Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Triple-transgenic AD (3xTg-AD) mice; Circadian rhythm; Locomotor activity; Per1; Per2;
مقالات ISI بیماری آلزایمر (AD) (ترجمه نشده)
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Keywords: بیماری آلزایمر (AD); Magnetic resonance imaging (MRI) data; Structural measurements; Neighborhood component analysis (NCA); Ensemble decision tree; Boosting; Cross validation; Alzheimer's disease (AD); Mild cognitive impairment (MCI);
Keywords: بیماری آلزایمر (AD); 5-HT; 5-hydroxytryptamine; AA; arachidonic acid; ACh; acetylcholine; ACTH; adrenocorticotrophic hormone; AD; Alzheimer's Disease; ADP; adenosine diphosphate; Aβ; amyloid β; AMP; adenosine monophosphate; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepro
Keywords: بیماری آلزایمر (AD); Concrete words; Abstract words; Semantic memory; Conceptual knowledge; Semantic variant primary progressive aphasia (svPPA); Alzheimer's disease (AD);
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Electroencephalography (EEG); Portable; Low-density; Amplitude modulation; Spectral power; Coherence; Diagnosis;
Keywords: بیماری آلزایمر (AD); discrete-choice experiment (DCE); Alzheimer's disease (AD); diagnostic test information; money-equivalent value (MEV);
Keywords: بیماری آلزایمر (AD); Contrast sensitivity (CS); Frequency doubling technology (FDT); Alzheimer's disease (AD); Mild cognitive impairment (MCI); Cognitive complaints; Biomarker; Vision;
Synthesis of carbon-11-labeled CK1 inhibitors as new potential PET radiotracers for imaging of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Casein kinase 1 (CK1); Carbon-11-labeled CK1 inhibitors; Radiosynthesis; Positron emission tomography (PET); Alzheimer's disease (AD);
Diastereoselective synthesis of fused cyclopropyl-3-amino-2,4-oxazine β-amyloid cleaving enzyme (BACE) inhibitors and their biological evaluation
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); BACE inhibitor; β-Secretase; Oxazine; Structure-based design;
AMPK induced memory improvements in the diabetic population: A case study
Keywords: بیماری آلزایمر (AD); Type 2 diabetes (T2D); Alzheimer's disease (AD); Mild cognitive impairment (MCI); Ketogenic diet; High intensity interval training (HIIT); AMPK; mTOR;
Synthesis of carbon-11-labeled 5-HT6R antagonists as new candidate PET radioligands for imaging of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Serotonin (5-hydroxytryptamine) 6 receptor (5-HT6R); Carbon-11-labeled 5-HT6R antagonists; Radiosynthesis; Positron emission tomography (PET); Alzheimer's disease (AD);
Glia-specific APOE epigenetic changes in the Alzheimer's disease brain
Keywords: بیماری آلزایمر (AD); Apolipoprotein E (APOE); Alzheimer's disease (AD); DNA methylation; Epigenetics; Fluorescence-activated nuclei sorting (FANS); Glia; 7AAD; 7-Aminoactinomycin D; ACTB; actin beta; AD; Alzheimer's disease; AIF1; allograft inflammatory factor 1; APOE; ap
Explore the effects of Huang-Lian-Jie-Du-Tang on Alzheimer's disease by UPLC-QTOF/MS-based plasma metabolomics study
Keywords: بیماری آلزایمر (AD); Huang-Lian-Jie-Du-Tang (HLJDT); Alzheimer's disease (AD); Metabolomics; Potential biomarkers; Anti-neuroinflammation;
NAD-biosynthetic enzyme NMNAT1 reduces early behavioral impairment in the htau mouse model of tauopathy
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); htau; NMNAT1; NAD; Food burrowing; MRS;
Insulin-signaling Pathway Regulates the Degradation of Amyloid β-protein via Astrocytes
Keywords: بیماری آلزایمر (AD); ACE; angiotensin-converting enzyme; AD; Alzheimer's disease; AÃ; amyloid Ã-protein; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; ECE; endothelin-converting enzyme; EDTA; ethylenediaminetetraacetic acid; EGCG; epigallocatechi
The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
Keywords: بیماری آلزایمر (AD); Low-density lipoprotein receptor-related protein 1 (LRP1); ABC transporter B1/P-glycoprotein (ABCB1/P-gp); Phosphatidylinositol-binding clathrin assembly protein (PICALM); Amyloid-beta (Aβ); Blood-brain barrier (BBB); Transcytosis; Alzheimer's disease
Running for REST: Physical activity attenuates neuroinflammation in the hippocampus of aged mice
Keywords: بیماری آلزایمر (AD); AD; Alzheimer's disease (AD); BDNF; brain-derived neurotrophic factor; IL; interleukin; NRSF; neuron-restrictive silencer factor; REST; RE1-binding transcription factor; RW; running wheel; SED; sedentary; TST; tail suspension test; Aging; BDNF; Exercise
Maternal separation exacerbates Alzheimer's disease-like behavioral and pathological changes in adult APPswe/PS1dE9 mice
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Maternal separation(MS); Senile plaque; Cholinergic neuron;
Synthesis of carbon-11-labeled isonicotinamides as new potential PET agents for imaging of GSK-3 enzyme in Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Carbon-11-labeled isonicotinamides; Glycogen synthase kinase-3 (GSK-3); Radiosynthesis; Positron emission tomography (PET); Alzheimer's disease (AD);
Predicting conversion from MCI to AD using resting-state fMRI, graph theoretical approach and SVM
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Mild cognitive impairment (MCI); MCI converter; MCI non-converter; Resting-state fMRI; Graph theory; Machine learning approach;
Meta-analysis of expression and function of neprilysin in Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Neprilysin (NEP); Metalloendopeptidase; Alzheimer's disease (AD); Meta-analysis;
Classification of patients with MCI and AD from healthy controls using directed graph measures of resting-state fMRI
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Mild cognitive impairment (MCI); Resting-state fMRI; Granger causality analysis; Graph theoretical approach; Machine learning approach;
Research reportAn aberrant link between gamma oscillation and functional connectivity in Aβ1-42-mediated memory deficits in rats
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Working memory; Gamma oscillation; Functional connectivity; Rat; Local field potentials (LFP);
Clec4g (LSECtin) interacts with BACE1 and suppresses Aβ generation
Keywords: بیماری آلزایمر (AD); AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; β-site amyloid precursor protein cleaving enzyme-1; Clec4g; C-type lectin-like domain containing-4g; GlcNAc; N-acetylglucosamine; GnT-III; N-acetylglucosaminyltransferase-III; Alzheimer'
Synthesis of a PET tau tracer [11C]PBB3 for imaging of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); [11C]PBB3; Tau tracer; Radiosynthesis; Positron emission tomography (PET); Alzheimer's disease (AD);
Development of 2-aminooxazoline 3-azaxanthenes as orally efficacious β-secretase inhibitors for the potential treatment of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); β-Secretase (BACE1); Aminooxazoline; Xanthene; 3-Azaxanthene; Amyloid; Aβ peptides;
Co-morbid beta-amyloid toxicity and stroke produce impairments in an ambiguous context task in rats without any impairment in spatial working memory
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Stroke; Beta-amyloid; Discriminative fear-conditioning to context; Morris water task; Acetylcholine; Hippocampus; Cue ambiguity;
Identifying patients with Alzheimer's disease using resting-state fMRI and graph theory
Keywords: بیماری آلزایمر (AD); Resting-state functional magnetic resonance imaging (rs-fMRI); Alzheimer's disease (AD); Graph theory; Machine learning; Statistical analysis;
Concise and high-yield synthesis of T808 and T808P for radiosynthesis of [18F]-T808, a PET tau tracer for Alzheimer's disease
Keywords: بیماری آلزایمر (AD); [18F]-T808; Tau tracer; Automation; Positron emission tomography (PET); Alzheimer's disease (AD);
Synthesis of a new fluorine-18-labeled bexarotene analogue for PET imaging of retinoid X receptor
Keywords: بیماری آلزایمر (AD); 2-[18F]fluoro-4-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid; Bexarotene; Retinoid X receptor (RXR); Apolipoprotein E (APOE); Positron emission tomography (PET); Alzheimer's disease (AD); Cancer;
Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease
Keywords: بیماری آلزایمر (AD); Aβ; amyloid-beta; AD; Alzheimer's disease; BBB; blood-brain barrier; BSA; bovine serum albumin; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase; ICV; intracerebroventricularly; NFTs; neurofibrillary tangles; Nrf2; nuclear factor-E
The first synthesis of [11C]J147, a new potential PET agent for imaging of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); [11C]J147; Alzheimer's disease (AD); Radiosynthesis; Automation; Positron emission tomography (PET); Brain imaging;
Investigating the binding interactions of galantamine with β-amyloid peptide
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Cholinesterase inhibitors (ChEIs); Acetylcholinesterase (AChE); Butyrylcholinesterase (BuChE); Disease-modifying agents (DMA); Nuclear magnetic resonance (NMR); β-Amyloid peptide (Aβ); Molecular dynamics (MD); Root mean squar
Selective inhibition of human acetylcholinesterase by xanthine derivatives: In vitro inhibition and molecular modeling investigations
Keywords: بیماری آلزایمر (AD); Central nervous system (CNS); Alzheimer's disease (AD); Cholinesterase inhibitors (ChEIs); Acetylcholinesterase (AChE); Butyrylcholinesterase (BuChE); Acetylcholine (ACh); Peripheral anionic site (PAS);
Discovery of 2-methylpyridine-based biaryl amides as γ-secretase modulators for the treatment of Alzheimer's disease
Keywords: بیماری آلزایمر (AD); γ-Secretase modulator (GSM); γ-Secretase inhibitor (GSI); Alzheimer's disease (AD); Amyloid β-protein (Aβ); Methylpyridine; Amide as sulfonamide replacement;
Fluorescent 2-styrylpyridazin-3(2H)-one derivatives as probes targeting amyloid-beta plaques in Alzheimer's disease
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Amyloid plaque; Fluorescent probe; 2-Styrylpyridazin-3(2H)-one;
Aminoimidazoles as BACE-1 inhibitors: The challenge to achieve in vivo brain efficacy
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); β-Secretase; BACE-1 inhibitors; Aminoimidazoles; Efflux; In vivo brain efficacy;
Dual effects of curcumin on neuronal oxidative stress in the presence of Cu(II)
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Anti-oxidation; Copper; Curcumin; Oxidative stress; Pro-oxidation;
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2â² region
Keywords: بیماری آلزایمر (AD); AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d
CXCL8 protects human neurons from amyloid-β-induced neurotoxicity: Relevance to Alzheimer's disease
Keywords: بیماری آلزایمر (AD); MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; DAPI; 4â²,6-diamidino-2-phenylindole; AD; Alzheimer's disease; Aβ; amyloid-β; BDNF; brain-derived neurotrophic factor; CNND; Center for Neurovirology and Neurodegenerative Disorders;
Substrate-specific reduction of PP2A activity exaggerates tau pathology
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); Frontotemporal dementia (FTD); Kinase; Microtubule; Neurofibrillary tangle (NFT); Phosphatase; Tau;
Alzheimer's Treatment in Nursing Homes: Room for Improvement
Keywords: بیماری آلزایمر (AD); Alzheimer's disease (AD); nursing home; acetylcholinesterase inhibitors (cholinesterase inhibitors); long-term care;