The structure and allosteric regulation of glutamate dehydrogenase
Keywords: آلوستری; Glutamate dehydrogenase; Insulin; Allostery; Hyperinsulinism
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Exploring and exploiting allostery: Models, evolution, and drug targeting
Keywords: آلوستری; Allostery; Conformational changes; Protein; Regulation
Metalloregulatory proteins: Metal selectivity and allosteric switching
Keywords: آلوستری; Transition metals; Metal homeostasis; Allostery; Repressor; Energetics; Protein-DNA interactions;
The role of protein conformational fluctuations in allostery, function, and evolution
Keywords: آلوستری; Allostery; Protein functional adaptation; Spontaneous fluctuations; Protein energetics; COREX/BEST algorithm; Protein ensemble; Protein evolution;
A Tale of Two Repressors
Keywords: آلوستری; operon; repressors; allostery; cooperativity; gene regulationNTD, N-terminal domain; CTD, carboxy-terminal domain; HTH, helix–turn–helix; CAP, catabolite activator protein
The scientific legacy of Jacques Monod
Keywords: آلوستری; Allostery; Unification, Model; Physics; Genetic regulatory mechanisms; Lysenkoism;
Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation
Keywords: آلوستری; sGC; YC-1; BAY; GTP; Allostery; Activation
Jacques Monod, 1910–1976: his life, his work and his commitments
Keywords: آلوستری; Monod Jacques; Nobel prize; Molecular biology; Regulation; Allostery
Flavonoid binding to human serum albumin
Keywords: آلوستری; FA, Fatty acid; HSA, Human serum albuminHuman serum albumin; Flavonoid binding; Daidzein; Daidzein metabolites; Genistein; Naringenin; Quercetin; Oleate; Thermodynamics; Allostery
Kinetic evidence that allosteric activation of antithrombin by heparin is mediated by two sequential conformational changes
Keywords: آلوستری; Heparin; Antithrombin; Serpin; Blood clotting; Protease; Allostery
Mre11–Rad50–Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks
Keywords: آلوستری; Crystal structures; Allostery; ATPase; Nuclease; FHA domain; BRCT domains
Synthesis and biological activity of conformationally restricted gypsy moth pheromone mimics
Keywords: آلوستری; Insect pheromone; Conformation; Ether; Electroantennogram; Agonist; Screen; Allostery; Library
Structural and functional bases for allosteric control of MMP activities: Can it pave the path for selective inhibition?
Keywords: آلوستری; Allostery; Allosteric regulation; Matrix metalloproteinase (MMP); Protein flexibility/hemopexin domain; Fibronectin domain; Exosite; Protein conformation
Translocation by multi-subunit RNA polymerases
Keywords: آلوستری; RNAP; RNA polymerase; TEC; ternary elongation complex; TFII; transcription factor RNA polymerase II; BH; bridge helix; TH; trigger helices; TL; trigger loop; FL2; fork loop 2; P; pre-insertion site; A; insertion site; RNA polymerase; Elongation; Transloca
Aspergillus terreus NADP-glutamate dehydrogenase is kinetically distinct from the allosteric enzyme of other Aspergilli
Keywords: آلوستری; Allostery; Aspergillus terreus; NADP-glutamate dehydrogenase; 2-oxoglutarate saturation
Kinetic study of von Willebrand factor self-aggregation induced by ristocetin
Keywords: آلوستری; Protein aggregation; Ristocetin; vonWillebrand factor; Light scattering; Primary haemostasis; Allostery;
Switching of the Bacterial Flagellar Motor Near Zero Load
Keywords: آلوستری; CW, clockwise; CCW, counterclockwiseEscherichia coli; nano-gold; torque; speed; allostery
The pH dependence of the allosteric response of human liver pyruvate kinase to fructose-1,6-bisphosphate, ATP, and alanine
Keywords: آلوستری; Pyruvate kinase; Liver form; Allosteric coupling; Allostery; pH dependence
Hemoglobin, an “evergreen” red protein
Keywords: آلوستری; CD, circular dichroism; Hb, hemoglobin; IHP, inositol hexaphosphate; MEM, maximum entropy method; MWC, Monod, Wyman and Changeux; PEG, polyethylene glycol; TTS, Tertiary Two State allosteric modelHemoglobin; Oxygen binding; Allostery; Microspectrophotomet
Ligand-induced ErbB receptor dimerization
Keywords: آلوستری; Epidermal growth factor receptor; Receptor tyrosine kinase; ErbB receptor; Cooperativity; Receptor dimerization; Crystal structure; Heterodimer; Autoinhibition; Ligand binding; Allostery
Oligomeric interactions provide alternatives to direct steric modes of control of sugar kinase/actin/hsp70 superfamily functions by heterotropic allosteric effectors: Inhibition of E. coli glycerol kinase
Keywords: آلوستری; Allostery; Linked-functions; Enzyme kinetics; Forster resonance energy transfer;
One Is Not Enough
Keywords: آلوستری; MWC model, Monod–Wyman–Changeux model; GFP, green fluorescent proteinlac repressor; allostery; induction; repression; inducer binding
Analysis of Insulin Allostery in Solution and Solid State With FTIR
Keywords: آلوستری; proteins; insulin; allostery; Fourier transform infrared (FTIR) spectroscopy; lyophilisation; protein structure; principal component analysis (PCA)
Minimal models of multi-site ligand-binding kinetics
Keywords: آلوستری; Allostery; Ligand; Saturation curve; Haemoglobin; Co-operative binding; Henri kinetics; Conformational kinetics
The Crystal Structure of UMP Kinase from Bacillus anthracis (BA1797) Reveals an Allosteric Nucleotide-Binding Site
Keywords: آلوستری; UMP, uridine monophosphate; UK, UMP kinase; NMP, nucleoside monophosphate kinase; UTP, uridine triphosphate; GTP, guanosine triphosphate; MAD, multiwavelength anomalous dispersion; PDB, Protein Data Bankuridylate kinase; pyrH; allostery; regulation; Gram-
Kinetics of electron transfer in the complex of cytochrome P450 3A4 with the flavin domain of cytochrome P450BM-3 as evidence of functional heterogeneity of the heme protein
Keywords: آلوستری; Cytochrome P450 3A4; Cytochrome P450BM-3 flavin domain (BMR); Electron transfer kinetics; Heterogeneity; Spin equilibrium; Allostery; Testosterone; 1-Pyrenebutanol; Bromocriptine; α-Naphthoflavone
Effect of glutathione on homo- and heterotropic cooperativity in cytochrome P450 3A4
Keywords: آلوستری; Cytochrome P450 3A4; Glutathione; Regulatory effect; Allostery; Human liver microsomes; 7-Benzyloxy-4-(trifluoromethyl)coumarin; 7-Benzyloxyquinoline; Testosterone; 1-Pyrenebutanol; α-Naphthoflavone
Protein dynamics explain the allosteric behaviors of hemoglobin
Keywords: آلوستری; Hb, hemoglobin; MD, molecular dynamics; BPG, 2,3-biphosphoglycerate; MWC, Monod, Wyman and Changeux; KNF, Koshland, Nemethy and FilmerHemoglobin (Hb); Oxygen-binding; Allostery; Cooperativity; Quaternary structure; Molecular dynamics
Tet Repressor Induction by Tetracycline: A Molecular Dynamics, Continuum Electrostatics, and Crystallographic Study
Keywords: آلوستری; TetR, Tet repressor; Tc, tetracycline; DBD, DNA-binding domain; MD, molecular dynamics; anTc, anhydrotetracyclineprotein; allostery; computer simulation; binding free energy; gene regulation
Amino acid biosynthesis: New architectures in allosteric enzymes
Keywords: آلوستری; ACT domain; Acetohydroxyacid synthase; Allosteric control; Allostery; Amino acid; Aspartate kinase; Metabolism; Dihydrodipicolinate synthase; Enzyme; Homoserine dehydrogenase; Isopropylmalate synthase; Plant structural biology; S-adenosylmethionine; Threo
Thrombin
Keywords: آلوستری; Thrombin; Allostery; Na+ activation; PARs
Mechanism of Na+ binding to thrombin resolved by ultra-rapid kinetics
Keywords: آلوستری; Thrombin; Sodium; Rapid kinetics; Allostery; Monovalent cation activation;
Crystal structure of thrombin in complex with fibrinogen γⲠpeptide
Keywords: آلوستری; Thrombin; Fibrinogen; γⲠpeptide; Serine protease structure; Allostery;
Allosteric properties of G protein-coupled receptor oligomers
Keywords: آلوستری; GPCR; Dimerization; Allostery; Binding cooperativity;
Genetic diversity of coastal bottlenose dolphins revealed by structurally and functionally diverse hemoglobins
Keywords: آلوستری; Hb A0; adult human hemoglobin; DPG; 2,3-diphosphoglycerate; IHP; inositol hexaphosphate; EDTA; ethylenediaminetetracetic acidPopulation diversity; Alleles; Oxygen binding; Allostery; Redox chemistry
Structural Analysis of Lac Repressor Bound to Allosteric Effectors
Keywords: آلوستری; Lac repressor; effector binding; allostery; inducer; conformational changeHTH, helix-turn-helix; IPTG, 1-isopropyl-β-d-thiogalactoside; ONPF, orthonitrophenyl-β-d-fucoside; ONPG, orthonitrophenyl-1-β-d-galactoside
Role of subunit interactions in P450 oligomers in the loss of homotropic cooperativity in the cytochrome P450 3A4 mutant L211F/D214E/F304W
Keywords: آلوستری; Cytochrome P450 3A4; Allostery; Cooperativity; Substrate binding; Oligomers; Spin equilibrium; Apoprotein; 1-Pyrenebutanol; Bromocryptine
An Allosteric Rheostat in HIV-1 gp120 Reduces CCR5 Stoichiometry Required for Membrane Fusion and Overcomes Diverse Entry Limitations
Keywords: آلوستری; HIV-1, human immunodeficiency virus type 1; 3SC, three-stranded coil; 6HB, six-helix bundle; SMCA, small molecule CCR5 antagonist; HA, hemagglutininhuman immunodeficiency virus; membrane fusion; allostery; CCR5; viral adaptation
Allosteric activation of antithrombin is independent of charge neutralization or reversal in the heparin binding site
Keywords: آلوستری; AT; antithrombin; RCL; reactive center loop; fXa; factor Xa; fIXa; factor IXa; H5; pentasaccharide; SI; stoichiometry of inhibition; Serpin; Protease; Allostery; Hemostasis; Thrombosis;
Physostigmine modulation of acetylcholine currents in COS cells transfected with mouse muscle nicotinic receptor
Keywords: آلوستری; Nicotinic ACh receptor; Eserine; Desensitization; Allostery;
Inhibitors of factor VIIa affect the interface between the protease domain and tissue factor
Keywords: آلوستری; Factor VIIa; Tissue factor; Fluorescent probe; Protein–protein interaction; Active site inhibitor; Exosite inhibitor; Allostery
High resolution crystal structures of free thrombin in the presence of K+ reveal the molecular basis of monovalent cation selectivity and an inactive slow form
Keywords: آلوستری; Thrombin; Allostery; Monovalent cation activated enzyme; Serine protease structure;
Modulation of effector affinity by hinge region mutations also modulates switching activity in an engineered allosteric TEM1 β-lactamase switch
Keywords: آلوستری; β-lactamase; Maltose-binding protein; Allostery; Switch;
A Mutation in the S-switch Region of the Runt Domain Alters the Dynamics of an Allosteric Network Responsible for CBFβ Regulation
Keywords: آلوستری; CBF, core binding factor; aa, amino acid residues; HA, high affinity core site; MLV, Moloney murine leukemia virus enhancer; NOE, nuclear Overhauser effectRUNX; AML1; CBFβ; allostery; NMR
The Na+ binding channel of human coagulation proteases: Novel insights on the structure and allosteric modulation revealed by molecular surface analysis
Keywords: آلوستری; Allostery; Na+ binding; Molecular modeling; Thrombin; Coagulation factors; Serine proteases;
Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation
Keywords: آلوستری; Hsp90 inhibitor; C-terminal domain; Small molecule probes; Allostery; In silico modeling; Prostate cancer therapeutic;
Dynamics of Allostery in Hemoglobin: Roles of the Penultimate Tyrosine H bonds
Keywords: آلوستری; hemoglobin; site mutants; tyrosine H bonds; allostery; protein dynamicsHb, hemoglobin; RR, resonance Raman; UVRR, resonance Raman spectroscopy with UV excitation; rHb, recombinant Hb
Heme impairs allosterically drug binding to human serum albumin Sudlow's site I
Keywords: آلوستری; Human serum albumin; Ferric heme-human serum albumin; Drugs; Ferric heme; Ligand binding; Allostery;
Structural and mutational studies of organophosphorus hydrolase reveal a cryptic and functional allosteric-binding site
Keywords: آلوستری; Phosphotriesterase; Allostery; Non-competitive inhibition; Chemical warfare agents; X-ray crystallography; Allosteric site; Competitive inhibition;
Dynamics of signaling by PKA
Keywords: آلوستری; cAMP; cyclic-3â², 5â²-adenosine monophosphate; PKA; cAMP-dependent protein kinase; PKI; heat stable protein kinase A inhibitor; PDK1; phosphoinositide-dependent kinase-1; ATP; adenosine triphosphate; ADP; adenosine diphosphate; D/D domain; dimerization/