Keywords: ضدعفونی کننده; Plasmodium knowlesi; Malaria; dhfr-ts; Antifolate;
مقالات ISI ضدعفونی کننده (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Keywords: ضدعفونی کننده; Nuclear thymidylate synthesis; Antifolate; Folate-mediated one-carbon metabolism; Sumoylation; Thymidylate synthase;
Keywords: ضدعفونی کننده; Antifolate; DHFR; Protein flexibility; X-ray crystallography; Molecular dynamics;
Rational design and microwave assisted synthesis of some novel phenyl thiazolyl clubbed s-triazine derivatives as antimalarial antifolate
Keywords: ضدعفونی کننده; Antifolate; Antimalarial; Docking; Phenylthiazole;
Synthesis and antiproliferative activity of a series of novel 6-substituted pyrido[3,2-d]pyrimidines as potential nonclassical lipophilic antifolates targeting dihydrofolate reductase
Keywords: ضدعفونی کننده; Pyrido[3,2-d]pyrimidines; Antifolate; Dihydrofolate reductase inhibitor; Anticancer; VUPHQOYNMYZUIQ-TWTCKAASSA-N;
Pterin–sulfa conjugates as dihydropteroate synthase inhibitors and antibacterial agents
Keywords: ضدعفونی کننده; Sulfonamide; Antibiotics; Antifolate; Dihydropteroate synthase; Pterin
Néphrotoxicité du pemetrexed
Keywords: ضدعفونی کننده; Pemetrexed; Antifolate; Insuffisance rénale; Diabète insipide néphrogénique; Pemetrexed; Antifolate; Renal failure; Nephrogenic diabetes insipidus;
Therapeutic options in relapsed or refractory peripheral T-cell lymphoma
Keywords: ضدعفونی کننده; Peripheral T-cell lymphoma; Histone deacetylase inhibitor; Antifolate; Nucleoside analog; Fusion protein; Immunomodulatory agent;
Folate metabolism in human malaria parasites—75 years on
Keywords: ضدعفونی کننده; Antifolate; De novo folate synthesis; Drug resistance; Drug targeting; Folate salvage; Intermittent preventative treatment (IPT)
Pralatrexate Is an Effective Treatment for Relapsed or Refractory Transformed Mycosis Fungoides: A Subgroup Efficacy Analysis From the PROPEL Study
Keywords: ضدعفونی کننده; Antifolate; Efficacy; Relapsed; Refractory peripheral T-cell lymphoma; Safety; Transformed mycosis fungoides
Antimalarial evaluation and docking studies of hybrid phenylthiazolyl-1,3,5-triazine derivatives: A novel and potential antifolate lead for Pf-DHFR-TS inhibition
Keywords: ضدعفونی کننده; 1,3,5-Triazine; Docking; Antimalarial; Antifolate;
The crystal structure of Leishmania major N5,N10-methylenetetrahydrofolate dehydrogenase/cyclohydrolase and assessment of a potential drug target
Keywords: ضدعفونی کننده; Antifolate; Cyclohydrolase; Dehydrogenase; Drug target; Leishmania; Trypanosoma;
Randomized Phase 2b Study of Pralatrexate Versus Erlotinib in Patients With Stage IIIB/IV Non–Small-Cell Lung Cancer (NSCLC) After Failure of Prior Platinum-Based Therapy
Keywords: ضدعفونی کننده; antifolate; non–small-cell lung cancer; pralatrexate; survival
Assessment of in vitro sensitivity of Plasmodium vivax fresh isolates
Keywords: ضدعفونی کننده; Plasmodium vivax; Chloroquine; In vitro sensitivity; Schizont maturation inhibition assay; SYBR Green-I assay; Fresh isolate; Antifolate; Malaria; Antimalarial drug; Standard regimen;
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
Keywords: ضدعفونی کننده; Pemetrexed; SHMT; Antifolate; Pleural mesotheliomaSHMT, serine hydroxymethyltransferase; THF, tetrahydrofolate; H4PteGlu, tetrahydropteroylglutamate; TS, thymidylate synthase; DHFR, dihydrofolate reductase; dTMP, 2′-deoxythymidine monophosphate
2,4-Diamino-5-(2′-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition
Keywords: ضدعفونی کننده; Antifolate; Dihydrofolate reductase; Human DHFR; Molecular modeling; Propargyl-linked antifolate
Pralatrexate with Vitamin Supplementation in Patients with Previously Treated, Advanced Non-small Cell Lung Cancer: Safety and Efficacy in a Phase 1 Trial
Keywords: ضدعفونی کننده; Pralatrexate; Antifolate; Non-small cell lung cancer; NSCLC; Dose-finding
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species
Keywords: ضدعفونی کننده; Plasmodium berghei; Plasmodium yoelii yoelii; Plasmodium chabaudi and Plasmodium vinckei; Methotrexate; Aminopterin; Antifolate; Folate receptor; Pyrimethamine
5,10-Methenyltetrahydrofolate synthetase activity is increased in tumors and modifies the efficacy of antipurine LY309887
Keywords: ضدعفونی کننده; Folate metabolism; Methenyltetrahydrofolate synthetase; Purine biosynthesis; LY309887; Antifolate; Glycinamide ribonucleotide formyltransferase
Inhibition of human folylpolyglutamate synthetase by diastereomeric phosphinic acid mimics of the tetrahedral intermediate
Keywords: ضدعفونی کننده; Folylpolyglutamate synthetase; Phosphapeptide inhibitor; Stereospecificity; Structure-activity relationship; Antifolate; Mechanism-based;
In vitro biological activity and structural analysis of 2,4-diamino-5-(2′-arylpropargyl)pyrimidine inhibitors of Candida albicans
Keywords: ضدعفونی کننده; Antifolate; Dihydrofolate reductase; Candida albicans; Molecular modeling
Functional identity of the active sites of crustacean and viral thymidylate synthases
Keywords: ضدعفونی کننده; Litopenaus vannamei; Shrimp; Prawn; Thymidylate synthase; White spot syndrome virus; Antifolate binding; Differential inhibition; Antifolate;
X-ray structure of the ternary MTX·NADPH complex of the anthrax dihydrofolate reductase: A pharmacophore for dual-site inhibitor design
Keywords: ضدعفونی کننده; DHFR; dihydrofolate reductase; ba; Bacillus anthracis; ec; Escherichia coli; hs; Homo sapiens; MTX; methotrexate; p-ABA; para-aminobenzoic acid; NADPH; nicotinamide adenine dinucleotide phosphate (reduced form); DHF; dihydrofolate; IC50; inhibitor concent
Metabolism-blocked antifolates as potential anti-rheumatoid arthritis agents: 4-Amino-4-deoxy-5,8,10-trideazapteroyl-d,l-4′-methyleneglutamic acid (CH-1504) and its analogs
Keywords: ضدعفونی کننده; Antifolate; Rheumatoid arthritis; CH-1504; Methotrexate; Drug metabolism; Structure–activity relationship
Phase II Trial of Pralatrexate (10-Propargyl-10-deazaaminopterin, PDX) in Patients with Unresectable Malignant Pleural Mesothelioma
Keywords: ضدعفونی کننده; Pralatrexate; 10-Propargyl-10-deazaaminopterin; PDX; Mesothelioma; Antifolate;
Pemetrexed Maintenance Therapy in Patients with Malignant Pleural Mesothelioma
Keywords: ضدعفونی کننده; Maintenance therapy; Malignant mesothelioma; Pemetrexed; Toxicity; Antifolate
The 3D-QSAR analysis of 4(3H)-quinazolinone derivatives with dithiocarbamate side chains on thymidylate synthase
Keywords: ضدعفونی کننده; Thymidylate synthase; Antifolate; FlexiDock; QSAR;
Plasmodium vivax dihydrofolate reductase point mutations from the Indian subcontinent
Keywords: ضدعفونی کننده; Malaria; Plasmodium vivax; Dihydrofolate reductase; Antifolate; Pyrimethamine; Point mutations; Drug resistance
Characterization of Human γ-glutamyl hydrolase in solution demonstrates that the enzyme is a non-dissociating homodimer
Keywords: ضدعفونی کننده; GH, γ-glutamyl hydrolase; hGH, human GH; HisTag hGH, hGH expressed as an N-terminal 6XHis fusion protein; glycosylated hGH, hGH expressed in insect cellsFolate metabolism; Antifolate; Polyglutamate; Glutamyl hydrolase; Homodimer
Why has the dihydrofolate reductase 164 mutation not consistently been found in Africa yet?
Keywords: ضدعفونی کننده; Malaria; Plasmodium falciparum; Dihydrofolate reductase; Drug resistance; Antifolate; Africa;
Identification of the optimal third generation antifolate against P. falciparum and P. vivax
Keywords: ضدعفونی کننده; Antifolate; Antimalarial; Drug development; Drug design;
Novel alleles of Plasmodium falciparum dhfr that confer resistance to chlorcycloguanil
Keywords: ضدعفونی کننده; Malaria; LapDap®; Drug resistance; Antifolate; Chlorproguanil;
Malignant Pleural Mesothelioma
Keywords: ضدعفونی کننده; Malignant pleural mesothelioma; Asbestos; SV40; Antifolate;