دانلود مقالات ISI درباره فعالیت ضد انعقادی + ترجمه فارسی

Synthesis and the interaction of 2-(1H-pyrazol-4-yl)-1H-imidazo[4,5-f][1,10]phenanthrolines with telomeric DNA as lung cancer inhibitors

Keywords: فعالیت ضد انعقادی; Phenanthroline; Lung adenocarcinoma; Antiproliferative activity; Telomeric G-quadruplex;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

p53 dependent apoptosis and cell cycle delay induced by heteroleptic complexes in human cervical cancer cells

Keywords: فعالیت ضد انعقادی; Anticancer; Antiproliferative activity; Apoptosis; Cell cycle; Cytotoxicity; Reactive oxygen species; FBS; fetal bovine serum; DCFH-DA; 2′7′-dichlorodihydrofluorescein diacetate; AO; acridine orange; EtBr; ethidium bromide; PI; Propidium Iodide; DL ce

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Novel 2-aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridines as potent DNA non-intercalative topoisomerase catalytic inhibitors

Keywords: فعالیت ضد انعقادی; Anticancer agents; 2-Aryl-4-(4′-hydroxyphenyl)-5H-indeno[1,2-b]pyridine; Antiproliferative activity; Docking study; Dual topoisomerase I and II inhibitors;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor

Keywords: فعالیت ضد انعقادی; 2,4-chloro- and hydroxy-substituted diphenyl benzofuro[3,2-b]pyridines; Dual topoisomerase I and II inhibition; Antiproliferative activity; Non-intercalative catalytic inhibiton; Anticancer agent;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a] pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules

Keywords: فعالیت ضد انعقادی; Hybrid molecules; Antiproliferative activity; ROS; Mitochondria; Cell cycle; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and evaluation of 4-substituted anthra[2,1-c][1,2,5]thiadiazole-6,11-dione derivatives as novel non-camptothecin topoisomerase I inhibitors

Keywords: فعالیت ضد انعقادی; Topoisomerase I inhibitors; Anthrathiadiazole; Antiproliferative activity; Structure-activity relationship;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of 9H-purins as potential tubulin polymerization inhibitors: Synthesis, biological evaluation and structure−activity relationships

Keywords: فعالیت ضد انعقادی; 9H-purins; Antiproliferative activity; Tubulin-polymerization inhibitors; Apoptosis; Cell cycle arrest;

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and antiproliferative activity of thiazolo[5,4-d]pyrimidine derivatives through the atom replacement strategy

Keywords: فعالیت ضد انعقادی; Thiazolo[5,4-d]pyrimidine; Antiproliferative activity; Apoptosis; Atom replacement;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and biological evaluation of cis-restricted triazole/tetrazole mimics of combretastatin-benzothiazole hybrids as tubulin polymerization inhibitors and apoptosis inducers

Keywords: فعالیت ضد انعقادی; Combretastatin A-4; Benzothiazole; Triazoles and tetrazoles; Antiproliferative activity; Tubulin polymerization; Colchicine competition assay; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and preliminary biological evaluation of new [1,2,3]triazolo[4,5-d]pyrimidine/thiourea hybrids as antiproliferative agents

Keywords: فعالیت ضد انعقادی; Thiourea; [1,2,3]triazolo[4,5-d]pyrimidine; Antiproliferative activity; Scaffold replacement; Ring cleavage;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of thiazolo[5,4-d]pyrimidine derivatives as potent antiproliferative agents through the drug repurposing strategy

Keywords: فعالیت ضد انعقادی; Thiazolo[5,4-d]pyrimidine; Antiproliferative activity; Apoptosis; Drug repurposing;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of novel naphthoquinone derivatives as inhibitors of the tumor cell specific M2 isoform of pyruvate kinase

Keywords: فعالیت ضد انعقادی; Pyruvate kinase M2; PKM2 inhibitor; Naphthoquinone derivatives; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, characterization, crystal structure and antiproliferative activity studies of Cu(II), Ni(II) and Co(II) complexes with 4-benzoyl-5-pyrazolones derived compounds

Keywords: فعالیت ضد انعقادی; Thiosemicarbazone; Copper(II); Nickel(II) and cobalt(II) complexes; Crystal structure; EPR studies; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Development of N-hydroxycinnamamide-based HDAC inhibitors with improved HDAC inhibitory activity and in vitro antitumor activity

Keywords: فعالیت ضد انعقادی; HDAC; Inhibitors; Antiproliferative activity; Selectivity;

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Triazolopyridinyl-acrylonitrile derivatives as antimicrotubule agents: Synthesis, in vitro and in silico characterization of antiproliferative activity, inhibition of tubulin polymerization and binding thermodynamics

Keywords: فعالیت ضد انعقادی; Triazolo[4,5-b/c]pyridin-acrylonitriles; Antiproliferative activity; Tubulin polymerization; Molecular modeling; Isothermal titration calorimetry; Fluorescence-based assays;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Antiproliferative activity of spinasterol isolated of Stegnosperma halimifolium (Benth, 1844)

Keywords: فعالیت ضد انعقادی; Stegnosperma halimifolium; Stegnospermaceae; Antiproliferative activity; Spinasterol;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, crystal structures and antitumor activity of two platinum(II) complexes with methyl hydrazinecarbodithioate derivatives of indolin-2-one

Keywords: فعالیت ضد انعقادی; Platinum(II) complex; Hydrazinecarbodithioate; Synthesis; Antiproliferative activity; Apoptosis; cDDP; cis-diamminedichloroplatinum(II); DAPI; 4′,6-diamidino-2-phenylindole; DMSO; dimethyl sulphoxide; EB; ethidium bromide; MTS; 3-(4,5-dimethylthiazol-2-

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Complex formation reactions of gallium(III) and iron(III/II) with l-proline-thiosemicarbazone hybrids: A comparative study

Keywords: فعالیت ضد انعقادی; Thiosemicarbazones; Gallium(III); Iron(III); Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Lipophilicity-antiproliferative activity relationship study leads to the preparation of a ruthenium(II) arene complex with considerable in vitro cytotoxicity against cancer cells and a lower in vivo toxicity in zebrafish embryos than clinically approved

Keywords: فعالیت ضد انعقادی; Ruthenium complexes; Antiproliferative activity; Lipophilicity; Cancer; In vivo toxicity; Zebrafish; Cis-platin; cis-diamminedichloroplatinum(II); NAMI-A; Imidazolium-trans-tetrachloro(dimethylsulfoxide) imidazole ruthenium(III); RAPTA; ([Ru(η6-arene)Cl

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Novel amidino substituted benzimidazole and benzothiazole benzo[b]thieno-2-carboxamides exert strong antiproliferative and DNA binding properties

Keywords: فعالیت ضد انعقادی; Amidines; Antiproliferative activity; Benzimidazoles; benzo[b]thieno-2-carboxamides; Benzothiazoles; DNA binding; Topoisomerase poisoning;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

Heteroleptic tris-chelate ruthenium(II) complexes of N,N-disubstituted-N′-acylthioureas: Synthesis, structural studies, cytotoxic activity and confocal microscopy studies

Keywords: فعالیت ضد انعقادی; Acylthiourea derivatives; Crystal structures; Ruthenium complexes; Antiproliferative activity; Confocal microscopy;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation

Keywords: فعالیت ضد انعقادی; Scutellarin; Antiproliferative activity; Selectivity; NO; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Structure elucidation, DNA binding specificity and antiproliferative proficiency of isolated compounds from Garcinia nervosa

Keywords: فعالیت ضد انعقادی; Garcinia nervosa; Isoflavone; X-ray analysis; DNA binding study; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis, antitumor activity and CDK1 inhibiton of new thiazole nortopsentin analogues

Keywords: فعالیت ضد انعقادی; Marine alkaloids; Nortopsentin analogues; Antiproliferative activity; Apoptosis; CDK1 inhibitors; Thiazolyl-1H-pyrrolo[2,3-b]pyridines;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Antiproliferative activity of amino substituted benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles explored by 2D and 3D cell culture system

Keywords: فعالیت ضد انعقادی; Antiproliferative activity; benzo[b]thieno[2,3-b]pyrido[1,2-a]benzimidazoles; 2D and 3D in vitro cytotoxicity assay; Lipophilicity; Physico-chemical properties;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Design and synthesis of new RAF kinase-inhibiting antiproliferative quinoline derivatives. Part 2: Diarylurea derivatives

Keywords: فعالیت ضد انعقادی; Antiproliferative activity; C-RAF kinase; Diarylurea; Molecular docking; Quinoline;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Structure-activity relationship studies of 1,7-diheteroarylhepta-1,4,6-trien-3-ones with two different terminal rings in prostate epithelial cell models

Keywords: فعالیت ضد انعقادی; 1,7-Diheteroarylhepta-1,4,6-trien-3-one; Antiproliferative activity; Prostate cancer; Structure-activity relationship; Cell apoptosis;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis, and biological evaluation of cyclic-indole derivatives as anti-tumor agents via the inhibition of tubulin polymerization

Keywords: فعالیت ضد انعقادی; Cyclic-indole derivatives; Antiproliferative activity; Tubulin polymerization inhibitor; Cell cycle arrest; Apoptosis; CA-4; Combretastain A-4; VDAs; vascular disrupting agents; HMTA; hexamethylenetetramine; HUVECs; human umbilical vein endothelial cells;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Design, facile synthesis and biological evaluations of novel pyrano[3,2-a]phenazine hybrid molecules as antitumor agents

Keywords: فعالیت ضد انعقادی; Pyrano[3,2-a]phenazine; Hybrid molecules; Antiproliferative activity; In vivo assay; Topoisomerase dual inhibition; Cell cycle arrest; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2017 سفارش ترجمه

Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines: Topoisomerase I and IIα dual inhibitors with DNA non-intercalative catalytic activity

Keywords: فعالیت ضد انعقادی; Antiproliferative agents; Dihydroxylated 2,6-diphenyl-4-chlorophenylpyridines; Dual inhibitors of topo I and topo IIα; Antiproliferative activity; DNA non-intercalative catalytic inhibitor;

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2017 سفارش ترجمه

The synthesis and biological evaluation of unsymmetrical 2,2-di(1H-indol-3-yl)-N-phenylacetamide derivatives

Keywords: فعالیت ضد انعقادی; 2,2-Di(1H-indol-3-yl)-N-phenylacetamide derivatives; Indole; Unsymmetrical; AlCl3; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Total NMR assignment of a new antiproliferative triterpene oligoglycoside from the sea cucumber Astichopus multifidus

Keywords: فعالیت ضد انعقادی; NMR; 1D-TOCSY; Triterpene oligoglycosides; Astichopus multifidus; Antiproliferative activity; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2016 سفارش ترجمه

Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors

Keywords: فعالیت ضد انعقادی; Epigenetic; Protein-protein interactions; Bromodomain; HDAC; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and biological evaluation of novel 3-alkylsulfanyl-4-amino-1,2,4-triazole derivatives

Keywords: فعالیت ضد انعقادی; 1,2,4-Triazole; Alkylsulfanyl; Synthesis; Antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Poly(ε-caprolactone)/bioactive glass composites enriched with polyphenols extracted from sage (Salvia officinalis L.)

Keywords: فعالیت ضد انعقادی; Biomaterials; Polymeric composites; Polyphenols; Bioactivity; Antioxidant activity; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and antiproliferative activity of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing the 2-oxo-4-chloro-1,2-dihydroquinoline-3-carboxamide moiety

Keywords: فعالیت ضد انعقادی; Synthesis; Quinoline derivatives; 2-Oxo-4-chloro-1,2-dihydroquinoline; c-Met; Antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Discovery of novel pyrrolo[2,3-b]pyridine derivatives bearing 1,2,3-triazole moiety as c-Met kinase inhibitors

Keywords: فعالیت ضد انعقادی; Synthesis; Pyrrolo[2,3-b]pyridine derivatives; 1,2,3-Triazole; c-Met; Antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Design, synthesis and antiproliferative activity studies of novel dithiocarbamate–chalcone derivates

Keywords: فعالیت ضد انعقادی; Chalcone; Dithiocarbamate; Antiproliferative activity; Apoptosis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and antiproliferative activity of peracetylated 2-amino-1,2-dideoxy-1-nitro-d-glycero-l-manno and d-glycero-d-talo heptitols

Keywords: فعالیت ضد انعقادی; Stereoselectivity; Nitroalkenes; Amines; Michael reactions; Carbohydrates; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

New cytotoxic callipeltins from the Solomon Island marine sponge Asteropus sp.

Keywords: فعالیت ضد انعقادی; Callipeltin; Asteropus; NMR; LCMS; Derivatisation; Antiproliferative activity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Novel 5-substituted-2-anilinoquinolines with 3-(morpholino or 4-methylpiperazin-1-yl)propoxy moiety as broad spectrum antiproliferative agents: Synthesis, cell based assays and kinase screening

Keywords: فعالیت ضد انعقادی; 2-Anilinoquinolines; Antiproliferative activity; 3-(Morpholino)propoxy; 3-(4-Methylpiperazin-1-yl)propoxy; TrkA kinase

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Effects of Calophyllum inophyllum fruit extract on the proliferation and morphological characteristics of human breast cancer cells MCF-7

Keywords: فعالیت ضد انعقادی; Antiproliferative activity; Human breast cancer; CyQuant assays; Giemsa staining

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis of novel C2-symmetric testosterone dimers and evaluation of antiproliferative activity on androgen-dependent and -independent prostate cancer cell lines

Keywords: فعالیت ضد انعقادی; T, testosterone; T-T, testosterone dimers; AR, androgen receptorTestosterone; Testosterone dimers; Prostate cancer; Antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Palladium-catalyzed external-oxidant-free coupling reactions between isoquinoline/quinoline N-oxides with olefins

Keywords: فعالیت ضد انعقادی; 1-Alkenylisoquinolines; Coupling reaction; Antiproliferative activity; MTT assay;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, antitumor evaluation and 3D-QSAR studies of [1,2,4]triazolo[4,3-b][1,2,4,5]tetrazine derivatives

Keywords: فعالیت ضد انعقادی; SSHHAQKQMJBRPW-UHFFFAOYSA-N; Triazole; Tetrazine; X-ray diffraction; Antiproliferative activity; 3D-QSAR; CoMFA; CoMSIA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Preselection of A- and B- modified d-homo lactone and d-seco androstane derivatives as potent compounds with antiproliferative activity against breast and prostate cancer cells - QSAR approach and molecular docking analysis

Keywords: فعالیت ضد انعقادی; Antiproliferative activity; Artificial neural networks; Chemometrics; d-homo lactone and d-seco androstane derivatives; Molecular docking; QSAR;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

Keywords: فعالیت ضد انعقادی; COX-2 inhibitors; 1,5-diarylpyrrole derivatives; Anti-inflammatory agents; Antinociceptive agents; Antiproliferative activity; Molecular modelling

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

The in vitro antitumor activity of arene-ruthenium(II) curcuminoid complexes improves when decreasing curcumin polarity

Keywords: فعالیت ضد انعقادی; Ruthenium(II); Modified curcumin; Liposolubility; Antiproliferative activity;  < Beta >-diketone; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Stereocontrolled synthesis of the four 16-hydroxymethyl-19-nortestosterone isomers and their antiproliferative activities

Keywords: فعالیت ضد انعقادی; 19-Nortestosterone; 17α-19-Nortestosterone; Stereocontrolled synthesis; Birch reduction; Antiproliferative activity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, characterization, crystal structure, redox-reactivity and antiproliferative activity studies of Cu(II) and Pd(II) complexes with F, CF3 bearing 3,5-di-tert-butylsalicylaldimines

Keywords: فعالیت ضد انعقادی; F,CF3Ph-salicylaldimines; X-ray; CuII-phenoxyl; Antiproliferative activity; Redox reactivity

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه