motoneuron; Myelination; Axonal degeneration; Neuropathy; Diabetic polyneuropathy; Amyotrophic lateral sclerosis; Alzheimer;
Keywords: CBL; casitas B-lineage lymphoma; CtxR; cetuximab-resistant; CtxS; cetuximab-sensitive; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial to mesenchymal transition; EPR; epiregulin; FDA; food and
Keywords: Diabetes mellitus; Cancer risk; Insulin; Antidiabetic drugs; ATP; adenosine triphosphate; BMI; body mass index; CI; confidence interval; DDDs; defined daily doses; DNA; deoxyribonucleic acid; DPP-4 inhibitors; dipeptidyl peptidase-4 inhibitors; Egr-1; ear
Keywords: HOMA-IR; Diabetes Drug; Cancer Development; Tumorigenesis; AE; adverse event; AMP; adenosine monophosphate; AMPK; adenosine monophosphate-activated protein kinase; BE; Barrett's esophagus; BMI; body mass index; EAC; esophageal adenocarcinoma; EGD; eso
Keywords: Antibodies; Immunoconjugates; Immunotoxins; Ab; antibody; Ag; antigen; ADCC; antibody-dependent cell mediated cytotoxicity; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AKT; protein kinase B; APC; antigen-presenting cell; Apo2L/TRAIL; t
Keywords: AKAP; A-Kinase Anchoring Protein; ALL; acute lymphoblastic leukemia; A.S.; activation segment; CDK; cyclin-dependent kinase; CML; chronic myelogenous leukemia; C-spine; catalytic spine; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth facto
Keywords: HER2; human epidermal growth factor receptor 2; HER3; human epidermal growth factor receptor 3; HRG; heregulin; IGF-1R; insulin-like growth factor-1 receptor; IGF-1; insulin-like growth factor-1; pAKT; phosphorylated AKT; dsIgG; dual-specific IgG; Immunog
Keywords: ADAM; (a disintegrin and metalloprotease) metallopeptidase; ALPs; alkyl-lysophospholipids; CD24; signal transducer CD24 (glycosylphosphatidylinositol-anchored receptor); CD44; CD44 antigen (receptor for hyaluronic acid); CXCR4; chemokine receptor type 4;
Keywords: ESFT; Ewing's sarcoma family tumors; ES; Ewing's sarcoma; MCTS; multicellular tumor spheroids; 3D; three-dimensional; PCL; poly(ε-caprolactone); ECM; extracellular matrix; PDX; patient-derived tumor explants; MSC; mesenchymal stem cells; EC; endothelial
Keywords: Bortezomib; Multiple myeloma; IGF-1R; Syndecan 1;
Keywords: Colon cancer; Proliferation; Glucagon-like peptide 2; Cancer therapy; (5-FU); 5-Fluorouracil; Akt; protein kinase B; APC; adenomatous polyposis coli; CAFs; carcinoma-associated fibroblasts; CDK; cyclin-dependent kinase; DPP-IV; dipeptidyl peptidase IV; GL
Keywords: IGFs; insulin-like growth factors; SHBG; sex hormone binding globulin; BMI; body mass index; IGFBPs; IGF binding proteins; IGF-1R; insulin-like growth factor-1 receptor; CLS; crown-like structure; NFκB; nuclear factor kappa-B; STAT3; signal transducer an
Keywords: ACF; aberrant crypt foci; AMC; 7-amino-4-methyl coumarin; Akt1; v-akt murine thymoma viral oncogene homolog 1; ATCC; American Type Culture Collection; CCL; culture clone; CHO; Chinese hamster ovary cells; CPA; cyclopiazonic acid; D9R; nona-d-arginine; DME
Keywords: AML; acute myeloid leukemia; CAM-DR; cell adhesion-mediated drug resistance; CCP; charge-conversion polymer; CLL; chronic lymphocytic leukemia; CNS; central nervous system; CSC; cancer stem cell; EGFR; epidermal growth factor receptor; EPR; enhanced perme
Keywords: Angiogenesis; Antiangiogenic agents; Angiogenic cytokines/peptides; EC; endothelial cells; VEGF; vascular endothelial growth factor; VEGF Receptor; VEGFR; FGF; fibroblast growth factor; EGF; epidermal growth factor; epidermal growth factor receptor; EGFR;
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; ADAMTS9; ADAM metallopeptidase with thrombospondin type 1 motif, 9; ARID1A; AT rich interactive domain 1A (SWI-like); AML; Acute myelocytic leukemia; ATBF1; A
The mechanisms and clinical significance of PDCD4 in colorectal cancer
Keywords: Abbreviations; Full name in English; 3â²-UTR; 3â²-untranslated region; AA; asiatic acid; AOM; azoxymethane; AP-1; activating protein 1; AR; aldose reductase; ATF; activating transcription factor; Bcl-2; B-cell lymphoma 2; CAC; colitis-associated CRC; CD
Strategies of biochemical adaptation for hibernation in a South American marsupial, Dromiciops gliroides: 2. Control of the Akt pathway and protein translation machinery
Keywords: 4EBP; eukaryotic translation initiation factor 4E-binding protein; Akt; protein kinase B; eIF2α; eukaryotic translation initiation factor 2A; eIF4e; eukaryotic translation initiation factor 4E; GSK-3α; glycogen synthase kinase 3 alpha; GSK-3β; glycogen
Inhibition of IGF1R enhances 2-deoxyglucose in the treatment of non-small cell lung cancer
Keywords: 2-DG; 2-deoxyglucose; IGF-1R; insulin-like growth factor 1 receptor; NSCLC; non-small cell lung cancer; PARP; poly ADP ribose polymerase; Cancer therapy; Energy metabolism; Insulin-Like growth factor receptor 1 (IGF1R); Lung cancer; Tumor suppressor gene;
Low-expressional IGF1 mediated methimazole-induced liver developmental toxicity in fetal mice
Keywords: IGF-1R; insulin-like growth factor-1 receptor; Akt2; serine-threonine protein kinase 2; HMGCR; HMG CoA reductase; FASN; fatty acid synthase; PEPCK; phosphoenolpyruvate carboxykinase; PCNA; proliferating cell Nuclear antigen; HNF4α; hepatocyte nuclear fac
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
Necroptosis in 3-chloro-1, 2-propanediol (3-MCPD)-dipalmitate-induced acute kidney injury in vivo and its repression by miR-223-3p
Keywords: 3-MCPD; 3-chloro-1,2-propanediol; 3â²UTR; 3â² un-translated region; AKI; acute kidney injury; BMD10; Benchmark doses; BMDL10; BMD Lower Confidence Limit; BW; body weight; CXCl; chemokine (C-X-C motif) ligand; DE; differentially expressed; DR6; death rec
MicroRNAs link chronic inflammation in childhood to growth impairment and insulin-resistance
Keywords: ALS; acid-labile subunit; APC; antigen-presenting cell; CXCL2; chemokine (C-X-C motif) ligand 2; ESR; erythrocyte sedimentation rate; FGFR1; fibroblast growth factor receptor 1; FOXO1; Forkhed box O1; FOXP3; forkhead box P3; GH; growth hormone; GHR; growt
CaMKIIα expression in a mouse model of NMDAR hypofunction schizophrenia: Putative roles for IGF-1R and TLR4
Keywords: Schizophrenia; NMDAR; IGF-1R; CaMKIIα MAPK/ErK; TLR4;
Hrd1 induces cardiomyocyte apoptosis via regulating the degradation of IGF-1R by sema3a
Keywords: AMI; Cardiomyocyte apoptosis; Hrd1; sema3a; IGF-1R;
Understanding the biology of HER3 receptor as a therapeutic target in human cancer
Keywords: Ab; antibody; ADCC; antibody-dependent cell-mediated cytotoxicity; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; FDA; Food and Drug Administration; HER; Human epidermal growth factor receptor; HRG; heregulin; IGF-1R; insu
The interaction of IGF-1/IGF-1R and hydrogen sulfide on the proliferation of mouse primary vascular smooth muscle cells
Keywords: BrdU; bromodeoxyuridine; CBS; cystathionine-beta-synthase; CRISPR; clustered regularly interspaced short palindromic repeats; CSE; cystathionine-gamma-lyase; DMEM; dulbecco's modified eagle's medium; ERK; extracellular regulated protein kinase; FBS; f
MiR-1275 promotes cell migration, invasion and proliferation in squamous cell carcinoma of head and neck via up-regulating IGF-1R and CCR7
Keywords: SCCHN; Squamous cell carcinoma of head and neck; IGF-1R; insulin like growth factor 1 receptor; CCR7; C-C chemokine receptor type 7; cDNA; DNA complementary to RNA; UTR; untranslated region(s); TCGA; The Cancer Genome Atlas database; RT-PCR; Real-time pol
Exosomes and regenerative medicine: state of the art and perspectives
Keywords: adMSCs; adipose-derived MSCs; AIS; acute ischemic stroke; AKI; acute kidney injury; AMI; acute myocardial infarction; BMP-7; bone morphogenetic protein 7; CCl4; carbon tetrachloride; CDCs; cardiosphere-derived cells; CM; conditioned medium; CPCs; cardiac
CD52, CD22, CD26, EG5 and IGF-1R expression in thymic malignancies
Keywords: CD52; CD22; CD26; EG5; IGF-1R; Thymic;
Phase I clinical trials in patients with advanced non-small cell lung cancer treated within a Drug Development Unit: What have we learnt?
Keywords: ALK; Anaplastic Lymphoma Kinase; DDU; Drug Development Unit; ECOG PS; Eastern Cooperative Oncology Group performance status; EGFR; epidermal growth factor receptor; EPR; electronic patient record; HDAC; histone deacetylase; IGF-1R; insulin growth factor-1
Mild hypothermia pretreatment protects hepatocytes against ischemia reperfusion injury via down-regulating miR-122 and IGF-1R/AKT pathway
Keywords: Mild hypothermia pretreatment; microRNA-122; Ischemia reperfusion; IGF-1R; AKT;
Neuroprotective properties of icariin in MPTP-induced mouse model of Parkinson's disease: Involvement of PI3K/Akt and MEK/ERK signaling pathways
Keywords: Icariin; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Phosphatidylinositol 3-kinase; Mitogen-activated protein kinase kinase; Dopamine; Parkinson's disease; DA; dopamine; IGF-1R; insulin-like growth factor-1 receptor; IRS-1; insulin receptor substrate-1;
The impact of the IGF-1 system of cancer cells on radiation response - An in vitro study
Keywords: IGF-1R; insulin-like growth factor 1 receptor; SF; surviving fractions; IGF-1R/KR; kinase-deficient IGF-1R; Caco-2-KR4; IGF-1R/KR clone number 4; IRS-1; insulin receptor substrate 1; HRR; homologous recombination repair; NHEJ; non-homologous end joining;
The activation of the G protein-coupled estrogen receptor (GPER) inhibits the proliferation of mouse melanoma K1735-M2 cells
Keywords: G protein-coupled estrogen receptor (GPER); Melanoma; Antiestrogens; Proliferation; BCA; bicinchoninic acid; BrdU; 5-bromo-2â²-deoxyuridine; CYP; cytochrome P450; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; DTT; dithiothreitol; EC
IGF system targeted therapy: Therapeutic opportunities for ovarian cancer
Keywords: IGF system; Ovarian cancer; IGF-1R; Insulin receptor; Targeted therapy; System rewiring;
Embryonic-only arsenic exposure in killifish (Fundulus heteroclitus) reduces growth and alters muscle IGF levels one year later
Keywords: Arsenic; Killifish; Embryo; IGF-1; IGF-1R; Skeletal muscle;
Nicotinamide nucleotide transhydrogenase (NNT) deficiency dysregulates mitochondrial retrograde signaling and impedes proliferation
Keywords: 3-BrPA; 3-bromopyruvate; ÎΨm; mitochondrial membrane potential; DMS; dimethyl succinate; HDAC; histone deacetylase; ETC; electron transport chain; HIF-1; hypoxia-inducible factor 1; IGF-1R; insulin-like growth factor 1 receptor; IDH; isocitrate dehydrog
Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy
Keywords: CaMKIIα; calcium calmodulin-dependent kinase 2 alpha; HMGB1; high mobility group box protein 1; IGF-1; insulin-like growth factor 1; IGF-1R; IGF-1 receptor type 1; KCa2.2; calcium-dependent potassium channel (SK2 or KCNN2 family); TLR4; toll-like recepto
IGF-1 receptor haploinsufficiency leads to age-dependent development of metabolic syndrome
Keywords: IGF-1; IGF-1R; Igf1r+/-; Haploinsufficiency; SGA; Insulin; Type 2 diabetes; Metabolic syndrome; Lipogenesis;
S-nitrosylation of the IGF-1 receptor disrupts the cell proliferative action of IGF-1
Keywords: Insulin-like growth factor; Nitric oxide; S-Nitrosylation; Signal transduction; ERK; extracellular signal-regulated protein kinase; IGF-1; insulin-like growth factor-1; IGF-1R; insulin-like growth factor-1 receptor; IRS; insulin receptor substrate; MAPK;
Dual sphingosine kinase inhibitor SKI-II enhances sensitivity to 5-fluorouracil in hepatocellular carcinoma cells via suppression of osteopontin and FAK/IGF-1R signalling
Keywords: Hepatocellular carcinoma; Sphingosine kinase; SKI-II; Osteopontin; IGF-1R; SIRT1;
IR and IGF-1R expression affects insulin induced proliferation and DNA damage
Keywords: IR; insulin receptor; IGF-1R; insulin like growth factor-1 receptor; IGF-1; insulin like growth factor-1 inhibitor; PPP; 5R,5aS,8aR,9R)-9-hydroxy-5,8,8a,9-tetrahydro-5-(3,4,5-trimethoxyphenyl)-furo [3_,4_:6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one); Insuli
The role of miRNA-223 in cancer: Function, diagnosis and therapy
Keywords: miRNAs; MicroRNAs; UTR; The 3â² untranslated region; oncomiRs; Oncogenic miRNAs; miR-223; miRNA-223; T-ALL; T-cell acute lymphoblastic leukemia; AML; Acute myeloid leukemia; NSCLC; Nonsmall cell lung cancer; C/EBP; CCAAT-enhancer-binding protein; NFI-A;
Systemic analysis of different colorectal cancer cell lines and TCGA datasets identified IGF-1R/EGFR-PPAR-CASPASE axis as important indicator for radiotherapy sensitivity
Keywords: GEO; Gene Expression Omnibus; Colorectal cancer; Radiotherapy; qRT-PCR; Flow cytometry; TCGA; IGF-1R; EGFR;