RBx10080307, a dual EGFR/IGF-1R inhibitor for anticancer therapy
Keywords: IGF-1R; EGFR; Signaling pathway; Cancer; Resistance; Mutant cell line
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Autophagy induced by silibinin protects human epidermoid carcinoma A431 cells from UVB-induced apoptosis
Keywords: UVB; Silibinin; Autophagy; Apoptosis; IGF-1R; A431 cell
Insulino-mimetic and anti-diabetic effects of zinc
Keywords: Zinc; Organo-zinc compounds; Diabetes; Insulin-mimicker; PKB; IGF-1R
Gastrointestinal Stromal Tumors
Keywords: GIST; Tyrosine kinase inhibitors; SDH-deficient GIST; KIT; PDGFRA; IGF-1R; HSP90;
Efficacy of the novel dual PI3-kinase/mTOR inhibitor NVP-BEZ235 in a preclinical model of adrenocortical carcinoma
Keywords: ACC; adrenocortical carcinoma; IGF-1R; IGF-1 receptor; PI3K; PI3 kinase; mTOR; mammalian target of rapamycin; Adrenal; Cancer; Pharmacology; Signalling;
Clinico-pathologic comparison of type II endometrial cancers based on tamoxifen exposure
Keywords: Type II endometrial cancer; Tamoxifen; IGF-1R; mTOR
Insulin-like growth factor system on adrenocortical tumorigenesis
Keywords: IGF system; IGF2; Beckwith–Wiedemann syndrome; IGF-1R; IGFBPs; Sporadic adrenocortical tumors
Expressions of Insulin-Like Growth Factor Receptor-1 and Insulin-Like Growth Factor Binding Protein 3 in Advanced Non–Small-Cell Lung Cancer
Keywords: Adenocarcinoma; IGFBP3; IGF-1R; Insulin-like growth factor binding protein 3; Insulin-like growth factor receptor-1; Non–small-cell lung cancer; Squamous cell carcinoma
Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats
Keywords: Brain; Development; Stress; BDNF; TrkB; IGF-1; IGF-1R;
Induction of IGF-1R expression by EGR-1 facilitates the growth of prostate cancer cells
Keywords: EGR-1; IGF-1R; Tumor proliferation; Prostate cancer
Depletion of the type 1 IGF receptor delays repair of radiation-induced DNA double strand breaks
Keywords: IGF; Type 1 IGF receptor; IGF-1R; Prostate cancer; DNA double strand break; DNA repair
Cellular distribution of the IGF-1R in corneal epithelial cells
Keywords: cornea; epithelium; IGF-1R; E-cadherinEGFR, epidermal growth factor receptor; ER, endoplasmic reticulum; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GM130, Golgi matrix protein; hTCEpi, human telomerized corneal epithelial cells; IGF-I, insulin-like
Elevated IGFBP3 Levels in Diabetic Tears: A Negative Regulator of IGF-1 Signaling in the Corneal Epithelium
Keywords: Diabetes; cornea; epithelium; tears; IGFBP3; IGF-1; IGF-1R
Identification of biomarkers to distinguish clear cell sarcoma from malignant melanoma
Keywords: BRAF mutations; Clear cell sarcoma; EWSR1/ATF1 fusion transcripts; IGF-1R; Malignant melanoma; NRAS mutations
Downregulation of miR-223 and miR-153 mediates mechanical stretch-stimulated proliferation of venous smooth muscle cells via activation of the insulin-like growth factor-1 receptor
Keywords: Vascular smooth muscle cells; VSMCs; Insulin-like growth factor-1 receptor; IGF-1R; MiR-223; MiR-153; PI3K-AKT pathway;
Cognitive, Behavioral, and Systems NeuroscienceResearch PaperSpatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Keywords: spatial learning; memory; hippocampus; physical exercise; water maze; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent kinase II; IGF-1; insulin-like growth factor 1; IGF-1R; receptor for IGF-1;
Tumor-targeted Nanobullets: Anti-EGFR nanobody-liposomes loaded with anti-IGF-1R kinase inhibitor for cancer treatment
Keywords: EGFR; IGF-1R; Nanobody; Immunoliposomes; Combination therapy
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models
Keywords: AUC; area under the curve; CH; compound heterozygote; CS; Cockayne syndrome; GG-NER; global genome NER; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor receptor; IR; ionizing radiation; MDF; mouse dermal fibroblast; MEF; mouse embr
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway
Keywords: PAPP-A; pregnancy-associated plasma protein-A; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor 1 receptor; PI3-K; phosphatidylinositol 3-kinase; Akt; Akt kinase or protein kinase B (PKB); ABCA1; ATP-binding cassette transporter A1;
Src kinases catalytic activity regulates proliferation, migration and invasiveness of MDA-MB-231 breast cancer cells
Keywords: SFKs; Src family tyrosine kinases; EGF-R; epidermal growth factor receptor; PDGF-R; platelet-derived growth factor receptor; IGF-1R; insulin-like growth factor-1 receptor; VEGF-R; vascular endothelial growth factor receptor; FGF-R; fibroblast growth facto
The role of the insulin-like growth factor signaling pathway in non-small cell lung cancer and other solid tumors
Keywords: IGF; IGF-1R; Figitumumab; Cixutumumab; Robatumumab; Dalotuzumab
Birds and longevity: Does flight driven aerobicity provide an oxidative sink?
Keywords: CR; caloric restriction; DCA; dichloroacetic acid; ETF; electron transfer flavoprotein; ETS; electron transport system; FOXO1; Forkhead box protein O1; H2O2; hydrogen peroxide; Gp; DHglycerol 3-phosphate dehydrogenase; IGF-1R; insulin-like-growth factor r
Progress of molecular targeted therapies for prostate cancers
Keywords: Prostate cancer; EGFR; IGF-1R; VEGFR; Androgen; Hormone resistant
Development of tetravalent IgG1 dual targeting IGF-1R-EGFR antibodies with potent tumor inhibition
Keywords: Antibody engineering; Bispecific antibodies; Single chain Fv; IGF-1R; EGFR; GA201; R1507;
Oncogenic Pathways, Molecularly Targeted Therapies, and Highlighted Clinical Trials in Non–Small-Cell Lung Cancer (NSCLC)
Keywords: MET; EGFR; EML4-ALK; IGF-1R; KRAS; LKB1; Lung cancer; PI3K; Targeted therapies
Redox-regulating role of insulin: The essence of insulin effect
Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice
Keywords: IGF-1; IGF-1R; Igf1r+/−; SGA; HFD; Type 2 diabetes
BCL-2, in combination with MVP and IGF-1R expression, improves prediction of clinical outcome in complete response cervical carcinoma patients treated by radiochemotherapy
Keywords: BCL-2; Ku70/80; Major vault protein (MVP); IGF-1R; Cervical cancer
Discovery of the first non-ATP competitive IGF-1R kinase inhibitors: Advantages in comparison with competitive inhibitors
Keywords: IGF-1R; Kinase inhibitors; ATP; Noncompetitive; Slow binding inhibitor
IGF-1R expression predicts clinical outcome in patients with locally advanced oral squamous cell carcinoma
Keywords: IGF-1R; Oral cancer; Clinical outcome; Radiotherapy
Discovery of 2,4-bis-arylamino-1,3-pyrimidines as insulin-like growth factor-1 receptor (IGF-1R) inhibitors
Keywords: Insulin-like growth factor-1 receptor; IGF-1R; Kinase; Pyrimidine; Calu-6 xenograft; X-ray cocrystal structure
Insulin-like growth factor binding protein-3, in association with IGF-1 receptor, can predict prognosis in squamous cell carcinoma of the head and neck
Keywords: IGF-1R; IGFBP-3; Squamous cell carcinoma of the head and neck; Prognosis; Immunohistochemistry;
The controversial links among calorie restriction, SIRT1, and resveratrol
Keywords: Ac; acetate; AMPK; AMP-activated kinase; CAECs; coronary arterial endothelial cells; CR; calorie restriction; CSE; cigarette smoke extract; eNOS; endothelial nitric oxide synthase; EX-527; 6-chloro-2,3,4,9-tetrahydro-1-H-carbazole-1-carboxamide; Fâ; flu
Molecular cloning of IGF-1 and IGF-1 receptor and their expression pattern in the Chilean flounder (Paralichthys adspersus)
Keywords: IGF-1; IGF-1R; Notochord; Somites; Chilean flounder
Molecular and Cellular PharmacologyInterruption of mitochondrial complex IV activity and cytochrome c expression activated O2ââ-mediated cell survival in silibinin-treated human melanoma A375-S2 cells via IGF-1R-PI3K-Akt and IGF-1R-PLC γ-PKC
Keywords: Silibinin; Superoxide anion; Hydrogen peroxide; Mitochondrial complex IV; Cytochrome c; IGF-1R; A375-S2 cell;
Novel Therapeutic Targets in Non-small Cell Lung Cancer
Keywords: Non-small cell lung cancer; Molecular target; Mutation; EGFR; VEGF; VEGFR; KRAS; BRAF; PIK3CA; EML4-ALK; IGF-1R
Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways
Keywords: CREB; cAMP-response element-binding protein; DA; dopamine; DAT; dopamine transporter; DOPAC; 3,4-dihydroxyphenylacetic acid; ERK; extracellular signal-regulated kinase; GPER1; G protein-coupled estrogen receptor 1; GSK3β; glycogen synthase kinase 3β; HV
Imidazo[2,1-b]thiazoles: Multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases
Keywords: IGF-1R; EGFR; ErbB2; Kinase; Inhibitor; Imidazo[2,1-b]thiazoles
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase
Keywords: IGF-1R; IR; Proline; Isosteres; Pyrrolotriazine
Insulinlike growth factor receptor type 1 and type 2 are downregulated in the nitrofen-induced hypoplastic lung
Keywords: IGF-1R; IGF-2R; Nitrofen; Hypoplastic lung; Congenital diaphragmatic hernia
Rôle de la voie de l'IGF dans les cancers bronchiques
Keywords: Cancer du poumon; Inhibiteurs de la protéine kinase; IGF-1R; Les marques de tumeurs; Lung cancer; Protein kinase inhibitors; IGF-1R; Tumour markers;
SAR of PXR transactivation in benzimidazole-based IGF-1R kinase inhibitors
Keywords: PXR; Pregnane X receptor; SAR; PXR transactivation; Insulin-like Growth Factor 1 Receptor kinase; IGF-1R; CYP3A expression; Cytochrome P450
The intricate involvement of the Insulin-like growth factor receptor signaling in mild traumatic brain injury in mice
Keywords: mTBI; IGF-1R; Akt; ERK1/2; Spatial memory; Y-maze test
The HER3/ErbB3 receptor: A promising target in cancer drug therapy
Keywords: HER; human epidermal growth factor receptor; RTKs; receptor tyrosine kinases; EGFR; epidermal growth factor receptor; IGF-1R; insulin-like growth factor type 1 receptor; IGF; insulin-like growth factor; EGF; epidermal growth factor; TGF-α; transforming
Endometrial expression of leptin receptor and members of the growth hormone—Insulin-like growth factor system throughout the estrous cycle in heifers
Keywords: LEPR; IGF; IGF-1R; GHR; Uterus; Cow
Insulin-Like Growth Factor-1 Receptor Expression in Thymic Malignancies
Keywords: Thymoma; Thymic carcinoma; IGF-1R; EGFR; KIT; Immunohistochemistry; Tissue microarray
Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer
Keywords: Bevacizumab; BRAF; EGFR; IGF-1R; NRAS; PIK3CA; PIP3; PTEN; KRAS; VEGF
Development of cetuximab-resistant human nasopharyngeal carcinoma cell lines and mechanisms of drug resistance
Keywords: Cetuximab; Drug resistance; Nasopharyngeal carcinoma; Ras; IGF-1R; PTEN
Clinical Updates on EGFR/HER Targeted Agents in Early-Stage Breast Cancer
Keywords: IGF-1R; Lapatinib; Monoclonal antibody; Neratinib; Pertuzumab; T-DM1; Trastuzumab
Synthesis of aryl-heteroaryl ureas (AHUs) based on 4-aminoquinoline and their evaluation against the insulin-like growth factor receptor (IGF-1R)
Keywords: Quinoline; Naphthyridine; 2-Chloroquinoline; 2-Quinolone; IGF-1R; Diaryl urea; Aryl heteroaryl urea; Insulin like growth factor receptor; Kinase inhibition; Pharmacophore based virtual screening