Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, Antigen-presenting cell; IL, Interleukin; Lfc, Lactoferricin; LPS, Lipopolysaccharide; PAMP, Pathogen-associated microbial pattern; PMN, Polymorphonuclear neutrophil; Tf, Transferrin; TLR, Toll-like receptor
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Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; ATP, adenosine triphosphate; BRCA2, breast cancer susceptibility gene 2; CR, complete response; CTLA-4, cytotoxic T lymphocyte-associated antigen 4; CSF1R, colony-stimulating factor 1 receptor; CTL, cytotoxic T lymphocyte; DC
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ab, antibody; ADCC, antibody-dependent cell cytotoxicity; APC, antigen-presenting cell; CTA, cancer/testis antigen; CTL, cytotoxic T lymphocyte; DC, dendritic cell; GITR, glucocorticoid-induced tumor necrosis factor receptor; GM-CSF, granulocyte-macrophag
Keywords: APC، سلول ارائه دهنده آنتی ژن; AdHu5, human type 5 adenovirus; ALT, airway luminal T cell; APC, antigen-presenting cell; BCG, Bacille Calmette-Guérin; IFN, interferon; LIT, lung interstitial T cell; RM, respiratory mucosal; Th1, T helper cell type 1; WHO, World Health Organizati
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; CT, cholera toxin; CDR, complementarity-determining region; CB, cord blood; DC, dendritic cell; DN, double negative; DP, double positive; ETEC, enterotoxigenic Escherichia coli; GIT, gastrointestinal tract; LT, heat-labile en
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BLT, bone marrow/liver/thymus; BRG, C.129(cg)-Rag2tm1Fwa9Il2rgtm1Cgn; CMV, cytomegalovirus; CRISPR, Clustered Regularly Interspaced Short Palindromic Repeats CRISPR/Cas9; EBV, Epstein–Barr Virus; ESC, embryonic stem cell; FDC
The immunomodulatory effect of laquinimod in CNS autoimmunity is mediated by the aryl hydrocarbon receptor
Keywords: APC، سلول ارائه دهنده آنتی ژن; AhR, aryl hydrocarbon receptor; APC, antigen-presenting cell; BDNF, brain-derived neurotrophic factor; CNS, central nervous system; DC, dendritic cell; EAE, experimental autoimmune encephalomyelitis; KO, knockout; MOG, myelin oligodendrocyte glycoprotein;
Efficient induction of cross-presentating human B cell by transduction with human adenovirus type 7 vector
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; ARD, acute respiratory disease; APM, antigen-processing machinery; CEA, carcinoembryonic antigen; CPE, cytopathic effect; Ct, threshold cycle; CTL, cytotoxic T lymphocytes; DC, dendritic cell; DSG-2, desmoglein 2; ELISA, enzy
DNA vaccines to attack cancer: Strategies for improving immunogenicity and efficacy
Keywords: APC، سلول ارائه دهنده آنتی ژن; AIM, absent in melanoma; APC, antigen-presenting cell; CEA, carcinoembryonic antigen; CCL, chemokine (C-C motif) ligand; CCR, chemokine (C-C motif) receptor; CXCL, chemokine (C-X-C motif) ligand, CXCL; CD, cluster of differentiation; CMV, cytomegalovirus;
Human immunomodulation and initial HIV spread
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ab, antibody; AHI, acute HIV infection; AIDS, acquired immunodeficiency syndrome; APC, antigen-presenting cell; CTE, critical therapy efficiency; DC, dendritic cell; FDC, follicular dendritic cell; Fe, iron; GLN, genital lymph node; HAART, highly active a
Preventing T cell rejection of pig xenografts
Keywords: APC، سلول ارائه دهنده آنتی ژن; Xenotransplantation; Cellular rejection; T cell-mediated rejection; Pig xenografts; Nonhuman primate; Renal transplantAMR, antibody-mediated rejection; APC, antigen-presenting cell; ATG, antithymocyte globulin; BM, bone marrow; CTLA-4, cytotoxic T-lymphoc
HLA-G and susceptibility to develop celiac disease
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; AU, Absorbance Units; CD, celiac disease; CD4+, CD4 positive; C.I., confidence interval; CTL, cytotoxic T lymphocyte; EMA, anti-endomysial antibodies; F, female; HC, healthy controls; HLA-G, Human Leukocyte Antigen-G; IFN-γ,
eIF2α phosphorylation as a biomarker of immunogenic cell death
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; ATF, activating transcription factor; CALR, calreticulin; CTL, cytotoxic T lymphocyte; DAMP, damage-associated molecular pattern; DC, dendritic cell; eIF2α, eukaryotic translation initiation factor 2α; EIF2AK, eIF2α kinase; E
Divergent effects of type-I interferons on regulatory T cells
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; cAMP, cyclic adenosine monophosphate; CHC, chronic hepatitis C; IFN, interferon; IFNAR, interferon α/β receptor; IL, interleukin; IRF, interferon regulatory factor; IRFE, interferon regulatory factor-binding element; ISG, int
CD8 T cells and dendritic cells: key players in the attenuated maternal immune response to influenza infection
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BDCA, blood-derived cellular antigen; CD, cellular-derived antigen; DC, dendritic cell; dsRNA, double-stranded RNA; H1N1pdm09, 2009 pandemic swine flu; HRVs, human rhinoviruses; IFN, interferon; ISGs, interferon-stimulated ge
Influence of trehalose 6,6′-diester (TDX) chain length on the physicochemical and immunopotentiating properties of DDA/TDX liposomes
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; DDA, dimethyldioctadecylammonium; DLS, dynamic light scattering; DSC, differential scanning calorimetry; IFN-γ, interferon γ; IL-5, interleukin 5; IL-17a, interleukin 17a; PAMP, pathogen-associated molecular pattern; PDI, pol
IFN-β and multiple sclerosis: Cross-talking of immune cells and integration of immunoregulatory networks
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BAFF, B-cell-activating factor of the TNF family; BBB, blood–brain barrier; CIS, clinically isolated syndrome; CNS, central nervous system; CSF, cerebrospinal fluid; CXCL, CXC-motif ligand; DC, dendritic cell; EAE, experiment
Salmonella impairs CD8 T cell response through PD-1: PD-L axis
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; CFU, colony-forming unit; FACS, fluorescence-activated cell sorter; FITC, fluorescein isothiocyanate; IFN, interferon; IL, interleukin; i.p., intraperitoneal; i.v., intravenous; mAb, monoclonal Ab; MHC, major histocompatibili
Immune-mediated adverse events of anticytotoxic T lymphocyte–associated antigen 4 antibody therapy in metastatic melanoma
Keywords: APC، سلول ارائه دهنده آنتی ژن; ADCC, antibody-dependent cell-mediated cytotoxicity; APC, antigen-presenting cell; BRAF, V-Raf Murine Sarcoma Viral Oncogene Homolog B; CIDP, chronic inflammatory demyelinating polyneuropathy; CT, cancer/testis; CTLA-4, cytotoxic T lymphocyte-associated a
Dysregulated Intrahepatic CD4+ T-Cell Activation Drives Liver Inflammation in Ileitis-Prone SAMP1/YitFc Mice
Keywords: APC، سلول ارائه دهنده آنتی ژن; Hepatic CD4+ T Cells; IBD-Associated Liver Inflammation; Liver Sinusoidal Endothelial Cells; Regulatory T Cells; SAMP1/YitFc MiceAIH, autoimmune hepatitis; AKR, AKR/J; ALP, alkaline phosphatase; ALT, alanine aminotransferase; APC, antigen-presenting cell;
Human monocytes produce interferon-gamma upon stimulation with LPS
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; LPS, lipopolysaccharide; Mph, macrophage; MS, multiple sclerosis; NK, natural killer cell; Tx recipient, renal transplant recipientMonocytes; IFN-γ; LPS; Macrophage; Transplantation
Bacterial ligand stimulates TLR2-dependent chemokines of colon cell
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; LPS, lipopolysaccharide; MYD88, myeloid differentiation factor 88; SARM, sterile alpha and TIR motif containing 1; TICAM-1, toll-like receptor adaptor molecule 1; TICAM-2, toll-like receptor adaptor molecule 2; TIRAP, TIR dom
C-type lectin receptor SIGNR1 expressed on peritoneal phagocytic cells with an immature dendritic cell-like phenotype is involved in uptake of oligomannose-coated liposomes and subsequent cell maturation
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BNCP, biantennary N-linked core pentasaccharide; CLR, C-type lectin receptor; DC, dendritic cell; DPPE, dipalmitoylphosphatidylethanolamine; LNFP, lacto-N-fucopentaose; LNT, lacto-N-tetraose; Man3, mannotriose; Man3-DPPE, neo
Coadministration of antigen-conjugated and free CpG: Effects of in vitro and in vivo interactions in a murine model
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; ASC, antibody-secreting cell; BMDC, bone marrow-derived dendritic cell; CpG, cytosine guanine dinucleotide-containing unmethylated DNA motif (in this study: ODN 1668); CTRL, control oligonucleotide (in this study: ODN 1720);
NFAT1 transcription factor in dendritic cells is required to modulate T helper cell differentiation
Keywords: APC، سلول ارائه دهنده آنتی ژن; Cytokines; Dendritic cells; Lymphocyte differentiation; NFAT; Th1/Th2 cellsAb, antibody; APC, antigen-presenting cell; CFA, Complete Freund's Adjuvant; CsA, cyclosporin A; DC, dendritic cell; Iono, ionomycin; OVA, ovalbumin; RPA, RNase protection assay; T
Comparison of the carbohydrate preference of SIGNR1 as a phagocytic receptor with the preference as an adhesion molecule
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BNCP, biantennary N-linked core pentasaccharide; CLR, C-type lectin receptor; DC, dendritic cell; DPPE, dipalmitoylphosphatidylethanolamine; LNDFH, lacto-N-difucophexaose; LNFP, lacto-N-fucopentaose; LNT, lacto-N-tetraose; Ma
Regulation of T lymphocyte apoptotic markers is associated to cell activation during the acute phase of dengue
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ag, antigen; ANOVA, analysis of variance; APC, antigen-presenting cell; APC-Cy7, allophycocyanin conjugated cyanine dye; BSA, bovine serum albumin; CD, cluster of differenciation; FasL, Fas ligand; CD95/Fas, Fas death receptor; Cy, cycrome; DENV, dengue v
Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BBB, blood brain barrier; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; CNS, central nervous system; DC, dendritic cell; EAE, experimental autoimmune encephalomyelitis; FACS, fluorescence activated cell sorter; LP
Human immunity in vitro — Solving immunogenicity and more
Keywords: APC، سلول ارائه دهنده آنتی ژن; ADDC, antibody-dependent cell-mediated cytotoxicity; ALN, artificial lymph node; AOP, adverse outcome pathway; APC, antigen-presenting cell; CMV, cytomegalovirus; DC, dendritic cell; DNCB, dinitrochlorobenzene; ECM, extracellular matrix; ELISPOT, enzyme-l
Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: A mouse model study
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; ATP, adenosine-5′-triphosphate; BCG, bacille Calmette-Guerin; CFU, colony-forming unit; FBS, fetal bovine serum; HIV, human immunodeficiency virus; MDR, multidrug-resistant; OADC, oleic acid, albumin, dextrose, catalase; PBS,
The dominant roles of ICAM-1-encoding gene in DNA vaccination against Japanese encephalitis virus are the activation of dendritic cells and enhancement of cellular immunity
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; CFSE, 5-(and 6-)carboxyfluorescein diacetate succinimidyl ester; CTL, cytotoxic T lymphocyte; DC, dendritic cell; FBS, fetal bovine serum; FCS, fetal calf serum; FITC, fluorescein isothiocyanate; ICAM, intercellular adhesion
IGRAs – The gateway to T cell based TB diagnosis
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BCG, Bacille Calmette-Guérin; BCIP/NBT, 5-bromo-4-chloro-3-indolyl phosphate/nitro blue tetrazolium; CDC, Centers for Disease Control and Prevention; CFP-10, culture filtrate protein 10 kDa; CD, cluster of differentiation; CI
Increased numbers and suppressive activity of regulatory CD25+CD4+ T lymphocytes in the absence of CD4 engagement by MHC class II molecules
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ab, antibody; AICD, activation-induced cell death; APC, antigen-presenting cell; FITC, fluorescein isothiothyanate; IFN, interferon; IL-2, interleukin-2; MHC, major histocompatibility complex; Ova323, ovalbumin peptide 323-339; R-PE, phycoerythrin; SEA, S
Histone deacetylase inhibition by Japanese encephalitis virus in monocyte/macrophages: A novel viral immune evasion strategy
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; CCL-2, chemokine (C-C motif) ligand 2; EGCG, epigallocatechin gallate; HDAC, histone deacetylase; IDO, indoleamine 2,3-dioxygenase; IFN, interferon; IL-6, interleukin 6; IRF3, Interferon regulatory factor 3; JEV, Japanese enc
Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ag, antigen; APC, antigen-presenting cell; CSSS, cyanoacrylate skin surface stripping; CT, cholera toxin; DC, dendritic cell; dDC, dermal dendritic cell; DT, diphtheria toxoid; ELISA, enzyme-linked immunosorbent assay; EpCAM, epithelial cell adhesion mole
Mitochondrial dysfunction and the inflammatory response
Keywords: APC، سلول ارائه دهنده آنتی ژن; 4-HNE, 4-hydroxy-2-nonenal; ∆ψm, mitochondrial membrane potential; AD, Alzheimer's disease; AP-1, activator protein-1; APC, antigen-presenting cell; ASC, apoptosis-associated speck-like protein containing a caspase recruitment domain; ATP, adenosine triph
Basophils and allergic inflammation
Keywords: APC، سلول ارائه دهنده آنتی ژن; Basophil; allergy; TH2 cytokine; thymic stromal lymphopoietin; allergic rhinitis; asthma; atopic dermatitis; urticaria; food allergy; eosinophilic esophagitis; IgEAD, Atopic dermatitis; APC, Antigen-presenting cell; AR, Allergic rhinitis; BaP, Basophil pr
Mechanistic basis of immunotherapies for type 1 diabetes mellitus
Keywords: APC، سلول ارائه دهنده آنتی ژن; Aire, autoimmune regulator; APC, antigen-presenting cell; ATG, antithymocyte globulin; CTLA-4, cytotoxic T-lymphocyte antigen 4; DCs, dendritic cells; FcR, Fc receptor; GAD65, glutamate decarboxylase 65; GWAS, genome-wide association studies; HLA, human l
Viral infection of the lung: Host response and sequelae
Keywords: APC، سلول ارائه دهنده آنتی ژن; Viral sensor molecules; innate immunity; adaptive immunity; T-cell immunity; B-cell immunity; viral clearance; tissue repair; stem cellsAIM2, Absent in melanoma 2; APC, Antigen-presenting cell; ASC, Apoptosis-associated speck-like protein containing CARD;
Particulate formulations for the delivery of poly(I:C) as vaccine adjuvant
Keywords: APC، سلول ارائه دهنده آنتی ژن; AIM 2, absent-in-melanoma 2; APC, antigen-presenting cell; BMDC, bone marrow-derived DC; CLR, C-type lectin receptor; CTAB, cetytrimethylammonium bromide; CTL, cytotoxic T lymphocyte; DAI, DNA-dependent activator of IFN-regulatory factor; DAMP, danger-ass
A myriad of functions and complex regulation of the CCR7/CCL19/CCL21 chemokine axis in the adaptive immune system
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; BCR, B cell receptor; CCL, CC chemokine ligand; CCR, CC chemokine receptor; TCM, central memory T cell; CNS, central nervous system; CMJ, cortico-medullary junction; CXCL, CXC chemokine ligand; CXCR, CXC chemokine receptor; D
Evaluating risks of insertional mutagenesis by DNA transposons in gene therapy
Keywords: APC، سلول ارائه دهنده آنتی ژن; AIDS, acquired immunodeficiency disease syndrome; APC, antigen-presenting cell; CAG, cytomegalovirus beta-actin hybrid promoter; CAR, chimeric antigen receptor; CLL, chronic lymphocytic leukemia; CMV, cytomegalovirus; CRC, clinical research center; DGF, d
New Wisdom to Defy an Old Enemy: Summary from a scientific symposium at the 4th Influenza Vaccines for the World (IVW) 2012 Congress, 11 October, Valencia, Spain
Keywords: APC، سلول ارائه دهنده آنتی ژن; AlPO4, aluminum phosphate; APC, antigen-presenting cell; AUC, area under the curve; BPL, Beta-Propiolactone; CI, confidence interval; FDA, US Food and Drug Administration; HAI, hemagglutination inhibition; hIVIg, hyperimmune intravenous immunoglobulin; HP
Transcutaneous immunization using a dissolving microneedle array protects against tetanus, diphtheria, malaria, and influenza
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ag, antigen; APC, antigen-presenting cell; BSA, bovine serum albumin; CT, cholera toxin; DT, diphtheria toxoid; HA, hemagglutinin; HI, hemagglutination inhibition; IDI, intradermal immunization; IMI, intramuscular immunization; MH, MicroHyala; PBS, phosph
Ipilimumab (Yervoy) and the TGN1412 catastrophe
Keywords: APC، سلول ارائه دهنده آنتی ژن; APC, antigen-presenting cell; CTLA-4, cytotoxic T lymphocyte-associated antigen-4; gp100, glycoprotein 100; irAEs, immune-related adverse events; mAbs, monoclonal antibodies; MHC, major histocompatibility complex; TCR, T cell receptor; Treg, regulatory T
In vivo two-photon imaging of T cell motility in joint-draining lymph nodes in a mouse model of rheumatoid arthritis
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ag, antigen; APC, antigen-presenting cell; Apc, allophycocyanin; BM, bone marrow; D, displacement; 2D, two-dimensional; DC, dendritic cell; DDA, dimethyldioctadecyl-ammonium bromide; FBS, fetal bovine serum; GM-CSF, granulocyte-macrophage colony stimulati
A low-invasive and effective transcutaneous immunization system using a novel dissolving microneedle array for soluble and particulate antigens
Keywords: APC، سلول ارائه دهنده آنتی ژن; Ad, adenovirus vector; Ag, antigen; APC, antigen-presenting cell; DC, dendritic cell; dDC, dermal dendritic cell; ELISA, enzyme-linked immunosorbent assay; ELISPT, enzyme-linked immunospot; FITC, fluorescein isothiocyanate; HEK, human embryonic kidney; ID
Evolution of oncolytic adenovirus for cancer treatment
Keywords: APC، سلول ارائه دهنده آنتی ژن; ABP, arginine-grafted bioreducible polymer; Ad, adenovirus; APC, antigen-presenting cell; CD or poly(CBA-DAH), poly(cystaminebisacrylamide-diaminohexane); CAR, coxsackievirus and adenovirus receptors; DC, dendritic cell; E1A- and E1B-double mutant oncolyt
Trypanosoma cruzi paraflagellar rod proteins 2 and 3 contain immunodominant CD8+ T-cell epitopes that are recognized by cytotoxic T cells from Chagas disease patients
Keywords: APC، سلول ارائه دهنده آنتی ژن; PFR, paraflagellar rod protein; HSP, heat shock protein; KMP, kinetoplastid membrane protein; PBMC, peripheral blood mononuclear cells; TAP, transporters associated with antigen-processing; APC, antigen-presenting cell; SFC, spot forming cell; CTL, cytoto
CCR9+ Macrophages Are Required for Acute Liver Inflammation in Mouse Models of Hepatitis
Keywords: APC، سلول ارائه دهنده آنتی ژن; Immune Regulation; Hepatic Disease; Chemokine Receptor; T-Cell ActivationAH, acute hepatitis; APC, antigen-presenting cell; CH, chronic hepatitis; cDC, conventional dendritic cell; con A, concanavalin A; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; IF