دانلود مقالات ISI درباره بیماری آلزایمر + ترجمه فارسی

Melatonin ameliorates amygdala-dependent emotional memory deficits in Tg2576 mice by up-regulating the CREB/c-Fos pathway

Keywords: بیماری آلزایمر; Alzheimer's disease; Melatonin; Emotional memory; Basolateral amygdala; c-Fos;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleSynergistic effect of tanshinone IIA and mesenchymal stem cells on preventing learning and memory deficits via anti-apoptosis, attenuating tau phosphorylation and enhancing the activity of central cholinergic system in vascular dementia

Keywords: بیماری آلزایمر; VaD; vascular dementia; MSCs; mesenchymal stem cells; 4-VO; four-vessel occlusion; TSA; tanshinone II A; AD; Alzheimer's disease; MWM; morris water maze; GSK 3β; glycogen synthase kinase 3β; ACh; acetylcholine; ChAT; choline acetyltransferase; AChE; a

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of β2-adrenergic receptor promotes dendrite ramification and spine generation in APP/PS1 mice

Keywords: بیماری آلزایمر; Alzheimer's disease; β2-adrenoceptors; Amyloid β; Dendrite ramification; Spine generation; Clenbuterol;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleFormononetin attenuates Aβ25-35-induced cytotoxicity in HT22 cells via PI3K/Akt signaling and non-amyloidogenic cleavage of APP

Keywords: بیماری آلزایمر; amyloid β; Aβ; Alzheimer's disease; AD; estrogen receptor α; ERα; formononetin; Form; soluble amyloid precursor protein α; sAPPα; Alzheimer's disease; β-amyloid; Formononetin; APP; ERα; PI3K/Akt;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Acquisition and reversal of visual discrimination learning in APPSwDI/Nos2−/− (CVN) mice

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; APP; amyloid precursor protein; CT; correction trial; CVN mice; APPSwDI/Nos2−/− mice; ITI; inter-trial interval; PI; perseveration index; RM ANOVA; repeated measures analysis of variance; WT; wild type; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Physiological and pathological functions of neuroserpin: Regulation of cellular responses through multiple mechanisms

Keywords: بیماری آلزایمر; Protease inhibitor; Tissue plasminogen activator; Synaptic plasticity; Neuroprotection; Alzheimer's disease; Brain cancer;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Increased susceptibility to Aβ toxicity in neuronal cultures derived from familial Alzheimer's disease (PSEN1-A246E) induced pluripotent stem cells

Keywords: بیماری آلزایمر; Alzheimer's disease; Induced pluripotent stem cells; Amyloid-beta; Neurotoxicity;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Archival ReportMultimodal Brain Imaging Reveals Structural Differences in Alzheimer's Disease Polygenic Risk Carriers: A Study in Healthy Young Adults

Keywords: بیماری آلزایمر; Alzheimer's disease; Cingulum; Fornix; Hippocampus; Imaging; Polygenic risk;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Predicting with Confidence: Classifiers that Know What They Don't Know

Keywords: بیماری آلزایمر; estimating prediction error; GRNN oracle; Alzheimer's disease; speech patterns; t-SNE algorithm; learning classifier systems;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Colorimetric sandwich immunosensor for Aβ(1-42) based on dual antibody-modified gold nanoparticles

Keywords: بیماری آلزایمر; Alzheimer's disease; Gold nanoparticles; Colorimetric sandwich immunosensor; Aβ(1-42); Antibody;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Seizure susceptibility in the APP/PS1 mouse model of Alzheimer's disease and relationship with amyloid β plaques

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; DSP4; N-(2-chloroethyl)-N-ethylbromo-benzylamine; GABA; γ-aminobutyric acid; PTZ; pentylenetetrazole; WT; wild-type; Epileptiform-like discharges; Aβ plaques; EEG; Pentylenetetr

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prenatal high sucrose intake affected learning and memory of aged rat offspring with abnormal oxidative stress and NMDARs/Wnt signaling in the hippocampus

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; DKK1; Dickkopf-related protein 1; FINS; fasting plasma insulin; HS; high sucrose; FPG; fasting plasma glucose concentration; FZD; Frizzled; Homa-IR; insulin resistance index; LRP5/6; low-density lipoprotein-related protein recep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research reportMutant presenilin2 promotes apoptosis through the p53/miR-34a axis in neuronal cells

Keywords: بیماری آلزایمر; The p53/miR-34a axis; Alzheimer's disease; Presenilin 2; Apoptosis; Sirt1; Bcl-2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewAmylin and its G-protein-coupled receptor: A probable pathological process and drug target for Alzheimer's disease

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; AmR; amylin receptor; Aβ; amyloid-β peptide; BBB; blood-brain barrier; CGRP; calcitonin gene-related peptide; CTR; calcitonin receptor; GPCR; G-protein-coupled receptor; IDE; insulin-degrading enzyme; LRP1; lipoprotein recep

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleNF-κB dependent up-regulation of TRPC6 by Aβ in BV-2 microglia cells increases COX-2 expression and contributes to hippocampus neuron damage

Keywords: بیماری آلزایمر; TRPC6; Aβ; BV-2 microglia; NF-κB; COX-2; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research articleChronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer's disease model mice

Keywords: بیماری آلزایمر; Sleep disturbance; Sleep fragmentation; Alzheimer's disease; Amyloid β; Neurodegenerative diseases;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Apolipoprotein E4 causes early olfactory network abnormalities and short-term olfactory memory impairments

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ANOVA; analysis of variance; ApoE; apolipoprotein E; ApoE3; apolipoprotein E3; ApoE4; apolipoprotein E4; FFT; Fast-Fourier transform; LPF; local field potentials; OB; olfactory bulb; OERP; olfactory event-related potential; PCX;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prophylactic active immunization with a novel epitope vaccine improves cognitive ability by decreasing amyloid plaques and neuroinflammation in APP/PS1 transgenic mice

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid-β peptide; Neuroinflammation; Gliosis; Epitope vaccine;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors

Keywords: بیماری آلزایمر; MARK; Kinase; Tau; Alzheimer's disease; Pyrrolopyrimidinone;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Effect of vitamin E on 24(S)-hydroxycholesterol-induced necroptosis-like cell death and apoptosis

Keywords: بیماری آلزایمر; ACAT1; acyl-CoA:cholesterol acyltransferase 1; AD; Alzheimer's disease; PD; Parkinson's disease; 24S-OHC; 24(S)-Hydroxycholesterol; atRA; all-trans-retinoic acid; α-Toc; α-tocopherol; α-Toc3; α-tocotrienol; CumOOH; cumene hydroperoxide; LD; lipid

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Invited ReviewDoes B lymphocyte-mediated autoimmunity contribute to post-stroke dementia?

Keywords: بیماری آلزایمر; Stroke; Dementia; Vascular dementia; Alzheimer's Disease; Autoimmune; Autoantibody; Lymphocyte;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Regional correlations between [11C]PIB PET and post-mortem burden of amyloid-beta pathology in a diverse neuropathological cohort

Keywords: بیماری آلزایمر; Imaging; Pathology; Amyloid; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Development and comprehensive comparison of two on-line capillary electrophoretic methods for β-secretase inhibitor screening

Keywords: بیماری آلزایمر; Alzheimer's disease; β-secretase; Capillary electrophoresis; Electrophoretically mediated microanalysis; Inhibition; Kinetics; Transverse diffusion of laminar flow profiles; Validation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease

Keywords: بیماری آلزایمر; Arterial spin labeling; Magnetic resonance imaging; Cerebral blood flow; Aging; Mild cognitive impairment; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

TFP5 is comparable to mild hypothermia in improving neurological outcomes in early-stage ischemic stroke of adult rats

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; BBB; blood-brain barrier; CDK5; cyclin-dependent kinase 5; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; IHC; immunohistochemistry; MAP; mean artery pressure; MCAO; middle cerebral artery occlusion; MH; mild hypothermia; MM

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Resveratrol ameliorates spatial learning memory impairment induced by Aβ1-42 in rats

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ANOVA; analysis of variance; Aβ; β-amyloid peptide; BDNF; brain-derived neurotrophic factor; CREB; cAMP response binding protein; fEPSP; field excitatory postsynaptic potential; HFS; high-frequency stimulation; LTP; long-term

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Cerebrospinal fluid neurofilament light chain as a biomarker of neurodegeneration in the Tg4510 and MitoPark mouse models

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; CSF; cerebrospinal fluid; DAT; dopamine transporter; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol-bis(β-aminoethyl ether)-N,N,N′,N′-tetraacetic acid; NF-L; neurofilament light; NFs; neurofilaments; PD; Parki

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Early postnatal handling reduces hippocampal amyloid plaque formation and enhances cognitive performance in APPswe/PS1dE9 mice at middle age

Keywords: بیماری آلزایمر; Early handling; Alzheimer's disease; Cognitive reserve; Stress; Enrichment;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Lithium and memantine improve spatial memory impairment and neuroinflammation induced by β-amyloid 1-42 oligomers in rats

Keywords: بیماری آلزایمر; Alzheimer's disease; Dementia; β-Amyloid 1-42; Lithium; Memantine; Spatial memory; Cytokines;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Research reportButyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18FDG retention in 5XFAD mouse model of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Positron emission tomography (PET); 18FDG; β-Amyloid; Butyrylcholinesterase (BChE); 5XFAD mouse;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Neural changes in Alzheimer's disease from circuit to molecule: Perspective of optogenetics

Keywords: بیماری آلزایمر; Alzheimer's disease; Optogenetics; Neural circuits; Synapse; Molecular pathway; Learning; Memory;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Phyllanthus emblica L. (Indian gooseberry) extracts protect against retinal degeneration in a mouse model of amyloid beta-induced Alzheimer's disease

Keywords: بیماری آلزایمر; Indian gooseberry; Retinal degeneration; Alzheimer's disease; Amyloid beta;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

A metabolic profiling approach to an Italian sage leaf extract (SoA541) defines its antioxidant and anti-acetylcholinesterase properties

Keywords: بیماری آلزایمر; LC-MS/MS; liquid chromatography mass/mass spectrometry; CNS; central nervous system; AD; Alzheimer's Disease; AChE; acetylcholinesterase; AChEI; acetylcholinesterase inhibitors; UAM; ultrasound assisted maceration; LLE; liquid liquid extraction; Q; quer

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Priority Communication12/15-Lipoxygenase Inhibition Reverses Cognitive Impairment, Brain Amyloidosis, and Tau Pathology by Stimulating Autophagy in Aged Triple Transgenic Mice

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid beta; Animal model; Autophagy; Tau protein; 12/15-Lipoxygenase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Disclosing genetic risk of Alzheimer's disease to cognitively impaired patients and visit companions: Findings from the REVEAL Study

Keywords: بیماری آلزایمر; Alzheimer's disease; Cognitive impairment; Genetic testing; Genetic counseling; Patient-provider communication; Patient-centeredness; Visit companion;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

5-Substituted 2-benzylidene-1-tetralone analogues as A1 and/or A2A antagonists for the potential treatment of neurological conditions

Keywords: بیماری آلزایمر; Parkinson's disease; Alzheimer's disease; 5-Hydroxy-2-benzylidene-1-tetralones; A1 adenosine receptor antagonists; A2A adenosine receptor antagonists;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

An UHPLC-MS/MS method for simultaneous quantification of human amyloid beta peptides Aβ1-38, Aβ1-40 and Aβ1-42 in cerebrospinal fluid using micro-elution solid phase extraction

Keywords: بیماری آلزایمر; Alzheimer's disease; Amyloid β Peptide; UHPLC-MS/MS; Simultaneous quantification; Human cerebrospinal fluid;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation on brain gray matter activity and white matter integrity by APOE ε4 risk gene in cognitively intact elderly: A multimodal neuroimaging study

Keywords: بیماری آلزایمر; Gray matter activity; White matter integrity; APOE ε4; Cognitively intact elderly; fMRI; MRI; DTI; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Chitinase1 contributed to a potential protection via microglia polarization and Aβ oligomer reduction in D-galactose and aluminum-induced rat model with cognitive impairments

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; ANOVA; analysis of variance; Aβ; β-amyloid; qRT-PCR; quantitative reverse transcription-polymerase chain reaction; SD; standard deviation; Alzheimer's disease; chitinase1; microglia; β-amyloid oligomers; neuroprotection;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Time-course of glial changes in the hyperhomocysteinemia model of vascular cognitive impairment and dementia (VCID)

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; AQP4; aquaporin 4 water channel; CAA; cerebral amyloid angiopathy; HHcy; hyperhomocysteinemia; MMP9; Matrix metalloproteinase 9; VCID; vascular cognitive impairment and dementia; neuroinflammation; astrocyte; dementia; cerebrova

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewLong non-coding RNAs in brain development, synaptic biology, and Alzheimer's disease

Keywords: بیماری آلزایمر; Long non-coding RNA; Alzheimer's disease; Neurodevelopment; Synaptic plasticity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Research reportA novel dual GLP-1/GIP receptor agonist alleviates cognitive decline by re-sensitizing insulin signaling in the Alzheimer icv. STZ rat model

Keywords: بیماری آلزایمر; Alzheimer's disease; Incretin; Insulin signaling; Apoptosis; Inflammation; Tau phosphorylation; Type 2 diabetes mellitus;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Riluzole ameliorates learning and memory deficits in Aβ25-35-induced rat model of Alzheimer's disease and is independent of cholinoceptor activation

Keywords: بیماری آلزایمر; Riluzole; Alzheimer's disease; Aβ25-35; Learning and memory; Oxidative stress; Cholinergic receptor; Acetylcholinesterase;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer's disease

Keywords: بیماری آلزایمر; AChE; acetylcholinesterase; AChEI; acetylcholinesterase inhibitor; AD; Alzheimer's disease; ALP; alkaline phosphatase; ALT; alanine transferase; AOPP; advanced protein oxidation products; AST; aspartate transaminase; AU; arbitrary unit; COPD; chronic ob

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Original articleAnti-inflammatory role of Leptin in glial cells through p38 MAPK pathway inhibition

Keywords: بیماری آلزایمر; AD; alzheimer's disease; AMPK; AMP-activated protein kinase; ATF; ATP protein fusion; BBB; brain blood barrier; CNS; central nervous system; CYT; cytokines; Cyt-c; cytochrome c; IFNγ; interferon-gamma; IL1β; interleukin 1-beta; iNOS; inducible nitric

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular pathophysiology of impaired glucose metabolism, mitochondrial dysfunction, and oxidative DNA damage in Alzheimer's disease brain

Keywords: بیماری آلزایمر; Alzheimer's disease; Glucose metabolism; Mitochondrial dysfunction; Oxidative DNA damage; 8-Oxoguanine;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Beta-amyloid oligomers; Memory impairment; Novel object recognition test; Neuroinflammation; Pro-inflammatory cytokines; IL-1β; IL-1β receptor antagonist; Indomethacin; Toll-like receptor 4;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer's disease

Keywords: بیماری آلزایمر; Alzheimer's disease; Aβ aggregation; Inhibitors; Structure-activity relationship; Indole derivatives; Azaindole derivatives;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose binds to the N-terminal metal binding region to inhibit amyloid β-protein oligomer and fibril formation

Keywords: بیماری آلزایمر; AD; Alzheimer's disease; Aβ; amyloid β-protein; Aβ1-11; amyloid β-protein (1-11); Aβ11-22; amyloid β-protein (11-22); Aβ12-22; amyloid β-protein (12-22); Aβ25-35; amyloid β-protein (25-35); Aβ36-42; amyloid β-protein (36-42); Aβ1-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Rebamipide reduces amyloid-β 1-42 (Aβ42) production and ameliorates Aβ43-lowered cell viability in cultured SH-SY5Y human neuroblastoma cells

Keywords: بیماری آلزایمر; Aβ; amyloid-beta; AD; Alzheimer's disease; ADAM; a disintegrin and metalloproteinase; APP; amyloid precursor protein; ASPD; amylospheroids; BCA; bicinchoninic acid; BACE1; β-site APP-cleaving enzyme-1; BDNF; brain-derived neurotrophic factor; BSA; bov

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه