کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2403156 | 1102886 | 2013 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery Frontiers of transcutaneous vaccination systems: Novel technologies and devices for vaccine delivery](/preview/png/2403156.png)
Transcutaneous immunization (TCI) systems that use the skin's immune function are promising needle-free, easy-to-use, and low-invasive vaccination alternative to conventional, injectable vaccination methods. To develop effective TCI systems, it is essential to establish fundamental techniques and technologies that deliver antigenic proteins to antigen-presenting cells in the epidermis and dermis while overcoming the barrier function of the stratum corneum. In this review, we provide an outline of recent trends in the development of techniques for the delivery of antigenic proteins and of the technologies used to enhance TCI systems. We also introduce basic and clinical research involving our TCI systems that incorporate several original devices.
Journal: Vaccine - Volume 31, Issue 19, 1 May 2013, Pages 2403–2415