Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; FC; free cholesterol; VLDL; very low density lipoprotein; LDL; low density lipoprotein; mTOR; mechanistic target of rapamycin signaling; AMPK; AMP-activated protein kinase; TG; t
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Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ABC; ATP-binding cassette; ASBT; apical sodium-dependent bile acid transporter; Bamet-UD2; cisplatin-ursodeoxycholic acid derivative; CCA; cholangiocarcinoma; DHMEQ; dehydroxymethyl epoxyquinomicin; EGFR; epidermal growth factor receptor; 5-FU; 5-fluorour
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ABC; transporter; ATP; binding cassette transporter; AR; androgen receptor; ASBT; apical sodium-dependent bile acid transporter; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BT; Bblood-testis barrier; CS; cholesterol sulfate; DHEA; de
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; BMI; body mass index; CA; cholic acid; CA-D4; cholic acidâ2,2,4,4âD4; CARB; Carbohydrate and Related Biomarkers; CDCA; chenodeoxycholic acid; CRP; C-reactive protein; CV; coefficient of variation; D
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; ASDs; amorphous solid dispersions; BACS; bile acid-CoA synthase; BAT; bile acid-amino acid transferase; BCS; biopharmaceutics classification system; BSH; bile salt hydrolase; C4; 7α-hydroxy-4-cholesten
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; GC; glucocorticoid; BA; bile acid; GR; glucocorticoid receptor; FXR; farnesoid X receptor; SHP; short heterodimer partner; Asbt; Apical sodium-dependent bile acid transporter; CA; cholic acid; DCA; deoxycholic acid; α-MCA; α-muricholic acid; β-MCA; β-
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT, apical sodium-dependent bile acid transporter (SLC10A2); PEPT1, peptide transporter 1 (SLC15A1); SLC, solute carrierTransporter; Model; Michaelis–Menten; Apical sodium-dependent bile acid transporter
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ABC; ATP-binding cassette; AE2 (SLC4A2); anion exchanger 2; ALT; alanine aminotransferase; AMPK; AMP-activated protein kinase; ALP; alkaline phosphatase; ASBT (SLC10A2); apical sodium-dependent bile acid transporter; ASCOM; activating signal cointegrator-
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; AL; ad libitum; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; BAL; bile acid-CoA ligase; BAT; bile acid-CoA: amino acid N-acyltransferase; Bsep; bile salt export pump; CA; cholic acid; CDCA; chenodeoxycholic acid; CR; calorie restric
Intestinal Farnesoid X Receptor Activation by Pharmacologic Inhibition of the Organic Solute Transporter α-β
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Fluorescence Resonance Energy Transfer (FRET); FXR; OSTα-OSTβ; Bile Acids; ASBT; apical sodium-dependent bile acid transporter; BAS; bile acid sensor; FACS; fluorescence-activated cell sorting; FDA; Food and Drug Administration; FGF15/19; fibroblast gro
ApoE is a major determinant of hepatic bile acid homeostasis in mice
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ApoE; apolipoprotein E; BA; bile acid; HCHF; high-cholesterol/high-fat liver; Lrh; receptor homolog-1; Srebp1; sterol regulatory element-binding protein; Shp; small heterodimer partner; MCA; muricholic acid; CDCA; chenodeoxycholic acid; MRM; multiple reac
Human and rat precision-cut intestinal slices as ex vivo models to study bile acid uptake by the apical sodium-dependent bile acid transporter
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; DMSO; dimethyl sulfoxide; NTCP; Na+-taurocholate cotransporting polypeptide; OATP; organic anion transporting polypeptide; PBS; phosphate buffered saline; PCIS; precision-cut intestinal slices; PPPD; pa
Activation of PPARα decreases bile acids in livers of female mice while maintaining bile flow and biliary bile acid excretion
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Biliary excretion; PPARα; Bile acids; Gender difference; 1oBAs; Primary bile acids; 2oBAs; secondary bile acids; 12-OH; 12-hydroxylated bile acid; Asbt; apical sodium-dependent bile acid transporter; BA; bile acid; Baat; bile acid CoA:amino acid N-acyltr
Transhepatic bile acid kinetics in pigs and humans
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Bile acids; TGR5; Porcine; Postprandial; Portal concentrations; BAs; bile acids; ASBT; apical sodium-dependent bile acid transporter; OST; organic solute transporter; NTCP; taurocholate cotransporting polypeptide; OATP; organic anion transporting polypept
Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo
Natural products as modulators of the nuclear receptors and metabolic sensors LXR, FXR and RXR
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Natural products; Nuclear receptors; Liver X receptor; Farnesoid X receptor; Retinoid X receptor; Metabolic syndrome; Precision medicine; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid (obeticholic acid); AA; arachidonic acid; ABC; ATP-binding cassette transpor
An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT)
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; BAs; bile acids; PEPT1; peptide transporter 1; OCT1; organic cation transporter 1; OST alpha/beta; organic solute transporter alpha/beta; NTCP; Na+/taurocholate-cotransporting polypeptide; DDIs; drug-
Restoration of enterohepatic bile acid pathways in pregnant mice following short term activation of Fxr by GW4064
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Asbt; apical sodium-dependent bile acid transporter; Baat; bile acid CoA:amino acid N-acetyltransferase; Bal; bile acid CoA ligase; Bsep; bile salt export pump; Cyp; cytochrome P450; Fgf; fibroblast growth factor; Fxr; farnesoid X receptor; I-babp; ileal
HDL functionality in reverse cholesterol transport - Challenges in translating data emerging from mouse models to human disease
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ABC; ATP-binding cassette transporter; Apo; apolipoprotein; apobec1; apoB mRNA editing enzyme; ASBT; apical sodium-dependent bile acid transporter; BA; bile acids; BAT; bile acid CoA:amino acid N-acyltransferase; BSEP; bile salt export pump; CEC; choleste
Research ArticleGut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; BA; bile acid; Asbt; apical sodium-dependent bile acid transporter; KO; knock-out; iKO; intestinal-specific knock-out; WT; wildtype; CA; cholic acid; CDCA; chenodeoxycholic acid; MCA; muricholic acid; UDCA; urodeoxycholic acid; Gut microbiota; Intestinal
Research ArticleMouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; BA; bile acid(s); Asbt; apical sodium-dependent bile acid transporter; Ost; organic solute transporter; FXR; farnesoid X receptor; FGF15; fibroblast growth factor 15; Cyp7a1; cholesterol 7α-hydroxylase; FGFR4; fibroblast growth factor receptor 4; CA; cho
Research ArticleEffect of ursodeoxycholic acid on bile acid profiles and intestinal detoxification machinery in primary biliary cirrhosis and health
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; UDCA; ursodeoxycholic acid; PBC; primary biliary cirrhosis; ASBT; apical sodium-dependent bile acid transporter; FXR; farnesoid X receptor; PXR; pregnane X receptor; VDR; vitamin D receptor; CA; cholic acid; CDCA; chenodeoxycholic acid; DCA; deoxycholic a
Synthesis and In Vitro Evaluation of Gabapentin Prodrugs that Target the Human Apical Sodium-Dependent Bile Acid Transporter (hASBT)
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; transporters; prodrugs; gabapentin; apical sodium-dependent bile acid transporter; bile acid; active transport; bioavailability; permeability; stability;
Getting the mOST from OST: Role of organic solute transporter, OSTα-OSTβ, in bile acid and steroid metabolism
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ABC; ATP-binding cassette; ASBT; apical sodium-dependent bile acid transporter; DHEA; dehydroepiandrosterone; DHEAS; dehydroepiandrosterone-3-sulfate; ER; endoplasmic reticulum; Endo H; endoglycosidase H; FGF; fibroblast growth factor; FGFR; fibroblast gr
A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; BAM; bile acid malabsorption; C4; 7α-hydroxy-4-cholesten-3-one; CYP7A1; cholesterol 7α hydroxylase; ELISA; enzyme-linked immunosorbent assay; FGFR4; fibroblast growth receptor 4; FGF15;
Altered bile composition after liver transplantation is associated with the development of nonanastomotic biliary strictures
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ASBT; apical sodium-dependent bile acid transporter; AUC; area under the curve; BS; bile salts; BSEP; bile salt export pump; CH; cholesterol; FI; fold induction; γ
GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; GATA4; Friend of GATA; FOG; Intestinal differentiation; Apical sodium-dependent bile acid transporter; ASBT
Novel Model of Antigen-Specific Induction of Bile Duct Injury
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; CFSE; carboxyfluorescein diacetate succinimidyl ester; CTL; cytotoxic T lymphocytes; MNC; mononuclear cells; mOVA; membrane-bound ovalbumin; OVA; ovalbumin; PCR; polymerase chain reaction; PMA; phorbol
Novel non-systemic inhibitor of ileal apical Na+-dependent bile acid transporter reduces serum cholesterol levels in hamsters and monkeys
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; Apical sodium-dependent bile acid transporter; Enterohepatic circulation; Hypocholesterolemic agent; Monkey; Hamster; Cholesterol
Bile Acids Induce Ileal Damage During Experimental Necrotizing Enterocolitis
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; BA; bile acid; Chol; cholestyramine; DF; dam fed; DOC; deoxycholic acid; EGF; epidermal growth factor; FXR; farnesoid X receptor; IBABP; ileal bile acid binding protein; NEC; necrotizing enterocolitis;
The gene encoding the human ileal bile acid-binding protein (I-BABP) is regulated by peroxisome proliferator-activated receptors
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; ASBT; apical sodium-dependent bile acid transporter; I-BABP; ileal bile acid-binding protein; CYP7A1; cholesterol 7α-hydroxylase; CYP27A1; sterol 27-hydroxylase; CYP8B1; sterol 12α-hydroxylase; PPAR; peroxisome proliferator-activated receptors; RXR; ret
Molecular mechanisms of cholesterol absorption and transport in the intestine
Keywords: اپوکسی سدیم وابسته به پروتئین اسید صفرا; PTL; pancreatic triglyceride lipase; CEL; carboxyl ester lipase; PTLRP; pancreatic triglyceride lipase related protein; ASBT; apical sodium-dependent bile acid transporter; ABC; ATP binding cassette; SR-BI; scavenger receptor class B type I; NPC; Niemann-